Recombinant Human Syntrophin alpha 1 protein is a Human Full Length protein, in the 1 to 505 aa range, expressed in Escherichia coli, with >85% purity and suitable for SDS-PAGE, MS.
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Key facts
- Purity
- >85% SDS-PAGE
- Expression system
- Escherichia coli
- Tags
- His tag N-Terminus
- Applications
- SDS-PAGE, MS
- Biologically active
- No
Amino acid sequence
M G S S H H H H H H S S G L V P R G S H M G S M A S G R R A P R T G L L E L R A G A G S G A G G E R W Q R V L L S L A E D V L T V S P A D G D P G P E P G A P R E Q E P A Q L N G A A E P G A G P P Q L P E A L L L Q R R R V T V R K A D A G G L G I S I K G G R E N K M P I L I S K I F K G L A A D Q T E A L F V G D A I L S V N G E D L S S A T H D E A V Q V L K K T G K E V V L E V K Y M K D V S P Y F K N S T G G T S V G W D S P P A S P L Q R Q P S S P G P T P R N F S E A K H M S L K M A Y V S K R C T P N D P E P R Y L E I C S A D G Q D T L F L R A K D E A S A R S W A T A I Q A Q V N T L T P R V K D E L Q A L L A A T S T A G S Q D I K Q I G W L T E Q L P S G G T A P T L A L L T E K E L L L Y L S L P E T R E A L S R P A R T A P L I A T R L V H S G P S K G S V P Y D A E L S F A L R T G T R H G V D T H L F S V E S P Q E L A A W T R Q L V D G C H R A A E G V Q E V S T A C T W N G R P C S L S V H I D K G F T L W A A E P G A A R A V L L R Q P F E K L Q M S S D D G A S L L F L D F G G A E G E I Q L D L H S C P K T I V F I I H S F L S A K V T R L G L L A
Reactivity data
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
Application MS | Reactivity Reacts | Dilution info - | Notes - |
Target data
Function
Adapter protein that binds to and probably organizes the subcellular localization of a variety of membrane proteins. May link various receptors to the actin cytoskeleton and the extracellular matrix via the dystrophin glycoprotein complex. Plays an important role in synapse formation and in the organization of UTRN and acetylcholine receptors at the neuromuscular synapse. Binds to phosphatidylinositol 4,5-bisphosphate (By similarity).
Alternative names
SNT1, SNTA1, Alpha-1-syntrophin, 59 kDa dystrophin-associated protein A1 acidic component 1, Pro-TGF-alpha cytoplasmic domain-interacting protein 1, Syntrophin-1, TACIP1
Recommended products
Recombinant Human Syntrophin alpha 1 protein is a Human Full Length protein, in the 1 to 505 aa range, expressed in Escherichia coli, with >85% purity and suitable for SDS-PAGE, MS.
Key facts
- Purity
- >85% SDS-PAGE
- Expression system
- Escherichia coli
- Tags
- His tag N-Terminus
- Applications
- SDS-PAGE, MS
- Biologically active
- No
- Accession
- Q13424-1
- Animal free
- No
- Species
- Human
- Concentration
- Storage buffer
pH: 8
Constituents: 10% Glycerol (glycerin, glycerine), 0.88% Sodium chloride, 0.32% Tris HCl, 0.02% (R*,R*)-1,4-Dimercaptobutan-2,3-diol
Sequence info
Amino acid sequence
- M G S S H H H H H H S S G L V P R G S H M G S M A S G R R A P R T G L L E L R A G A G S G A G G E R W Q R V L L S L A E D V L T V S P A D G D P G P E P G A P R E Q E P A Q L N G A A E P G A G P P Q L P E A L L L Q R R R V T V R K A D A G G L G I S I K G G R E N K M P I L I S K I F K G L A A D Q T E A L F V G D A I L S V N G E D L S S A T H D E A V Q V L K K T G K E V V L E V K Y M K D V S P Y F K N S T G G T S V G W D S P P A S P L Q R Q P S S P G P T P R N F S E A K H M S L K M A Y V S K R C T P N D P E P R Y L E I C S A D G Q D T L F L R A K D E A S A R S W A T A I Q A Q V N T L T P R V K D E L Q A L L A A T S T A G S Q D I K Q I G W L T E Q L P S G G T A P T L A L L T E K E L L L Y L S L P E T R E A L S R P A R T A P L I A T R L V H S G P S K G S V P Y D A E L S F A L R T G T R H G V D T H L F S V E S P Q E L A A W T R Q L V D G C H R A A E G V Q E V S T A C T W N G R P C S L S V H I D K G F T L W A A E P G A A R A V L L R Q P F E K L Q M S S D D G A S L L F L D F G G A E G E I Q L D L H S C P K T I V F I I H S F L S A K V T R L G L L A
- Accession
- Q13424
- Protein length
- Full Length
- Predicted molecular weight
- 56.3 kDa
- Amino acids
- 1 to 505
- Nature
- Recombinant
- Tags
- His tag N-Terminus
Specifications
- Form
- Liquid
- Additional notes
ab116180 was purified using conventional chromatography techniques.
