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AB202146

Recombinant Human TBC1D22B protein

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Recombinant Human TBC1D22B protein is a Human Full Length protein, in the 1 to 505 aa range, expressed in Escherichia coli, with >85%, suitable for SDS-PAGE.

View Alternative Names

C6orf197, TBC1D22B, TBC1 domain family member 22B

1 Images
SDS-PAGE - Recombinant Human TBC1D22B protein (AB202146)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human TBC1D22B protein (AB202146)

3ug by SDS-PAGE under reducing conditions and visualized by coomassie blue stain.

Key facts

Purity

>85% SDS-PAGE

Expression system

Escherichia coli

Tags

His tag N-Terminus

Applications

SDS-PAGE

applications

Biologically active

No

Accession

Q9NU19

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 7.4 Constituents: 69% PBS, 30% Glycerol (glycerin, glycerine), 0.02% (R*,R*)-1,4-Dimercaptobutan-2,3-diol

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MGSSHHHHHHSSGLVPRGSHMGSMAAENSKQFWKRSAKLPGSIQPVYGAQHPPLDPRLTKNFIKERSKVNTVPLKNKKASSFHEFARNTSDAWDIGDDEEEDFSSPSFQTLNSKVALATAAQVLENHSKLRVKPERSQSTTSDVPANYKVIKSSSDAQLSRNSSDTCLRNPLHKQQSLPLRPIIPLVARISDQNASGAPPMTVREKTRLEKFRQLLSSQNTDLDELRKCSWPGVPREVRPITWRLLSGYLPANTERRKLTLQRKREEYFGFIEQYYDSRNEEHHQDTYRQIHIDIPRTNPLIPLFQQPLVQEIFERILFIWAIRHPASGYVQGINDLVTPFFVVFLSEYVEEDVENFDVTNLSQDMLRSIEADSFWCMSKLLDGIQDNYTFAQPGIQKKVKALEELVSRIDEQVHNHFRRYEVEYLQFAFRWMNNLLMRELPLRCTIRLWDTYQSEPEGFSHFHLYVCAAFLIKWRKEILDEEDFQGLLMLLQNLPTIHWGNEEIGLLLAEAYRLKYMFADAPNHYRR","proteinLength":"Full Length","predictedMolecularWeight":"61.5 kDa","actualMolecularWeight":null,"aminoAcidEnd":505,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q9NU19","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

TBC1D22B also known as TBC (Tre-2/Bub2/Cdc16) domain family member 22B is a protein involved in the regulation of intracellular trafficking and acts as a GTPase-activating protein (GAP) for Rab GTPases. It has a molecular mass of approximately 59 kDa. This protein is expressed in various tissues including the brain liver and kidney. It interacts with intracellular membranes and cytosolic components to modulate the dynamics of vesicular transport processes.
Biological function summary

TBC1D22B modulates cellular functions by influencing the activity of Rab GTPases known regulators of vesicle movement and membrane trafficking. It often forms part of complexes with other proteins to exert its effect on membrane trafficking. This action is essential for maintaining proper cellular organization and homeostasis impacting processes such as endocytosis and exocytosis.

Pathways

TBC1D22B is involved in the Rab-mediated endocytic recycling pathway. Here it acts alongside proteins like Rab11 and Rab4 to regulate the sorting and recycling of vesicles. The protein also plays a role in the regulation of the mTOR signaling pathway which is important for cell growth and metabolism. Through these pathways TBC1D22B influences cellular energy status and nutrient sensing.

Mutations or dysregulation of TBC1D22B have been linked to neurodevelopmental disorders such as autism spectrum disorder and may impact brain function by disrupting Rab pathways. Furthermore its involvement in vesicular pathways connects it to diabetes where improper insulin receptor trafficking occurs. TBC1D22B is related to proteins like Rab7 and Rab14 which have been implicated in insulin signaling and glucose metabolism affecting these conditions.
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Specifications

Form

Liquid

Additional notes

ab202146 was purified by conventional chromatography techniques.

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General info

Function

May act as a GTPase-activating protein for Rab family protein(s).

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Product protocols

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Target data

May act as a GTPase-activating protein for Rab family protein(s).
See full target information TBC1D22B
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