Recombinant Human TAGLN/Transgelin protein
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Recombinant Human TAGLN/Transgelin protein is a Human Full Length protein, in the 1 to 201 aa range, expressed in Escherichia coli, with >85%, suitable for SDS-PAGE, Mass Spec, WB.
View Alternative Names
SM22, WS3-10, TAGLN, Transgelin, 22 kDa actin-binding protein, Protein WS3-10, Smooth muscle protein 22-alpha, SM22-alpha
- WB
Unknown
Western blot - Recombinant Human TAGLN/Transgelin protein (AB101469)
All lanes:
Western blot - Anti-TAGLN/Transgelin antibody (<a href='/en-us/products/primary-antibodies/tagln-transgelin-antibody-ab14106'>ab14106</a>) at 1 µg/mL
Lane 1:
Western blot - Recombinant Human TAGLN/Transgelin protein (ab101469) at 0.01 µg
Lane 1:
Western blot - Recombinant Human SPG21/Maspardin protein (<a href='/en-us/products/proteins-peptides/recombinant-human-spg21-maspardin-protein-ab86438'>ab86438</a>)
Secondary
All lanes:
Western blot - Goat Anti-Rabbit IgG H&L (HRP) preadsorbed (<a href='/en-us/products/secondary-antibodies/goat-rabbit-igg-h-l-hrp-preadsorbed-ab97080'>ab97080</a>) at 1/5000 dilution
Predicted band size: 23 kDa,35 kDa
true
Exposure time: 30s
- SDS-PAGE
Supplier Data
SDS-PAGE - Recombinant Human TAGLN/Transgelin protein (AB101469)
SDS-PAGE analysis of ab101469 (3µg).
Reactivity data
Product details
Sequence info
Properties and storage information
Shipped at conditions
Appropriate short-term storage conditions
Appropriate long-term storage conditions
Aliquoting information
Storage information
Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
The regulatory involvement of TAGLN in smooth muscle contraction influences cellular activities essential for vascular function. This protein modulates remodeling and differentiation within smooth muscle cells. It can associate with actin and calponin to form complexes that regulate the stability of cytoskeletal structures ensuring effective cellular responses to mechanical stimuli. By linking signal transduction to cytoskeletal mechanics TAGLN facilitates the maintenance of cell shape and tension.
Pathways
TAGLN plays a role in the regulation of the RhoA/Rho kinase pathway contributing to actin cytoskeleton organization and smooth muscle contraction. Additionally it is involved in the WNT signaling pathway influencing cell proliferation and differentiation. In these pathways TAGLN works with proteins like RhoA and beta-catenin to transmit signals from the extracellular environment to the nucleus impacting gene expression and cellular responses.
Specifications
Form
Liquid
Additional notes
ab101469 was purified using conventional chromatography techniques.
General info
Function
Actin cross-linking/gelling protein (By similarity). Involved in calcium interactions and contractile properties of the cell that may contribute to replicative senescence.
Sequence similarities
Belongs to the calponin family.
Target data
Complementary Products
Product promise
Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.
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