Recombinant Human Syntenin 2 protein is a Human Full Length protein, in the 1 to 292 aa range, expressed in Escherichia coli, with >95% purity and suitable for SDS-PAGE, MS.
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Key facts
- Purity
- >95% SDS-PAGE
- Expression system
- Escherichia coli
- Tags
- His tag N-Terminus
- Applications
- SDS-PAGE, MS
- Biologically active
- No
Amino acid sequence
M G S S H H H H H H S S G L V P R G S H M G S M S S L Y P S L E D L K V D Q A I Q A Q V R A S P K M P A L P V Q A T A I S P P P V L Y P N L A E L E N Y M G L S L S S Q E V Q E S L L Q I P E G D S T A V S G P G P G Q M V A P V T G Y S L G V R R A E I K P G V R E I H L C K D E R G K T G L R L R K V D Q G L F V Q L V Q A N T P A S L V G L R F G D Q L L Q I D G R D C A G W S S H K A H Q V V K K A S G D K I V V V V R D R P F Q R T V T M H K D S M G H V G F V I K K G K I V S L V K G S S A A R N G L L T N H Y V C E V D G Q N V I G L K D K K I M E I L A T A G N V V T L T I I P S V I Y E H M V K K L P P V L L H H T M D H S I P D A
Reactivity data
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
Application MS | Reactivity Reacts | Dilution info - | Notes - |
Target data
Function
Binds phosphatidylinositol 4,5-bisphosphate (PIP2). May play a role in the organization of nuclear PIP2, cell division and cell survival (PubMed:15961997).
Alternative names
SITAC18, SDCBP2, Syntenin-2, Similar to TACIP18, Syndecan-binding protein 2, SITAC
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Recombinant Human Syntenin 2 protein is a Human Full Length protein, in the 1 to 292 aa range, expressed in Escherichia coli, with >95% purity and suitable for SDS-PAGE, MS.
Key facts
- Purity
- >95% SDS-PAGE
- Expression system
- Escherichia coli
- Tags
- His tag N-Terminus
- Applications
- SDS-PAGE, MS
- Biologically active
- No
- Accession
- Q9H190-1
- Animal free
- No
- Species
- Human
- Concentration
- Storage buffer
pH: 8
Constituents: 10% Glycerol (glycerin, glycerine), 0.88% Sodium chloride, 0.32% Tris HCl, 0.02% (R*,R*)-1,4-Dimercaptobutan-2,3-diol
Sequence info
Amino acid sequence
- M G S S H H H H H H S S G L V P R G S H M G S M S S L Y P S L E D L K V D Q A I Q A Q V R A S P K M P A L P V Q A T A I S P P P V L Y P N L A E L E N Y M G L S L S S Q E V Q E S L L Q I P E G D S T A V S G P G P G Q M V A P V T G Y S L G V R R A E I K P G V R E I H L C K D E R G K T G L R L R K V D Q G L F V Q L V Q A N T P A S L V G L R F G D Q L L Q I D G R D C A G W S S H K A H Q V V K K A S G D K I V V V V R D R P F Q R T V T M H K D S M G H V G F V I K K G K I V S L V K G S S A A R N G L L T N H Y V C E V D G Q N V I G L K D K K I M E I L A T A G N V V T L T I I P S V I Y E H M V K K L P P V L L H H T M D H S I P D A
- Accession
- Q9H190
- Protein length
- Full Length
- Predicted molecular weight
- 34 kDa
- Amino acids
- 1 to 292
- Nature
- Recombinant
- Tags
- His tag N-Terminus
Specifications
- Form
- Liquid
- Additional notes
ab137151 is purified using conventional chromatography techniques.
General info
- Function
Binds phosphatidylinositol 4,5-bisphosphate (PIP2). May play a role in the organization of nuclear PIP2, cell division and cell survival (PubMed:15961997).
- Subcellular localisation
- Nucleus, Nucleolus, Nucleoplasm, Nucleus speckle
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage duration
- 1-2 weeks
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
Syntenin 2 also known as tacstd2 is a multifunctional protein with a molecular mass of approximately 32 kDa. It is an adaptor protein that facilitates various intracellular processes through its PDZ domains. Syntenin 2 establishes interactions with other proteins by binding to their C-terminal sequences. This protein is expressed in numerous human tissues including the lung liver and kidneys highlighting its widespread function across the body.
- Biological function summary
Syntenin 2 impacts cell signaling membrane trafficking and cytoskeletal organization. It functions within complexes that play roles in vital cellular communication processes. Syntenin 2 can interact with other proteins such as syndecans and various transmembrane proteins enabling pathways that regulate cell movement and communication. These interactions suggest its involvement in intracellular transport and signal transduction.
- Pathways
The role of Syntenin 2 centers on the regulation of the Wnt signaling and the VEGF pathway. It participates by anchoring signaling components in specific locations in the cell influencing cellular responses. Its association with proteins like axin in the Wnt pathway and VEGF receptors in the VEGF pathway shows its versatility in coordinating complex signal networks that affect cell proliferation survival and migration.
- Associated diseases and disorders
Syntenin 2 has shown associations with cancer and fibrosis. In cancers dysregulation of pathways involving Syntenin 2 such as the Wnt signaling can contribute to abnormal cell growth and metastasis. In fibrosis its interaction with fibronectin and integrins might initiate excessive extracellular matrix production leading to tissue scarring. Understanding Syntenin 2's interaction with these proteins could provide insights into therapeutic approaches for related diseases.
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1 product image
SDS-PAGE - Recombinant Human Syntenin 2 protein (ab137151)
15% SDS-PAGE analysis of 3 µg ab137151.
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