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AB276272

Recombinant Human TAG1/TAX1 protein (His tag)

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Recombinant Human TAG1/TAX1 protein (His tag) is a Human Fragment protein, in the 1 to 1012 aa range, expressed in HEK 293 cells, with >95%, < 1 EU/µg endotoxin level, suitable for SDS-PAGE.

View Alternative Names

AXT, TAG1, TAX1, CNTN2, Contactin-2, Axonal glycoprotein TAG-1, Axonin-1, Transient axonal glycoprotein 1, TAX-1

1 Images
SDS-PAGE - Recombinant Human TAG1/TAX1 protein (His tag) (AB276272)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human TAG1/TAX1 protein (His tag) (AB276272)

SDS-PAGE analysis of ab276272

Key facts

Purity

>95% SDS-PAGE

Endotoxin level

< 1 EU/µg

Expression system

HEK 293 cells

Tags

His tag C-Terminus

Applications

SDS-PAGE

applications

Biologically active

No

Accession

Q02246

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 7.5 Constituents: 0.75% Glycine, 0.61% Tris, 0.06% Sodium chloride

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MGTATRRKPHLLLVAAVALVSSSAWSSALGSQTTFGPVFEDQPLSVLFPEESTEEQVLLACRARASPPATYRWKMNGTEMKLEPGSRHQLVGGNLVIMNPTKAQDAGVYQCLASNPVGTVVSREAILRFGFLQEFSKEERDPVKAHEGWGVMLPCNPPAHYPGLSYRWLLNEFPNFIPTDGRHFVSQTTGNLYIARTNASDLGNYSCLATSHMDFSTKSVFSKFAQLNLAAEDTRLFAPSIKARFPAETYALVGQQVTLECFAFGNPVPRIKWRKVDGSLSPQWTTAEPTLQIPSVSFEDEGTYECEAENSKGRDTVQGRIIVQAQPEWLKVISDTEADIGSNLRWGCAAAGKPRPTVRWLRNGEPLASQNRVEVLAGDLRFSKLSLEDSGMYQCVAENKHGTIYASAELAVQALAPDFRLNPVRRLIPAARGGEILIPCQPRAAPKAVVLWSKGTEILVNSSRVTVTPDGTLIIRNISRSDEGKYTCFAENFMGKANSTGILSVRDATKITLAPSSADINLGDNLTLQCHASHDPTMDLTFTWTLDDFPIDFDKPGGHYRRTNVKETIGDLTILNAQLRHGGKYTCMAQTVVDSASKEATVLVRGPPGPPGGVVVRDIGDTTIQLSWSRGFDNHSPIAKYTLQARTPPAGKWKQVRTNPANIEGNAETAQVLGLTPWMDYEFRVIASNILGTGEPSGPSSKIRTREAAPSVAPSGLSGGGGAPGELIVNWTPMSREYQNGDGFGYLLSFRRQGSTHWQTARVPGADAQYFVYSNESVRPYTPFEVKIRSYNRRGDGPESLTALVYSAEEEPRVAPTKVWAKGVSSSEMNVTWEPVQQDMNGILLGYEIRYWKAGDKEAAADRVRTAGLDTSARVSGLHPNTKYHVTVRAYNRAGTGPASPSANATTMKPPPRRPPGNISWTFSSSSLSIKWDPVVPFRNESAVTGYKMLYQNDLHLTPTLHLTGKNWIEIPVPEDIGHALVQIRTTGPGGDGIPAEVHIVRNGGTSMMVEN","proteinLength":"Fragment","predictedMolecularWeight":"109 kDa","actualMolecularWeight":null,"aminoAcidEnd":1012,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"HEK 293 cells","accessionNumber":"Q02246","tags":[{"tag":"His","terminus":"C-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

TAG1 also known as TAX1 or contactin-2 is a protein encoded by the CNTN2 gene in humans. It is a member of the immunoglobulin superfamily and has a mass of approximately 140 kDa. TAG1 is expressed in the nervous system particularly in the peripheral and central nervous systems during development. It is predominantly found on neurons influencing axonal guidance and neuronal connectivity.
Biological function summary

TAG1 plays a fundamental role in the nervous system by mediating cell adhesion and signaling. It forms part of a complex often interacting with other cell adhesion molecules to facilitate cellular communication and neurite outgrowth. By influencing neuronal positioning and patterning TAG1 contributes to the proper formation of neural circuits.

Pathways

There is a strong involvement of TAG1 in axonal growth and guidance pathways as well as in the cell adhesion signaling pathway. It directly interacts with proteins such as Caspr and neurofascin which are critical for myelination and the maintenance of the node of Ranvier. These interactions help guide neuron development and function.

Altered expression of TAG1 has been linked to several neural disorders including autism spectrum disorders and schizophrenia. In the context of these diseases TAG1 interacts with other proteins such as contactin-associated protein 1 (Caspr1) which plays an important role in maintaining neural network stability and function. Understanding these interactions provides insights into the pathogenesis of these neurological conditions.
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Specifications

Form

Lyophilized

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General info

Function

In conjunction with another transmembrane protein, CNTNAP2, contributes to the organization of axonal domains at nodes of Ranvier by maintaining voltage-gated potassium channels at the juxtaparanodal region. May be involved in cell adhesion.

Sequence similarities

Belongs to the immunoglobulin superfamily. Contactin family.

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Product protocols

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Target data

In conjunction with another transmembrane protein, CNTNAP2, contributes to the organization of axonal domains at nodes of Ranvier by maintaining voltage-gated potassium channels at the juxtaparanodal region. May be involved in cell adhesion.
See full target information CNTN2
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Product promise

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