Recombinant Human SynCAM/CADM1 Protein Standard (His tag)
Be the first to review this product! Submit a review
|
(0 Publication)
Recombinant Human SynCAM/CADM1 Protein Standard (His tag) is a Human Fragment protein, expressed in HEK 293 cells, with >80%, suitable for sELISA, SDS-PAGE.
View Alternative Names
IGSF4, IGSF4A, NECL2, SYNCAM, TSLC1, CADM1, Cell adhesion molecule 1, Immunoglobulin superfamily member 4, Nectin-like protein 2, Spermatogenic immunoglobulin superfamily, Synaptic cell adhesion molecule, Tumor suppressor in lung cancer 1, IgSF4, NECL-2, SgIgSF, SynCAM, TSLC-1
- sELISA
Supplier Data
Sandwich ELISA - Recombinant Human SynCAM/CADM1 Protein Standard (His tag) (AB323025)
Sandwich ELISA with the capture antibody dilution at 2 µg/mL and detector antibody dilution at 0.5 µg/mL.
- SDS-PAGE
Supplier Data
SDS-PAGE - Recombinant Human SynCAM/CADM1 Protein Standard (His tag) (AB323025)
SDS-PAGE analysis of ab323025 under reducing conditions for 2ug protein.
Reactivity data
Product details
Sequence info
Properties and storage information
Shipped at conditions
Appropriate short-term storage conditions
Appropriate long-term storage conditions
Aliquoting information
Storage information
Specifications
Form
Liquid
General info
Function
Mediates homophilic cell-cell adhesion in a Ca(2+)-independent manner (PubMed : 12050160, PubMed : 22438059). Also mediates heterophilic cell-cell adhesion with CADM3 and NECTIN3 in a Ca(2+)-independent manner (By similarity). Interaction with CRTAM promotes natural killer (NK) cell cytotoxicity and interferon-gamma (IFN-gamma) secretion by CD8+ cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM1 in vivo (PubMed : 15811952). In mast cells, may mediate attachment to and promote communication with nerves (PubMed : 15905536). CADM1, together with MITF, is essential for development and survival of mast cells in vivo (PubMed : 22438059). By interacting with CRTAM and thus promoting the adhesion between CD8+ T-cells and CD8+ dendritic cells, regulates the retention of activated CD8+ T-cell within the draining lymph node (By similarity). Required for the intestinal retention of intraepithelial CD4+ CD8+ T-cells and, to a lesser extent, intraepithelial and lamina propria CD8+ T-cells and CD4+ T-cells (By similarity). Interaction with CRTAM promotes the adhesion to gut-associated CD103+ dendritic cells, which may facilitate the expression of gut-homing and adhesion molecules on T-cells and the conversion of CD4+ T-cells into CD4+ CD8+ T-cells (By similarity). Acts as a synaptic cell adhesion molecule and plays a role in the formation of dendritic spines and in synapse assembly (By similarity). May be involved in neuronal migration, axon growth, pathfinding, and fasciculation on the axons of differentiating neurons (By similarity). May play diverse roles in the spermatogenesis including in the adhesion of spermatocytes and spermatids to Sertoli cells and for their normal differentiation into mature spermatozoa (By similarity). Acts as a tumor suppressor in non-small-cell lung cancer (NSCLC) cells (PubMed : 11279526, PubMed : 12234973). May contribute to the less invasive phenotypes of lepidic growth tumor cells (PubMed : 12920246).. Isoform 5. (Microbial infection) Induces cell fusion in neuron infected by a neuropathogenic strain of measles. Interacts with measles hemagglutinin to trigger hyperfusogenic F-mediated membrane fusion and presumably transsynaptic cell-to-cell transmission of the virus.
Sequence similarities
Belongs to the nectin family.
Post-translational modifications
Glycosylation at Asn-67 and Asn-101 promotes adhesive binding and synapse induction.
Target data
Product promise
Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.
For licensing inquiries, please contact partnerships@abcam.com