JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB116180

Recombinant Human Syntrophin alpha 1 protein

Be the first to review this product! Submit a review

|

(0 Publication)

Recombinant Human Syntrophin alpha 1 protein is a Human Full Length protein, in the 1 to 505 aa range, expressed in Escherichia coli, with >85%, suitable for SDS-PAGE, Mass Spec.

View Alternative Names

SNT1, SNTA1, Alpha-1-syntrophin, 59 kDa dystrophin-associated protein A1 acidic component 1, Pro-TGF-alpha cytoplasmic domain-interacting protein 1, Syntrophin-1, TACIP1

2 Images
SDS-PAGE - Recombinant Human Syntrophin alpha 1 protein (AB116180)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human Syntrophin alpha 1 protein (AB116180)

SDS-PAGE analysis of ab116180 (3µg).

SDS-PAGE - Recombinant Human Syntrophin alpha 1 protein (AB116180)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human Syntrophin alpha 1 protein (AB116180)

ab116180 (3μg) analysed on a 15% SDS-PAGE gel.

Key facts

Purity

>85% SDS-PAGE

Expression system

Escherichia coli

Tags

His tag N-Terminus

Applications

SDS-PAGE, Mass Spec

applications

Biologically active

No

Accession

Q13424

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 10% Glycerol (glycerin, glycerine), 0.88% Sodium chloride, 0.32% Tris HCl, 0.02% (R*,R*)-1,4-Dimercaptobutan-2,3-diol

storage-buffer

style
left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "Mass Spec": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
style
left-column
style
left-column

Sequence info

[{"sequence":"MGSSHHHHHHSSGLVPRGSHMGSMASGRRAPRTGLLELRAGAGSGAGGERWQRVLLSLAEDVLTVSPADGDPGPEPGAPREQEPAQLNGAAEPGAGPPQLPEALLLQRRRVTVRKADAGGLGISIKGGRENKMPILISKIFKGLAADQTEALFVGDAILSVNGEDLSSATHDEAVQVLKKTGKEVVLEVKYMKDVSPYFKNSTGGTSVGWDSPPASPLQRQPSSPGPTPRNFSEAKHMSLKMAYVSKRCTPNDPEPRYLEICSADGQDTLFLRAKDEASARSWATAIQAQVNTLTPRVKDELQALLAATSTAGSQDIKQIGWLTEQLPSGGTAPTLALLTEKELLLYLSLPETREALSRPARTAPLIATRLVHSGPSKGSVPYDAELSFALRTGTRHGVDTHLFSVESPQELAAWTRQLVDGCHRAAEGVQEVSTACTWNGRPCSLSVHIDKGFTLWAAEPGAARAVLLRQPFEKLQMSSDDGASLLFLDFGGAEGEIQLDLHSCPKTIVFIIHSFLSAKVTRLGLLA","proteinLength":"Full Length","predictedMolecularWeight":"56.3 kDa","actualMolecularWeight":null,"aminoAcidEnd":505,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q13424","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
style
left-column

Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
style
left-column

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Syntrophin alpha 1 also known as SNTA1 or by its protein mass of about 53 kDa is an adaptor protein that plays an important role in linking the cytoskeleton to the cell membrane. It interacts with ion channels receptors and signaling proteins at the membrane. Syntrophin alpha 1 forms part of the dystrophin-associated protein complex important for structural integrity and signaling processes in muscle tissue. This protein sees expression mainly in skeletal and cardiac muscles as well as in the brain where it contributes to signal transduction and cellular architecture.
Biological function summary

Syntrophin alpha 1 contributes to maintaining muscular and neural function by organizing protein complexes at the cell membrane. It anchors various signaling molecules and is part of the dystrophin-glycoprotein complex. This involvement helps stabilize the muscle cell membrane during contraction and impact preventing damage. In neurons it modulates synaptic signaling and assists in maintaining cellular organization. The precise coordination of this protein with others in its complex ensures proper physiological responses to environmental stimuli.

Pathways

Syntrophin alpha 1 is a component of signaling pathways related to muscle contraction and neurological processes. It interfaces with the PI3K/AKT signaling pathway connected to cellular growth and the nitric oxide pathway that regulates muscle blood flow. Syntrophin alpha 1 is closely related to dystrophin in these pathways and together they interface with neuronal nitric oxide synthase (nNOS) modulating blood flow and synaptic activity. This partnership not only regulates physiological functions but also maintains cellular stability during stress.

Alterations in syntrophin alpha 1 are associated with muscular dystrophies and cardiac conditions. Its malfunction contributes to disorders such as Duchenne muscular dystrophy where the absence of dystrophin disrupts the syntrophin-mediated membrane stability. Furthermore SNTA1 mutations can lead to long QT syndrome affecting cardiac electrical activity. In both cases the disturbance in syntrophin's interaction with dystrophin and nNOS contributes to disease progression leading to impaired muscle or cardiac function.
style
left-column

Specifications

Form

Liquid

Additional notes

ab116180 was purified using conventional chromatography techniques.

style
left-column

General info

Function

Adapter protein that binds to and probably organizes the subcellular localization of a variety of membrane proteins. May link various receptors to the actin cytoskeleton and the extracellular matrix via the dystrophin glycoprotein complex. Plays an important role in synapse formation and in the organization of UTRN and acetylcholine receptors at the neuromuscular synapse. Binds to phosphatidylinositol 4,5-bisphosphate (By similarity).

Sequence similarities

Belongs to the syntrophin family.

Post-translational modifications

Phosphorylated by CaM-kinase II. Phosphorylation may inhibit the interaction with DMD (By similarity).

Subcellular localisation

Cytoskeleton

style
left-column

Product protocols

style
left-column

Target data

Adapter protein that binds to and probably organizes the subcellular localization of a variety of membrane proteins. May link various receptors to the actin cytoskeleton and the extracellular matrix via the dystrophin glycoprotein complex. Plays an important role in synapse formation and in the organization of UTRN and acetylcholine receptors at the neuromuscular synapse. Binds to phosphatidylinositol 4,5-bisphosphate (By similarity).
See full target information SNTA1
style
left-column
style
left-column
style
right-column

Complementary Products

Proteins & Peptides

AB131676

Recombinant Human TWF1/Twinfilin-1 protein

SDS-PAGE - Recombinant Human TWF1/Twinfilin-1 protein (AB131676)

  • 0
  • 0
Proteins & Peptides

AB116154

Recombinant Human PSMA8 protein

SDS-PAGE - Recombinant Human PSMA8 protein (AB116154)

  • 0
  • 0
Proteins & Peptides

AB115721

Recombinant Human PSMB4 protein

SDS-PAGE - Recombinant Human PSMB4 protein (AB115721)

  • 0
  • 0
Proteins & Peptides

AB116197

Recombinant Human WHSC2/NELF-A protein

SDS-PAGE - Recombinant Human WHSC2/NELF-A protein (AB116197)

  • 0
  • 0

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com