Recombinant Human Syntaxin 8 protein

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Syntaxin 8 also known as STX8 is a member of the SNARE protein family and plays an important role in intracellular vesicle trafficking. This protein has a molecular weight of approximately 28 kDa. It primarily locates on endosomal membranes and shows expression in various human tissues including the kidney and liver. Syntaxin 8 contributes to vesicle fusion processes which are necessary for proper cellular function.

Biological function summary

Syntaxin 8 participates in the formation of the SNARE complex. This complex facilitates the fusion between vesicle and target membranes an important step in endocytosis and intracellular transport. Syntaxin 8 in conjunction with other SNARE proteins such as VAMP8 and syntaxin 7 enables the sorting and movement of vesicular cargo within the cell. This function supports cellular activities by regulating the trafficking of proteins and lipids to their respective destinations.

Pathways

Syntaxin 8 operates predominantly within the endocytic and lysosomal pathways. It interacts with proteins such as VTI1B and syntaxin 7 to mediate early endosome fusion to late endosomes therefore promoting the maturation of endosomes to lysosomes. These interactions and pathways emphasize Syntaxin 8’s role in maintaining cellular homeostasis and regulating the turnover of cellular components.

Alterations in Syntaxin 8's function have been observed in neurodegenerative diseases and lysosomal storage disorders. For example its malfunction can contribute to the accumulation of waste products in neuronal cells a characteristic of some forms of neurodegeneration. Connections between Syntaxin 8 and other proteins involved in these diseases such as lysosomal-associated membrane protein 1 (LAMP1) highlight its importance in cellular waste management and recycling processes.