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AB126654

Recombinant Human TATDN3 protein

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(1 Publication)

Recombinant Human TATDN3 protein is a Human Full Length protein, in the 1 to 274 aa range, expressed in Escherichia coli, with >90%, suitable for SDS-PAGE, Mass Spec.

View Alternative Names

Putative deoxyribonuclease TATDN3, TATDN3

1 Images
SDS-PAGE - Recombinant Human TATDN3 protein (AB126654)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human TATDN3 protein (AB126654)

15% SDS-PAGE showing ab126654 (3µg).

Key facts

Purity

>90% SDS-PAGE

Expression system

Escherichia coli

Tags

His tag N-Terminus

Applications

Mass Spec, SDS-PAGE

applications

Biologically active

No

Accession

Q17R31

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 20% Glycerol (glycerin, glycerine), 1.17% Sodium chloride, 0.32% Tris HCl, 0.02% (R*,R*)-1,4-Dimercaptobutan-2,3-diol

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "Mass Spec": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MGSSHHHHHHSSGLVPRGSHMGSHMRAAGVGLVDCHCHLSAPDFDRDLDDVLEKAKKANVVALVAVAEHSGEFEKIMQLSERYNGFVLPCLGVHPVQGLPPEDQRSVTLKDLDVALPIIENYKDRLLAIGEVGLDFSPRFAGTGEQKEEQRQVLIRQIQLAKRLNLPVNVHSRSAGRPTINLLQEQGAEKVLLHAFDGRPSVAMEGVRAGYFFSIPPSIIRSGQKQKLVKQLPLTSICLETDSPALGPEKQVRNEPWNISISAEYIAQVKGISVEEVIEVTTQNALKLFPKLRHLLQK","proteinLength":"Full Length","predictedMolecularWeight":"32.9 kDa","actualMolecularWeight":null,"aminoAcidEnd":274,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q17R31","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

TATDN3 also known as TatD-like DNase domain-containing protein 3 functions primarily as a deoxyribonuclease. It exhibits DNA-binding and ribonuclease activities. The protein has a molecular weight of approximately 33 kDa. TATDN3 is highly expressed in various human tissues with notable presence in the brain muscle and kidney suggesting a pervasive role within different tissue types. Understanding its expression aids in grasping its mechanical role in cells.
Biological function summary

TATDN3 participates in the regulation of apoptosis and DNA repair processes. These are important for maintaining cellular integrity and responding to cellular stress. Although not part of a complex TATDN3 interacts with other proteins involved in similar roles within the cell. Its function in apoptosis highlights its importance in regulating cell death and survival protecting against abnormal cell proliferation.

Pathways

TATDN3 engages in the DNA damage response and apoptosis signaling pathways. Within these it interacts with proteins like p53 and BAX which serve key functions in cellular stress management. The DNA damage response pathway focuses on detecting and repairing damaged DNA while the apoptosis signaling pathway regulates programmed cell death. TATDN3's participation ensures proper cellular function and responds to genetic material stress.

TATDN3's role links to cancer and neurodegenerative diseases. In cancer deregulated apoptosis and DNA repair contribute to uncontrolled cell growth implicating this protein. Its association with proteins like p53 makes it a significant point of interest in oncological studies. In neurodegenerative diseases TATDN3's function in neural cell survival and stability connects to disease progression emphasizing its impact on neural health. Understanding this relationship offers potential therapeutic avenues.
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Specifications

Form

Liquid

Additional notes

ab126654 is purified using conventional chromatography techniques.

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General info

Function

Putative deoxyribonuclease.

Sequence similarities

Belongs to the metallo-dependent hydrolases superfamily. TatD-type hydrolase family.

Subcellular localisation

Nucleus

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Product protocols

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Target data

Putative deoxyribonuclease.
See full target information TATDN3
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Carcinogenesis 40:1415-1426 PubMed30963174

2019

β-hCG-induced mutant BRCA1 ignites drug resistance in susceptible breast tissue.

Applications

Unspecified application

Species

Unspecified reactive species

Satheesh Kumar Sengodan,Sreelatha K Hemalatha,Revathy Nadhan,Thara Somanathan,Arun Peter Mathew,Arkadiusz Chil,Janusz Kopczynski,Rakesh Sathish Nair,Jerald Mahesh Kumar,Priya Srinivas
View all publications
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