Recombinant Human TAF1L protein
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Recombinant Human TAF1L protein is a Human Fragment protein, in the 1517 to 1649 aa range, expressed in Escherichia coli, with >89%, suitable for SDS-PAGE, FuncS.
View Alternative Names
Transcription initiation factor TFIID subunit 1-like, TAF(II)210, TBP-associated factor 1-like, TBP-associated factor 210 kDa, Transcription initiation factor TFIID 210 kDa subunit, TAF1L
- FuncS
Supplier Data
Functional Studies - Recombinant Human TAF1L protein (AB198128)
Activity assay using ab198128.
- SDS-PAGE
Supplier Data
SDS-PAGE - Recombinant Human TAF1L protein (AB198128)
4-20% SDS-PAGE analysis of ab198128 (1μg).
Reactivity data
Sequence info
Properties and storage information
Shipped at conditions
Appropriate short-term storage conditions
Appropriate long-term storage conditions
Storage information
Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
The function of TAF1L involves acting as a cofactor in RNA polymerase II transcription. TAF1L is part of the TFIID complex which also includes TBP and several other TAFs. This complex assists in the recognition of the core promoter sequences and is essential in the formation of the transcription preinitiation complex. Beyond general transcription tasks TAF1L modifies chromatin structure to facilitate the binding of other transcription machinery and potentially influences gene expression patterns specific to certain tissues.
Pathways
TAF1L interacts with components critical to the transcription machinery. It operates within the RNA polymerase II transcription initiation pathway aligning with other TAFs and TBP to recruit RNA polymerase II to the promoter regions of target genes. Furthermore TAF1L plays roles in pathways influencing chromatin remodeling interacting with histone modifying proteins to aid in transcription regulation. Both these pathways highlight the importance of TAF1L in regulating gene expression.
Specifications
Form
Liquid
General info
Function
May act as a functional substitute for TAF1/TAFII250 during male meiosis, when sex chromosomes are transcriptionally silenced.
Sequence similarities
Belongs to the TAF1 family.
Subcellular localisation
Nucleus
Target data
Complementary Products
Product promise
Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.
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