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AB139795

Recombinant Human TBCEL protein

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Recombinant Human TBCEL protein is a Human Full Length protein, in the 1 to 424 aa range, expressed in Escherichia coli, with >95%, suitable for SDS-PAGE, Mass Spec.

View Alternative Names

LRRC35, TBCEL, Tubulin-specific chaperone cofactor E-like protein, EL, Leucine-rich repeat-containing protein 35

1 Images
SDS-PAGE - Recombinant Human TBCEL protein (AB139795)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human TBCEL protein (AB139795)

15% SDS-PAGE analysis of ab139795 (3μg).

Key facts

Purity

>95% SDS-PAGE

Expression system

Escherichia coli

Tags

His tag N-Terminus

Applications

SDS-PAGE, Mass Spec

applications

Biologically active

No

Accession

Q5QJ74

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 20% Glycerol (glycerin, glycerine), 0.88% Sodium chloride, 0.32% Tris HCl, 0.02% (R*,R*)-1,4-Dimercaptobutan-2,3-diol

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "Mass Spec": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MGSSHHHHHHSSGLVPRGSHMGSMDQPSGRSFMQVLCEKYSPENFPYRRGPGMGVHVPATPQGSPMKDRLNLPSVLVLNSCGITCAGDEKEIAAFCAHVSELDLSDNKLEDWHEVSKIVSNVPQLEFLNLSSNPLNLSVLERTCAGSFSGVRKLVLNNSKASWETVHMILQELPDLEELFLCLNDYETVSCPSICCHSLKLLHITDNNLQDWTEIRKLGVMFPSLDTLVLANNHLNAIEEPDDSLARLFPNLRSISLHKSGLQSWEDIDKLNSFPKLEEVRLLGIPLLQPYTTEERRKLVIARLPSVSKLNGSVVTDGEREDSERFFIRYYVDVPQEEVPFRYHELITKYGKLEPLAEVDLRPQSSAKVEVHFNDQVEEMSIRLDQTVAELKKQLKTLVQLPTSNMLLYYFDHEAPFGPEEMKYSSRALHSFGIRDGDKIYVESKTK","proteinLength":"Full Length","predictedMolecularWeight":"50.6 kDa","actualMolecularWeight":null,"aminoAcidEnd":424,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q5QJ74","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

TBCEL also known as Tubulin-folding cofactor E-like is a protein involved in tubulin dynamics. This protein has a mass of approximately 60 kDa and plays a role in the post-translational regulation of tubulin. TBCEL is expressed mainly in neuronal tissues where it influences the stability and disassembly of microtubules by targeting polyglutamylated tubulins. Through its action TBCEL regulates the cytoskeleton impacting cellular shape and organization.
Biological function summary

TBCEL participates in the regulation of microtubule networks important for cell division and intracellular transport. By controlling tubulin degradation TBCEL helps maintain proper microtubule levels within cells. Although not a member of a large complex TBCEL interacts with other microtubule-associated proteins (MAPs) to facilitate the dynamic reorganization of the cytoskeleton important for cell movement and signaling.

Pathways

TBCEL contributes to the ubiquitin-proteasome pathway and the regulation of cytoskeletal arrangements. In these pathways it interacts with proteins such as tubulin-folding cofactors and ubiquitin ligases. Through its modulatory role TBCEL affects microtubule stability and turnover linking it to cellular processes like mitosis and intracellular trafficking. By influencing these pathways TBCEL also indirectly affects protein transport and signal transduction.

TBCEL has associations with neurodegenerative conditions and certain types of cancer. Disrupted TBCEL function can lead to abnormal microtubule stabilization contributing to diseases like Alzheimer's where tau proteins are also implicated. Additionally alterations in TBCEL activity may relate to cancer progression with interactions involving proteins such as p53 highlighting its role in maintaining cellular integrity. Understanding TBCEL's functions can provide insights into targeting these disorders with therapeutic strategies.
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Specifications

Form

Liquid

Additional notes

ab139795 is purified using conventional chromatography techniques.

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General info

Function

Acts as a regulator of tubulin stability.

Subcellular localisation

Cytoskeleton

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Acts as a regulator of tubulin stability.
See full target information TBCEL
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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions
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Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

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