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AB132734

Recombinant Human TBRG4 protein (GST tag N-Terminus)

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Recombinant Human TBRG4 protein (GST tag N-Terminus) is a Human Full Length protein, in the 1 to 631 aa range, expressed in Wheat germ, suitable for SDS-PAGE, ELISA, WB.

View Alternative Names

CPR2, FASTKD4, KIAA0948, TBRG4, FAST kinase domain-containing protein 4, Cell cycle progression restoration protein 2, Protein TBRG4, Transforming growth factor beta regulator 4, Cell cycle progression protein 2

1 Images
SDS-PAGE - Recombinant Human TBRG4 protein (GST tag N-Terminus) (AB132734)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human TBRG4 protein (GST tag N-Terminus) (AB132734)

12.5% SDS-PAGE analysis of ab132734 stained with Coomassie Blue.

Key facts

Expression system

Wheat germ

Tags

GST tag N-Terminus

Applications

SDS-PAGE, WB, ELISA

applications

Biologically active

No

Accession

Q969Z0

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 0.79% Tris HCl, 0.31% Glutathione

storage-buffer

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Complementary Products

Primary Antibodies

AB99317

Anti-TBRG4 antibody

Immunoprecipitation - Anti-TBRG4 antibody (AB99317)

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Cell Lines & Lysates

AB266644

Human TBRG4 knockout HEK-293T cell line

Sanger Sequencing - Human TBRG4 knockout HEK-293T cell line (AB266644)

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Cell Lines & Lysates

AB263381

Human TBRG4 knockout HEK-293T cell lysate

Sanger Sequencing - Human TBRG4 knockout HEK-293T cell lysate (AB263381)

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MAAHLVKRCTCLLREAARQAPAMAPVGRLRLAWVAHKTLTSSATSPISHLPGSLMEPVEKERASTPYIEKQVDHLIKKATRPEELLELLGGSHDLDSNQAAMVLIRLSHLLSEKPEDKGLLIQDAHFHQLLCLLNSQIASVWHGTLSKLLGSLYALGIPKASKELQSVEQEVRWRMRKLKYKHLAFLAESCATLSQEQHSQELLAELLTHLERRWTEIEDSHTLVTVMMKVGHLSEPLMNRLEDKCLELVEHFGPNELRKVLVMLAAQSRRSVPLLRAISYHLVQKPFSLTKDVLLDVAYAYGKLSFHQTQVSQRLATDLLSLMPSLTSGEVAHCAKSFALLKWLSLPLFEAFAQHVLNRAQDITLPHLCSVLLAFARLNFHPDQEDQFFSLVHEKLGSELPGLEPALQVDLVWALCVLQQAREAELQAVLHPEFHIQFLGGKSQKDQNTFQKLLHINATALLEYPEYSGPLLPASAVAPGPSALDRKVTPLQKELQETLKGLLGSADKGSLEVATQYGWVLDAEVLLDSDGEFLPVRDFVAPHLAQPTGSQSPPPGSKRLAFLRWEFPNFNSRSKDLLGRFVLARRHIVAAGFLIVDVPFYEWLELKSEWQKGAYLKDKMRKAVAEELAK","proteinLength":"Full Length","predictedMolecularWeight":"97.1 kDa","actualMolecularWeight":null,"aminoAcidEnd":631,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Wheat germ","accessionNumber":"Q969Z0","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Dry Ice
Appropriate short-term storage conditions
-80°C
Appropriate long-term storage conditions
-80°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

TBRG4 also known as FAM195A or BRG1-Associated Factor-53A is a protein with a molecular mass of approximately 144 kDa. It participates in the regulation of cellular homeostasis and function by interacting with other proteins in the cell. Expression of TBRG4 is not limited to a specific tissue as it can be detected in multiple tissues across the body including brain and immune cells. Due to its versatile expression TBRG4 likely takes part in general cellular mechanisms across different cell types.
Biological function summary

TBRG4 influences several cellular processes through its involvement in protein interactions. It is an integral part of large molecular complexes that regulate various gene expression and remodeling of chromatin. TBRG4 often functions in concert with other components to ensure accurate modulation of transcriptional activity. Complex formation affects both direct regulation of target genes and the structural rearrangements necessary for cellular homeostasis.

Pathways

The protein plays a role in the cellular response to stress and metabolic signaling. It acts within the mTOR signaling pathway which is central to the regulation of growth and metabolism. TBRG4 interacts with other proteins like Raptor and mLST8 to modulate mTOR complex functions. Additionally it is related to the PKC signaling pathway where it may indirectly influence cellular responses to external stimuli through modulation of other participating proteins.

TBRG4 connects to both cancer and neurodegenerative diseases due to its role in cell growth and stress response. Abnormal expression or malfunction of TBRG4 may contribute to the progression of certain cancers reflecting its interaction with proteins like p53 in tumor suppression pathways. In neurodegenerative conditions alterations in TBRG4-related pathways might exacerbate pathological features particularly through dysregulated signaling mechanisms involving proteins such as Tau.
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Specifications

Form

Liquid

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General info

Function

Plays a role in processing of mitochondrial RNA precursors and in stabilization of a subset of mature mitochondrial RNA species, such as MT-CO1, MT-CO2, MT-CYB, MT-CO3, MT-ND3, MT-ND5 and MT-ATP8/6. May play a role in cell cycle progression (PubMed : 9383053).

Sequence similarities

Belongs to the FAST kinase family.

Subcellular localisation

Mitochondrion matrix

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Product protocols

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Target data

Plays a role in processing of mitochondrial RNA precursors and in stabilization of a subset of mature mitochondrial RNA species, such as MT-CO1, MT-CO2, MT-CYB, MT-CO3, MT-ND3, MT-ND5 and MT-ATP8/6. May play a role in cell cycle progression (PubMed : 9383053).
See full target information TBRG4
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