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AB139211

Recombinant Human TBP like protein TLP

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Recombinant Human TBP like protein TLP is a Human Full Length protein, in the 1 to 186 aa range, expressed in Escherichia coli, with >90%, suitable for SDS-PAGE, Mass Spec.

View Alternative Names

TLF, TLP, TLP21, TRF2, TRP, TBPL1, TATA box-binding protein-like 1, TBP-like 1, 21 kDa TBP-like protein, Second TBP of unique DNA protein, TATA box-binding protein-related factor 2, TBP-like factor, TBP-related protein, STUD, TBP-related factor 2

1 Images
SDS-PAGE - Recombinant Human TBP like protein TLP (AB139211)
  • SDS-PAGE

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SDS-PAGE - Recombinant Human TBP like protein TLP (AB139211)

15% SDS-PAGE analysis of ab139211 (3μg)

Key facts

Purity

>90% SDS-PAGE

Expression system

Escherichia coli

Tags

His tag N-Terminus

Applications

SDS-PAGE, Mass Spec

applications

Biologically active

No

Accession

P62380

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 50% Glycerol (glycerin, glycerine), 1.17% Sodium chloride, 0.32% Tris HCl, 0.03% (R*,R*)-1,4-Dimercaptobutan-2,3-diol, 0.03% EDTA

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "Mass Spec": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MGSSHHHHHHSSGLVPRGSHMGSMDADSDVALDILITNVVCVFRTRCHLNLRKIALEGANVIYKRDVGKVLMKLRKPRITATIWSSGKIICTGATSEEEAKFGARRLARSLQKLGFQVIFTDFKVVNVLAVCNMPFEIRLPEFTKNNRPHASYEPELHPAVCYRIKSLRATLQIFSTGSITVTGPNVKAVATAVEQIYPFVFESRKEIL","proteinLength":"Full Length","predictedMolecularWeight":"23.3 kDa","actualMolecularWeight":null,"aminoAcidEnd":186,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"P62380","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

TBP-like protein TLP also known as TBPL1 is a member of the TATA-binding protein family and has a mass of approximately 31 kDa. TLP is expressed in various tissues throughout the body with notable expression in testis liver and muscle. It functions by binding to the TATA box of DNA a critical component of gene promoters and participates in forming the transcription pre-initiation complex required for RNA polymerase II-mediated transcription.
Biological function summary

TBP-like protein TLP plays a role in the regulation of transcription by serving as part of a multiprotein complex that impacts gene expression. It interacts with other transcription factors to modulate the initiation of transcription of specific genes. TLP can bind distinct promoter sequences allowing for regulatory flexibility in gene expression aiding in developmental and differentiation processes across different tissues.

Pathways

TBP-like protein TLP integrates into transcriptional regulation pathways particularly in the assembly of the transcription pre-initiation complex. This protein collaborates with other proteins like TBP and TFIIA in the transcription machinery. It also participates in chromatin remodeling pathways facilitating changes in DNA accessibility necessary for transcriptional regulation. TLP's ability to engage with these pathways highlights its role in genetic regulatory networks.

TBP-like protein TLP has connections to particular conditions such as testicular germ cell tumors and specific forms of liver disease. Its interaction with TBP is significant as alterations in these transcriptional regulators can impact gene expression patterns linked to tumorigenesis and liver pathology. Understanding TLP's role in these diseases could open up new therapeutic approaches by targeting its activity or interactions within affected tissues.
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Specifications

Form

Liquid

Additional notes

ab139211 was purified using conventional chromatography techniques.

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General info

Function

Part of a specialized transcription system that mediates the transcription of most ribosomal proteins through the 5'-TCT-3' motif which is a core promoter element at these genes. Seems to also mediate the transcription of NF1. Does not bind the TATA box.

Sequence similarities

Belongs to the TBP family.

Subcellular localisation

Nucleus

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Product protocols

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Target data

Part of a specialized transcription system that mediates the transcription of most ribosomal proteins through the 5'-TCT-3' motif which is a core promoter element at these genes. Seems to also mediate the transcription of NF1. Does not bind the TATA box.
See full target information TBPL1
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