Recombinant Human TAF1L protein

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

TAF1L also known as TATA-box binding protein-associated factor 1-like is mechanically an essential component of transcription initiation. This protein has a mass of approximately 211 kDa and participates in RNA polymerase II-driven transcription as part of the TFIID complex. Expressed in various tissues TAF1L plays an integral role in the transcriptional regulation of many genes especially those involved in early developmental processes.

Biological function summary

The function of TAF1L involves acting as a cofactor in RNA polymerase II transcription. TAF1L is part of the TFIID complex which also includes TBP and several other TAFs. This complex assists in the recognition of the core promoter sequences and is essential in the formation of the transcription preinitiation complex. Beyond general transcription tasks TAF1L modifies chromatin structure to facilitate the binding of other transcription machinery and potentially influences gene expression patterns specific to certain tissues.

Pathways

TAF1L interacts with components critical to the transcription machinery. It operates within the RNA polymerase II transcription initiation pathway aligning with other TAFs and TBP to recruit RNA polymerase II to the promoter regions of target genes. Furthermore TAF1L plays roles in pathways influencing chromatin remodeling interacting with histone modifying proteins to aid in transcription regulation. Both these pathways highlight the importance of TAF1L in regulating gene expression.

TAF1L connects to certain neurodevelopmental disorders like X-linked intellectual disability. Studies show significant interaction between TAF1L and TBP with mutations in these components contributing to transcriptional dysregulation. Additionally research suggests alterations in TAF1L may relate to conditions such as syndromic autism. Understanding TAF1L's interactions with proteins like TBP and their impact on transcription could provide insights into the molecular basis of these disorders.