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AB159969

Recombinant Human Synapsin III protein

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Recombinant Human Synapsin III protein is a Human Full Length protein, in the 1 to 580 aa range, expressed in Wheat germ, suitable for ELISA, WB.

View Alternative Names

Synapsin-3, Synapsin III, SYN3

1 Images
SDS-PAGE - Recombinant Human Synapsin III protein (AB159969)
  • SDS-PAGE

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SDS-PAGE - Recombinant Human Synapsin III protein (AB159969)

ab159969 on a 12.5% SDS-PAGE stained with Coomassie Blue.

Key facts

Expression system

Wheat germ

Tags

GST tag N-Terminus

Applications

WB, ELISA

applications

Biologically active

No

Accession

O14994

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 0.79% Tris HCl, 0.31% Glutathione

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MNFLRRRLSDSSFMANLPNGYMTDLQRPDSSTSSPASPAMERRHPQPLAASFSSPGSSLFSSLSSAMKQAPQATSGLMEPPGPSTPIVQRPRILLVIDDAHTDWSKYFHGKKVNGEIEIRVEQAEFSELNLAAYVTGGCMVDMQVVRNGTKVVSRSFKPDFILVRQHAYSMALGEDYRSLVIGLQYGGLPAVNSLYSVYNFCSKPWVFSQLIKIFHSLGPEKFPLVEQTFFPNHKPMVTAPHFPVVVKLGHAHAGMGKIKVENQLDFQDITSVVAMAKTYATTEAFIDSKYDIRIQKIGSNYKAYMRTSISGNWKANTGSAMLEQVAMTERYRLWVDSCSEMFGGLDICAVKAVHSKDGRDYIIEVMDSSMPLIGEHVEEDRQLMADLVVSKMSQLPMPGGTAPSPLRPWAPQIKSAKSPGQAQLGPQLGQPQPRPPPQGGPRQAQSPQPQRSGSPSQQRLSPQGQQPLSPQSGSPQQQRSPGSPQLSRASSGSSPNQASKPGATLASQPRPPVQGRSTSQQGEESKKPAPPHPHLNKSQSLTNSLSTSDTSQRGTPSEDEAKAETIRNLRKSFASLFSD","proteinLength":"Full Length","predictedMolecularWeight":null,"actualMolecularWeight":null,"aminoAcidEnd":580,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Wheat germ","accessionNumber":"O14994","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Dry Ice
Appropriate short-term storage conditions
-80°C
Appropriate long-term storage conditions
-80°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Synapsin III also known as SYNIII is a phosphoprotein with an approximate mass of 64 kDa. Like other synapsins Synapsin III is mostly found in the brain where it plays an important role in synaptic function. It shows a widespread expression with notable abundance in the hippocampus and cerebral cortex. The protein associates with synaptic vesicles and neuronal membranes assisting in neurotransmitter release during neuronal communication.
Biological function summary

Synapsin III serves an important function in the regulation of neurotransmitter release and synaptic plasticity. It binds to synaptic vesicles and cytoskeletal elements organizing vesicle trafficking at the presynaptic terminal. Synapsin III is not part of a known larger protein complex but often works in concert with other synaptic proteins to influence synaptic vesicle dynamics. Its regulation of vesicle mobilization and docking highlights its function in fine-tuning neuronal communication.

Pathways

Synapsin III operates in nerve terminal signaling especially in pathways involving synaptic vesicle cycle. It contributes to processes in the synaptic vesicle cycle details of which comprise vesicle trafficking and neurotransmitter release. In these pathways it interacts with proteins such as Synapsin I and Synapsin II which share responsibilities in neurotransmitter regulation. These proteins together maintain synaptic activity under various physiological conditions.

Synapsin III has connections with neurological conditions such as schizophrenia and attention deficit hyperactivity disorder (ADHD). Studies indicate alterations in Synapsin III expression levels or function may contribute to synaptic impairments observed in these disorders. Additionally there is interaction with proteins like DISC1 (Disrupted in Schizophrenia 1) which further links Synapsin III to schizophrenia. Synapsin III sits in the broader context of synaptic proteins critical for normal cognitive functions.
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Specifications

Form

Liquid

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General info

Function

May be involved in the regulation of neurotransmitter release and synaptogenesis.

Sequence similarities

Belongs to the synapsin family.

Post-translational modifications

Phosphorylation at Ser-9 dissociates synapsins from synaptic vesicles.

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Product protocols

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Target data

May be involved in the regulation of neurotransmitter release and synaptogenesis.
See full target information Synapsin-3
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Primary Antibodies

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