Recombinant Human TANK/TRAF2 protein
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Recombinant Human TANK/TRAF2 protein is a Human Full Length protein, in the 1 to 448 aa range, expressed in Escherichia coli, with >85%, suitable for SDS-PAGE.
View Alternative Names
ITRAF, TRAF2, TANK, TRAF family member-associated NF-kappa-B activator, TRAF-interacting protein, I-TRAF
- SDS-PAGE
Unknown
SDS-PAGE - Recombinant Human TANK/TRAF2 protein (AB140046)
15% SDS-PAGE analysis of ab140046 (3μg).
Reactivity data
Product details
Sequence info
Properties and storage information
Shipped at conditions
Appropriate short-term storage conditions
Appropriate long-term storage conditions
Aliquoting information
Storage information
Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
The TANK/TRAF2 complex plays a role in modulating the NF-kappa-B signaling pathway which is important for inflammation and immune responses. This complex also contributes to cellular responses to stress and infection. TANK acts as an adaptor protein that interacts with TRAF2 to relay signals from upstream receptors ensuring proper immune function. Additionally TANK inhibits excessive activation of NF-kappa-B maintaining a balanced immune response.
Pathways
As it relates to regulating immune functions TANK/TRAF2 is pivotal in the NF-kappa-B and MAPK signaling pathways. In the NF-kappa-B pathway TRAF2 helps mediate the activation of downstream kinases which are critical for the translocation of NF-kappa-B to the nucleus. TANK works alongside other signaling molecules like TRAF3 and TRAF6 integrating signals that lead to gene transcription involved in immune response and cell survival.
Specifications
Form
Liquid
Additional notes
ab140046 was purified by using conventional chromatography techniques.
General info
Function
Adapter protein involved in I-kappa-B-kinase (IKK) regulation which constitutively binds TBK1 and IKBKE playing a role in antiviral innate immunity. Acts as a regulator of TRAF function by maintaining them in a latent state. Blocks TRAF2 binding to LMP1 and inhibits LMP1-mediated NF-kappa-B activation. Negatively regulates NF-kappaB signaling and cell survival upon DNA damage (PubMed : 25861989). Plays a role as an adapter to assemble ZC3H12A, USP10 in a deubiquitination complex which plays a negative feedback response to attenuate NF-kappaB activation through the deubiquitination of IKBKG or TRAF6 in response to interleukin-1-beta (IL1B) stimulation or upon DNA damage (PubMed : 25861989). Promotes UBP10-induced deubiquitination of TRAF6 in response to DNA damage (PubMed : 25861989). May control negatively TRAF2-mediated NF-kappa-B activation signaled by CD40, TNFR1 and TNFR2.
Post-translational modifications
Phosphorylated by IKBKE.. (Microbial infection) Cleaved by encephalomyocarditis virus (EMCV) protease 3C (PubMed:26363073). This cleavage allows the virus to disrupt the TANK-TBK1-IKKepsilon-IRF3 complex, thereby inhibiting the induction of the IFN-beta signal pathway (PubMed:28487378).. (Microbial infection) Cleaved by Seneca Valley virus protease 3C allowing the virus to suppress interferon type-I through both RIG-I and Toll-like receptor-dependent pathways.
Target data
Complementary Products
Product promise
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