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AB180346

Recombinant Human Synaptotagmin 3 protein (Cytoplasmic domain) (denatured) (His tag N-Terminus)

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Recombinant Human Synaptotagmin 3 protein (Cytoplasmic domain) (denatured) (His tag N-Terminus) is a Human Fragment protein, in the 76 to 590 aa range, expressed in Escherichia coli, with >85%, suitable for SDS-PAGE.

View Alternative Names

Synaptotagmin-3, Synaptotagmin III, SytIII, SYT3

1 Images
SDS-PAGE - Recombinant Human Synaptotagmin 3 protein (Cytoplasmic domain) (denatured) (His tag N-Terminus) (AB180346)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human Synaptotagmin 3 protein (Cytoplasmic domain) (denatured) (His tag N-Terminus) (AB180346)

15% SDS-PAGE analysis of ab180346 (3 μg)

Key facts

Purity

>85% SDS-PAGE

Expression system

Escherichia coli

Tags

His tag N-Terminus

Applications

SDS-PAGE

applications

Biologically active

No

Accession

Q9BQG1

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 10% Glycerol (glycerin, glycerine), 2.4% Urea, 0.32% Tris HCl

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MGSSHHHHHHSSGLVPRGSHMGSEFWKLCWVPWRDKGGSAVGGGPLRKDLGPGVGLAGLVGGGGHHLAAGLGGHPLLGGPHHHAHAAHHPPFAELLEPGSLGGSDTPEPSYLDMDSYPEAAAAAVAAGVKPSQTSPELPSEGGAGSGLLLLPPSGGGLPSAQSHQQVTSLAPTTRYPALPRPLTQQTLTSQPDPSSEERPPALPLPLPGGEEKAKLIGQIKPELYQGTGPGGRRSGGGPGSGEAGTGAPCGRISFALRYLYGSDQLVVRILQALDLPAKDSNGFSDPYVKIYLLPDRKKKFQTKVHRKTLNPVFNETFQFSVPLAELAQRKLHFSVYDFDRFSRHDLIGQVVLDNLLELAEQPPDRPLWRDIVEGGSEKADLGELNFSLCYLPTAGRLTVTIIKASNLKAMDLTGFSDPYVKASLISEGRRLKKRKTSIKKNTLNPTYNEALVFDVAPESVENVGLSIAVVDYDCIGHNEVIGVCRVGPDAADPHGREHWAEMLANPRKPVEHWHQLVEEKTVTSFTKGSKGLSEKENSE","proteinLength":"Fragment","predictedMolecularWeight":"57.7 kDa","actualMolecularWeight":null,"aminoAcidEnd":590,"aminoAcidStart":76,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q9BQG1","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Synaptotagmin 3 (SYT3) is a protein that participates in synaptic vesicle exocytosis. It serves as a calcium sensor and is part of the synaptotagmin family. The protein is around 47 kDa in mass. Synaptotagmin 3 has a cytoplasmic domain and is expressed mainly in neuronal tissues playing an important role in neurotransmitter release at synapses. It interacts with phospholipids in the cell membrane and assists in membrane fusion during neurotransmitter vesicle release.
Biological function summary

Synaptotagmin 3 contributes to regulated exocytosis by binding to calcium ions. It forms part of the vesicle fusion machinery working alongside other proteins involved in synaptic transmission. It interacts with SNARE proteins which are essential in vesicle attachment and fusion with the plasma membrane. These interactions help calibrate the precise fusion of neurotransmitter-containing vesicles with the neuronal cell membrane allowing efficient signaling between neurons.

Pathways

Synaptotagmin 3 influences neurotransmitter release and synaptic plasticity which are important for communication in the nervous system. It is an integral component of the synaptic vesicle trafficking pathway. SYT3 works in conjunction with proteins like syntaxin and SNAP-25 within the SNARE complex which facilitates the docking and fusion of synaptic vesicles. This ensures accurate neurotransmitter release in response to calcium influx into neurons.

Alterations in Synaptotagmin 3 function have links to neurological conditions such as epilepsy and schizophrenia. Research indicates that improper SYT3 activity may disrupt synaptic vesicle release leading to impaired neuronal signaling. In epilepsy disturbed calcium regulation and malfunction of SYT3 could affect excitatory and inhibitory balance. Additionally changes in interactions with other synaptotagmin family members and SNARE proteins can contribute to these disorders by altering neurotransmitter dynamics.
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Specifications

Form

Liquid

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General info

Function

Ca(2+) sensor involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain. Ca(2+) induces binding of the C2-domains to phospholipid membranes and to assembled SNARE-complexes; both actions contribute to triggering exocytosis (By similarity). Plays a role in dendrite formation by melanocytes (PubMed : 23999003).

Sequence similarities

Belongs to the synaptotagmin family.

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Product protocols

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Target data

Ca(2+) sensor involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain. Ca(2+) induces binding of the C2-domains to phospholipid membranes and to assembled SNARE-complexes; both actions contribute to triggering exocytosis (By similarity). Plays a role in dendrite formation by melanocytes (PubMed : 23999003).
See full target information SYT3
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