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AB153511

Recombinant Human TBLR1/TBL1XR1 protein (GST tag N-Terminus)

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Recombinant Human TBLR1/TBL1XR1 protein (GST tag N-Terminus) is a Human Full Length protein, in the 1 to 102 aa range, expressed in Wheat germ, suitable for ELISA, WB.

View Alternative Names

IRA1, TBLR1, TBL1XR1, F-box-like/WD repeat-containing protein TBL1XR1, Nuclear receptor corepressor/HDAC3 complex subunit TBLR1, TBL1-related protein 1, Transducin beta-like 1X-related protein 1

1 Images
SDS-PAGE - Recombinant Human TBLR1/TBL1XR1 protein (GST tag N-Terminus) (AB153511)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human TBLR1/TBL1XR1 protein (GST tag N-Terminus) (AB153511)

ab153511 on a 12.5% SDS-PAGE stained with Coomassie Blue.

Key facts

Expression system

Wheat germ

Tags

GST tag N-Terminus

Applications

WB, ELISA

applications

Biologically active

No

Accession

Q9BZK7

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 0.79% Tris HCl, 0.31% Glutathione

storage-buffer

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Complementary Products

Primary Antibodies

AB190796

Anti-TBLR1/TBL1XR1+TBL1X+TBL1Y antibody [EPR16153]

RabMAb|Recombinant

Immunocytochemistry/ Immunofluorescence - Anti-TBLR1/TBL1XR1+TBL1X+TBL1Y antibody [EPR16153] (AB190796)

  • 0
  • 0
Primary Antibodies

AB28179

Anti-TFIIF antibody

ChIP - Anti-TFIIF antibody (AB28179)

  • 5
  • 2
Proteins & Peptides

AB180348

Recombinant Human GDI2 protein (His tag N-Terminus)

SDS-PAGE - Recombinant Human GDI2 protein (His tag N-Terminus) (AB180348)

  • 0
  • 0
Proteins & Peptides

AB85296

Recombinant human RSK4 protein (Active)

Functional Studies - Recombinant human RSK4 protein (Active) (AB85296)

  • 0
  • 0
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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Product details

This product was previously labelled as TBLR1.
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Sequence info

[{"sequence":"MQRYNFHYLKYIVHFYRTCDYSRMIRMVLAYGELLLLTVSAEILFQWTNIVAWQQMPTFCGIAANLQETLVGFSFCFLCFFPLLLNQQGWKEGREVMNYSFQ","proteinLength":"Full Length","predictedMolecularWeight":null,"actualMolecularWeight":null,"aminoAcidEnd":102,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Wheat germ","accessionNumber":"Q9BZK7","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Dry Ice
Appropriate short-term storage conditions
-80°C
Appropriate long-term storage conditions
-80°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

TBLR1 also known as TBL1XR1 is a protein that plays an important role in transcription regulation mechanisms. This protein with a molecular mass of approximately 64 kDa is expressed in various tissues including the brain and lungs. It functions as an adaptor protein facilitating interactions between different transcription factors and the corepressor complex. By doing so it enables the repression or activation of specific genes according to cellular needs.
Biological function summary

TBLR1 participates in the regulation of gene expression by being part of the SMRT/N-CoR repressor complex. This complex interacts with nuclear receptors to modulate gene transcription. Through this function TBLR1 contributes to processes involved in maintaining cellular homeostasis. Its role in this complex marks it as a contributor to the fine-tuning of cellular responses to external stimuli which is essential for normal cellular function.

Pathways

The regulation of transcription by TBLR1 integrates into significant signaling pathways like Wnt and nuclear receptor pathways. It partners with proteins such as beta-catenin in the Wnt signaling pathway and corepressors in the nuclear receptor pathway. Through these partnerships TBLR1 affects important developmental and metabolic processes linking transcriptional machinery to broader regulatory networks in the cell.

TBLR1 has associations with conditions such as cancer and autism spectrum disorder. Mutations or dysregulation in the TBLR1 gene can affect normal cellular signaling leading to aberrant cell growth in cancers or disrupted neural development in autism. Additionally it is connected to the action of the protein N-CoR which is also implicated in these diseases. Through these associations TBLR1 becomes a target of interest for understanding and potentially treating these disorders.
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Specifications

Form

Liquid

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General info

Function

F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units. Plays an essential role in transcription activation mediated by nuclear receptors. Probably acts as integral component of the N-Cor corepressor complex that mediates the recruitment of the 19S proteasome complex, leading to the subsequent proteasomal degradation of N-Cor complex, thereby allowing cofactor exchange, and transcription activation.

Sequence similarities

Belongs to the WD repeat EBI family.

Subcellular localisation

Nucleus

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Product protocols

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Target data

F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units. Plays an essential role in transcription activation mediated by nuclear receptors. Probably acts as integral component of the N-Cor corepressor complex that mediates the recruitment of the 19S proteasome complex, leading to the subsequent proteasomal degradation of N-Cor complex, thereby allowing cofactor exchange, and transcription activation.
See full target information TBL1XR1
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Product promise

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