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AB152715

Recombinant Human Syntaxin-5 protein (GST tag N-Terminus)

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Recombinant Human Syntaxin-5 protein (GST tag N-Terminus) is a Human Full Length protein, in the 1 to 301 aa range, expressed in Wheat germ, suitable for SDS-PAGE, ELISA, WB.

View Alternative Names

STX5A, STX5, Syntaxin-5

1 Images
SDS-PAGE - Recombinant Human Syntaxin-5 protein (GST tag N-Terminus) (AB152715)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human Syntaxin-5 protein (GST tag N-Terminus) (AB152715)

12.5% SDS-PAGE analysis of ab152715 stained with Coomassie Blue.

Key facts

Expression system

Wheat germ

Tags

GST tag N-Terminus

Applications

SDS-PAGE, ELISA, WB

applications

Biologically active

No

Accession

Q13190

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 0.79% Tris HCl, 0.31% Glutathione

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Product details

This product was previously labelled as Syntaxin 5A.
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Sequence info

[{"sequence":"MSCRDRTQEFLSACKSLQTRQNGIQTNKPALRAVRQRSEFTLMAKRIGKDLSNTFAKLEKLTILAKRKSLFDDKAVEIEELTYIIKQDINSLNKQIAQLQDFVRAKGSQSGRHLQTHSNTIVVSLQSKLASMSNDFKSVLEVRTENLKQQRSRREQFSRAPVSALPLAPNHLGGGAVVLGAESHASKDVAIDMMDSRTSQQLQLIDEQDSYIQSRADTMQNIESTIVELGSIFQQLAHMVKEQEETIQRIDENVLGAQLDVEAAHSEILKYFQSVTSNRWLMVKIFLILIVFFIIFVVFLA","proteinLength":"Full Length","predictedMolecularWeight":"58.74 kDa","actualMolecularWeight":null,"aminoAcidEnd":301,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Wheat germ","accessionNumber":"Q13190","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Dry Ice
Appropriate short-term storage conditions
-80°C
Appropriate long-term storage conditions
-80°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Syntaxin-5 also known as STX5 is a target protein with a molecular mass of around 35 kDa. It plays a central role in vesicle trafficking processes. Syntaxin-5 is part of the SNARE complex where it functions to mediate membrane fusion of vesicles essential for intracellular transport. The protein is expressed ubiquitously but has higher expression in brain and kidney tissues reflecting its diverse cellular functions.
Biological function summary

Syntaxin-5 is a critical component of the molecular machinery controlling vesicular transport. As a member of the Golgi apparatus Syntaxin-5 interacts within the SNARE complex to facilitate the precise delivery of cargo between endoplasmic reticulum and Golgi or Golgi to plasma membrane. Its role as a hub in intracellular transport highlights its importance in maintaining cellular homeostasis and ensuring the distribution of proteins and lipids.

Pathways

Syntaxin-5 sits prominently within intracellular trafficking routes particularly involved in the ER-Golgi transport and Golgi-to-plasma membrane pathways. It functions alongside proteins such as Bet1 and Membrin in vesicular transport processes. Together these proteins contribute to the maintenance of Golgi structure and the regulation of vesicle budding ensuring proper cellular logistics.

Syntaxin-5 has links to neurodegenerative conditions and metabolic syndromes. Notably disruptions in its function can relate to Alzheimer's disease where it affects amyloid precursor protein processing. Syntaxin-5 also interacts with proteins like Vti1a which is implicated in lysosomal storage disorders highlighting its broader relevance to diseases involving vesicle transport dysfunction.
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Specifications

Form

Liquid

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General info

Function

Mediates endoplasmic reticulum to Golgi transport. Together with p115/USO1 and GM130/GOLGA2, involved in vesicle tethering and fusion at the cis-Golgi membrane to maintain the stacked and inter-connected structure of the Golgi apparatus.. Isoform 2. Required for Golgi to endoplasmic reticulum retrogade transport, and for intra-Golgi transport.. (Microbial infection) Required for the efficient production of infectious virion during human cytomegalovirus infection. Mechanistically, participates in the formation of the cytoplasmic viral assembly compartment where tegument acquisition and envelopment occur.

Sequence similarities

Belongs to the syntaxin family.

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Product protocols

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Target data

Mediates endoplasmic reticulum to Golgi transport. Together with p115/USO1 and GM130/GOLGA2, involved in vesicle tethering and fusion at the cis-Golgi membrane to maintain the stacked and inter-connected structure of the Golgi apparatus.. Isoform 2. Required for Golgi to endoplasmic reticulum retrogade transport, and for intra-Golgi transport.. (Microbial infection) Required for the efficient production of infectious virion during human cytomegalovirus infection. Mechanistically, participates in the formation of the cytoplasmic viral assembly compartment where tegument acquisition and envelopment occur.
See full target information STX5
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