Recombinant Human Synapsin III protein is a Human Full Length protein, in the 1 to 580 aa range, expressed in Wheat germ and suitable for ELISA, WB.
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Key facts
- Expression system
- Wheat germ
- Tags
- GST tag N-Terminus
- Applications
- ELISA, WB
- Biologically active
- No
Amino acid sequence
M N F L R R R L S D S S F M A N L P N G Y M T D L Q R P D S S T S S P A S P A M E R R H P Q P L A A S F S S P G S S L F S S L S S A M K Q A P Q A T S G L M E P P G P S T P I V Q R P R I L L V I D D A H T D W S K Y F H G K K V N G E I E I R V E Q A E F S E L N L A A Y V T G G C M V D M Q V V R N G T K V V S R S F K P D F I L V R Q H A Y S M A L G E D Y R S L V I G L Q Y G G L P A V N S L Y S V Y N F C S K P W V F S Q L I K I F H S L G P E K F P L V E Q T F F P N H K P M V T A P H F P V V V K L G H A H A G M G K I K V E N Q L D F Q D I T S V V A M A K T Y A T T E A F I D S K Y D I R I Q K I G S N Y K A Y M R T S I S G N W K A N T G S A M L E Q V A M T E R Y R L W V D S C S E M F G G L D I C A V K A V H S K D G R D Y I I E V M D S S M P L I G E H V E E D R Q L M A D L V V S K M S Q L P M P G G T A P S P L R P W A P Q I K S A K S P G Q A Q L G P Q L G Q P Q P R P P P Q G G P R Q A Q S P Q P Q R S G S P S Q Q R L S P Q G Q Q P L S P Q S G S P Q Q Q R S P G S P Q L S R A S S G S S P N Q A S K P G A T L A S Q P R P P V Q G R S T S Q Q G E E S K K P A P P H P H L N K S Q S L T N S L S T S D T S Q R G T P S E D E A K A E T I R N L R K S F A S L F S D
Reactivity data
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application ELISA | Reactivity Reacts | Dilution info - | Notes - |
Application WB | Reactivity Reacts | Dilution info - | Notes - |
Target data
Function
May be involved in the regulation of neurotransmitter release and synaptogenesis.
Alternative names
Synapsin-3, Synapsin III, SYN3
Recommended products
Recombinant Human Synapsin III protein is a Human Full Length protein, in the 1 to 580 aa range, expressed in Wheat germ and suitable for ELISA, WB.
Key facts
- Expression system
- Wheat germ
- Tags
- GST tag N-Terminus
- Applications
- ELISA, WB
- Biologically active
- No
- Accession
- O14994-1
- Animal free
- No
- Species
- Human
- Concentration
- Storage buffer
pH: 8
Constituents: 0.79% Tris HCl, 0.31% Glutathione
Sequence info
Amino acid sequence
- M N F L R R R L S D S S F M A N L P N G Y M T D L Q R P D S S T S S P A S P A M E R R H P Q P L A A S F S S P G S S L F S S L S S A M K Q A P Q A T S G L M E P P G P S T P I V Q R P R I L L V I D D A H T D W S K Y F H G K K V N G E I E I R V E Q A E F S E L N L A A Y V T G G C M V D M Q V V R N G T K V V S R S F K P D F I L V R Q H A Y S M A L G E D Y R S L V I G L Q Y G G L P A V N S L Y S V Y N F C S K P W V F S Q L I K I F H S L G P E K F P L V E Q T F F P N H K P M V T A P H F P V V V K L G H A H A G M G K I K V E N Q L D F Q D I T S V V A M A K T Y A T T E A F I D S K Y D I R I Q K I G S N Y K A Y M R T S I S G N W K A N T G S A M L E Q V A M T E R Y R L W V D S C S E M F G G L D I C A V K A V H S K D G R D Y I I E V M D S S M P L I G E H V E E D R Q L M A D L V V S K M S Q L P M P G G T A P S P L R P W A P Q I K S A K S P G Q A Q L G P Q L G Q P Q P R P P P Q G G P R Q A Q S P Q P Q R S G S P S Q Q R L S P Q G Q Q P L S P Q S G S P Q Q Q R S P G S P Q L S R A S S G S S P N Q A S K P G A T L A S Q P R P P V Q G R S T S Q Q G E E S K K P A P P H P H L N K S Q S L T N S L S T S D T S Q R G T P S E D E A K A E T I R N L R K S F A S L F S D
- Accession
- O14994
- Protein length
- Full Length
- Amino acids
- 1 to 580
- Nature
- Recombinant
- Tags
- GST tag N-Terminus
Specifications
- Form
- Liquid
General info
- Function
May be involved in the regulation of neurotransmitter release and synaptogenesis.
- Sequence similarities
Belongs to the synapsin family.
- Post-translational modifications
Phosphorylation at Ser-9 dissociates synapsins from synaptic vesicles.
Storage
- Shipped at conditions
- Dry Ice
- Appropriate short-term storage conditions
- -80°C
- Appropriate long-term storage conditions
- -80°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
Synapsin III also known as SYNIII is a phosphoprotein with an approximate mass of 64 kDa. Like other synapsins Synapsin III is mostly found in the brain where it plays an important role in synaptic function. It shows a widespread expression with notable abundance in the hippocampus and cerebral cortex. The protein associates with synaptic vesicles and neuronal membranes assisting in neurotransmitter release during neuronal communication.
- Biological function summary
Synapsin III serves an important function in the regulation of neurotransmitter release and synaptic plasticity. It binds to synaptic vesicles and cytoskeletal elements organizing vesicle trafficking at the presynaptic terminal. Synapsin III is not part of a known larger protein complex but often works in concert with other synaptic proteins to influence synaptic vesicle dynamics. Its regulation of vesicle mobilization and docking highlights its function in fine-tuning neuronal communication.
- Pathways
Synapsin III operates in nerve terminal signaling especially in pathways involving synaptic vesicle cycle. It contributes to processes in the synaptic vesicle cycle details of which comprise vesicle trafficking and neurotransmitter release. In these pathways it interacts with proteins such as Synapsin I and Synapsin II which share responsibilities in neurotransmitter regulation. These proteins together maintain synaptic activity under various physiological conditions.
- Associated diseases and disorders
Synapsin III has connections with neurological conditions such as schizophrenia and attention deficit hyperactivity disorder (ADHD). Studies indicate alterations in Synapsin III expression levels or function may contribute to synaptic impairments observed in these disorders. Additionally there is interaction with proteins like DISC1 (Disrupted in Schizophrenia 1) which further links Synapsin III to schizophrenia. Synapsin III sits in the broader context of synaptic proteins critical for normal cognitive functions.
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1 product image
SDS-PAGE - Recombinant Human Synapsin III protein (ab159969)
ab159969 on a 12.5% SDS-PAGE stained with Coomassie Blue.
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