General info
- Function
Adapter protein that binds to and probably organizes the subcellular localization of a variety of membrane proteins. May link various receptors to the actin cytoskeleton and the extracellular matrix via the dystrophin glycoprotein complex. Plays an important role in synapse formation and in the organization of UTRN and acetylcholine receptors at the neuromuscular synapse. Binds to phosphatidylinositol 4,5-bisphosphate (By similarity).
- Sequence similarities
Belongs to the syntrophin family.
- Post-translational modifications
Phosphorylated by CaM-kinase II. Phosphorylation may inhibit the interaction with DMD (By similarity).
- Subcellular localisation
- Cytoskeleton
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage duration
- 1-2 weeks
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
Syntrophin alpha 1 also known as SNTA1 or by its protein mass of about 53 kDa is an adaptor protein that plays an important role in linking the cytoskeleton to the cell membrane. It interacts with ion channels receptors and signaling proteins at the membrane. Syntrophin alpha 1 forms part of the dystrophin-associated protein complex important for structural integrity and signaling processes in muscle tissue. This protein sees expression mainly in skeletal and cardiac muscles as well as in the brain where it contributes to signal transduction and cellular architecture.
- Biological function summary
Syntrophin alpha 1 contributes to maintaining muscular and neural function by organizing protein complexes at the cell membrane. It anchors various signaling molecules and is part of the dystrophin-glycoprotein complex. This involvement helps stabilize the muscle cell membrane during contraction and impact preventing damage. In neurons it modulates synaptic signaling and assists in maintaining cellular organization. The precise coordination of this protein with others in its complex ensures proper physiological responses to environmental stimuli.
- Pathways
Syntrophin alpha 1 is a component of signaling pathways related to muscle contraction and neurological processes. It interfaces with the PI3K/AKT signaling pathway connected to cellular growth and the nitric oxide pathway that regulates muscle blood flow. Syntrophin alpha 1 is closely related to dystrophin in these pathways and together they interface with neuronal nitric oxide synthase (nNOS) modulating blood flow and synaptic activity. This partnership not only regulates physiological functions but also maintains cellular stability during stress.
- Associated diseases and disorders
Alterations in syntrophin alpha 1 are associated with muscular dystrophies and cardiac conditions. Its malfunction contributes to disorders such as Duchenne muscular dystrophy where the absence of dystrophin disrupts the syntrophin-mediated membrane stability. Furthermore SNTA1 mutations can lead to long QT syndrome affecting cardiac electrical activity. In both cases the disturbance in syntrophin's interaction with dystrophin and nNOS contributes to disease progression leading to impaired muscle or cardiac function.
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2 product images
SDS-PAGE - Recombinant Human Syntrophin alpha 1 protein (ab116180)
ab116180 (3μg) analysed on a 15% SDS-PAGE gel.
SDS-PAGE - Recombinant Human Syntrophin alpha 1 protein (ab116180)
SDS-PAGE analysis of ab116180 (3µg).
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