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AB132194

Recombinant Human Synaptogyrin 2 protein (GST tag N-Terminus)

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Recombinant Human Synaptogyrin 2 protein (GST tag N-Terminus) is a Human Full Length protein, in the 1 to 224 aa range, expressed in Wheat germ, suitable for SDS-PAGE, ELISA, WB.

View Alternative Names

UNQ352/PRO615, SYNGR2, Synaptogyrin-2, Cellugyrin

1 Images
SDS-PAGE - Recombinant Human Synaptogyrin 2 protein (GST tag N-Terminus) (AB132194)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human Synaptogyrin 2 protein (GST tag N-Terminus) (AB132194)

12.5% SDS-PAGE analysis of ab132194 stained with Coomassie Blue.

Key facts

Expression system

Wheat germ

Tags

GST tag N-Terminus

Applications

ELISA, WB, SDS-PAGE

applications

Biologically active

No

Accession

O43760

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 0.79% Tris HCl, 0.31% Glutathione

storage-buffer

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Complementary Products

Proteins & Peptides

AB153221

Recombinant Human USP24 protein (GST tag N-Terminus)

SDS-PAGE - Recombinant Human USP24 protein (GST tag N-Terminus) (AB153221)

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Cell Lines & Lysates

AB266072

Human SYNGR2 (Synaptogyrin 2) knockout HEK-293T cell line

Sanger Sequencing - Human SYNGR2 (Synaptogyrin 2) knockout HEK-293T cell line (AB266072)

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  • 0
Cell Lines & Lysates

AB263378

Human SYNGR2 (Synaptogyrin 2) knockout HEK-293T cell lysate

Sanger Sequencing - Human SYNGR2 (Synaptogyrin 2) knockout HEK-293T cell lysate (AB263378)

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  • 0
Primary Antibodies

AB106459

Anti-Synaptogyrin 2 antibody

Western blot - Anti-Synaptogyrin 2 antibody (AB106459)

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  • 0
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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MESGAYGAAKAGGSFDLRRFLTQPQVVARAVCLVFALIVFSCIYGEGYSNAHESKQMYCVFNRNEDACRYGSAIGVLAFLASAFFLVVDAYFPQISNATDRKYLVIGDLLFSALWTFLWFVGFCFLTNQWAVTNPKDVLVGADSVRAAITFSFFSIFSWGVLASLAYQRYKAGVDDFIQNYVDPTPDPNTAYASYPGASVDNYQQPPFTQNAETTEGYQPPPVY","proteinLength":"Full Length","predictedMolecularWeight":"50.27 kDa","actualMolecularWeight":null,"aminoAcidEnd":224,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Wheat germ","accessionNumber":"O43760","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Dry Ice
Appropriate short-term storage conditions
-80°C
Appropriate long-term storage conditions
-80°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Synaptogyrin 2 also known as SYNGR2 is a membrane protein with a known molecular weight of approximately 26.5 kDa. It is a component of the synaptogyrin family which consists of proteins located in neuronal and endocrine tissues. Synaptogyrin 2 is a tetraspan membrane protein found in the vesicles of presynaptic neurons where it plays a role in modulating neurotransmitter release at the synapse. Its presence is prominent in the brain as well as in other nerve tissues.
Biological function summary

This protein contributes to the regulation of synaptic transmission. Synaptogyrin 2 does not act alone; instead it interacts with other proteins forming a complex that helps in managing the availability and recycling of synaptic vesicles. This regulation is significant for maintaining neurotransmitter homeostasis in neural communication influencing synaptic plasticity and overall brain function.

Pathways

The function of Synaptogyrin 2 relates to the synaptic vesicle cycle and the neurotransmitter release pathway. It closely associates with proteins like synaptophysin and synaptotagmin which are essential for the process of synaptic vesicle exocytosis and endocytosis. Through these pathways Synaptogyrin 2 impacts the efficiency and fidelity of neurotransmission which are critical features of neuronal communication.

Impairments involving Synaptogyrin 2 affect neurological functions linking it to disorders such as schizophrenia and epilepsy. Its interaction with proteins like SNAP-25 and syntaxin emphasizes its role in ensuring proper synaptic transmission. Abnormalities in these interactions may lead to altered synaptic function contributing to the pathophysiology of these conditions. Understanding Synaptogyrin 2’s role in these disorders aids in developing targeted therapeutic approaches.
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Specifications

Form

Liquid

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General info

Function

May play a role in regulated exocytosis. In neuronal cells, modulates the localization of synaptophysin/SYP into synaptic-like microvesicles and may therefore play a role in the formation and/or the maturation of this vesicles. May also play a role in GLUT4 storage and transport to the plasma membrane.. (Microbial infection) May play a role in the assembly of cytoplasmic inclusion bodies required for SFTS phlebovirus replication.

Sequence similarities

Belongs to the synaptogyrin family.

Post-translational modifications

May be tyrosine phosphorylated by Src.

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Product protocols

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Target data

May play a role in regulated exocytosis. In neuronal cells, modulates the localization of synaptophysin/SYP into synaptic-like microvesicles and may therefore play a role in the formation and/or the maturation of this vesicles. May also play a role in GLUT4 storage and transport to the plasma membrane.. (Microbial infection) May play a role in the assembly of cytoplasmic inclusion bodies required for SFTS phlebovirus replication.
See full target information SYNGR2
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