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AB171703

Recombinant Human TADA3L protein

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Recombinant Human TADA3L protein is a Human Full Length protein, in the 1 to 432 aa range, expressed in Escherichia coli, with >80%, suitable for SDS-PAGE.

View Alternative Names

ADA3, TADA3L, TADA3, Transcriptional adapter 3, ADA3 homolog, STAF54, Transcriptional adapter 3-like, hADA3, ADA3-like protein

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SDS-PAGE - Recombinant Human TADA3L protein (AB171703)
  • SDS-PAGE

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SDS-PAGE - Recombinant Human TADA3L protein (AB171703)

15% SDS-PAGE analysis of ab171703 (3μg).

Key facts

Purity

>80% SDS-PAGE

Expression system

Escherichia coli

Tags

His tag N-Terminus

Applications

SDS-PAGE

applications

Biologically active

No

Accession

O75528

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 50% Glycerol (glycerin, glycerine), 1.17% Sodium chloride, 0.32% Tris HCl, 0.03% (R*,R*)-1,4-Dimercaptobutan-2,3-diol

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MGSSHHHHHHSSGLVPRGSHMGSMSELKDCPLQFHDFKSVDHLKVCPRYTAVLARSEDDGIGIEELDTLQLELETLLSSASRRLRVLEAETQILTDWQDKKGDRRFLKLGRDHELGAPPKHGKPKKQKLEGKAGHGPGPGPGRPKSKNLQPKIQEYEFTDDPIDVPRIPKNDAPNRFWASVEPYCADITSEEVRTLEELLKPPEDEAEHYKIPPLGKHYSQRWAQEDLLEEQKDGARAAAVADKKKGLMGPLTELDTKDVDALLKKSEAQHEQPEDGCPFGALTQRLLQALVEENIISPMEDSPIPDMSGKESGADGASTSPRNQNKPFSVPHTKSLESRIKEELIAQGLLESEDRPAEDSEDEVLAELRKRQAELKALSAHNRTKKHDLLRLAKEEVSRQELRQRVRMADNEVMDAFRKIMAARQKKRTPTKKEKDQAWKTLKERESILKLLDG","proteinLength":"Full Length","predictedMolecularWeight":"51.3 kDa","actualMolecularWeight":null,"aminoAcidEnd":432,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"O75528","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

TADA3L also known as Transcriptional Adaptor 3-Like is part of the larger transcriptional coactivator complexes. The protein has a mass of approximately 55 kDa and is expressed in various tissues including liver and kidney. Mechanically TADA3L acts as a transcriptional adaptor interacting with DNA-binding transcription factors and assisting the recruitment of additional coactivators necessary for gene transcription.
Biological function summary

The protein assists in regulating gene expression by serving as a component of the human Ada-Two-A containing (hATAC) complex. The hATAC complex which includes TADA3L plays a role in histone acetylation allowing chromatin to be more accessible for transcriptional machinery. TADA3L's involvement in this complex underlines its role in modulating transcription and influencing cell cycle and proliferation processes.

Pathways

The TADA3L protein integrates into networks influencing transcriptional regulation and chromatin remodeling pathways. It associates with GCN5 and PCAF which are critical for histone acetyl transferase (HAT) activity within these pathways. Through its interaction with these proteins TADA3L contributes to the control of gene expression and is an important part of maintaining homeostasis in cellular function.

Alterations in TADA3L function or expression link to cancer and developmental disorders. Mutations or deregulation of this protein can disrupt normal transcriptional regulation leading to oncogenesis. In cancer pathways TADA3L shows connections with proteins like p53 a widely studied tumor suppressor where its impairment could affect apoptotic and cell cycle arrest pathways contributing to tumor development.
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Specifications

Form

Liquid

Additional notes

ab171703 is purified using conventional chromatography techniques.

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General info

Function

Functions as a component of the PCAF complex. The PCAF complex is capable of efficiently acetylating histones in a nucleosomal context. The PCAF complex could be considered as the human version of the yeast SAGA complex. Also known as a coactivator for p53/TP53-dependent transcriptional activation. Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4.

Sequence similarities

Belongs to the NGG1 family.

Subcellular localisation

Nucleus

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Product protocols

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Target data

Functions as a component of the PCAF complex. The PCAF complex is capable of efficiently acetylating histones in a nucleosomal context. The PCAF complex could be considered as the human version of the yeast SAGA complex. Also known as a coactivator for p53/TP53-dependent transcriptional activation. Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4.
See full target information TADA3
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Complementary Products

Primary Antibodies

AB181984

Anti-TADA3L antibody [EPR13864]

RabMAb|Recombinant

Flow Cytometry (Intracellular) - Anti-TADA3L antibody [EPR13864] (AB181984)

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