Recombinant Human TC-2 protein (His tag) is a Human Full Length protein, in the 1 to 427 aa range, expressed in HEK 293, with >90% purity, < 1 EU/µg endotoxin level and suitable for SDS-PAGE.
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Key facts
- Purity
- >90% SDS-PAGE
- Endotoxin level
- < 1 EU/µg
- Expression system
- HEK 293 cells
- Tags
- His tag C-Terminus
- Applications
- SDS-PAGE
- Biologically active
- No
Amino acid sequence
M R H L G A F L F L L G V L G A L T E M C E I P E M D S H L V E K L G Q H L L P W M D R L S L E H L N P S I Y V G L R L S S L Q A G T K E D L Y L H S L K L G Y Q Q C L L G S A F S E D D G D C Q G K P S M G Q L A L Y L L A L R A N C E F V R G H K G D R L V S Q L K W F L E D E K R A I G H D H K G H P H T S Y Y Q Y G L G I L A L C L H Q K R V H D S V V D K L L Y A V E P F H Q G H H S V D T A A M A G L A F T C L K R S N F N P G R R Q R I T M A I R T V R E E I L K A Q T P E G H F G N V Y S T P L A L Q F L M T S P M R G A E L G T A C L K A R V A L L A S L Q D G A F Q N A L M I S Q L L P V L N H K T Y I D L I F P D C L A P R V M L E P A A E T I P Q T Q E I I S V T L Q V L S L L P P Y R Q S I S V L A G S T V E D V L K K A H E L G G F T Y E T Q A S L S G P Y L T S V M G K A A G E R E F W Q L L R D P N T P L L Q G I A D Y R P K D G E T I E L R L V S W
Reactivity data
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
Target data
Function
Primary vitamin B12-binding and transport protein. Delivers cobalamin to cells.
Alternative names
TC2, TCN2, Transcobalamin-2, TC-2, Transcobalamin II, TC II, TCII
Recommended products
Recombinant Human TC-2 protein (His tag) is a Human Full Length protein, in the 1 to 427 aa range, expressed in HEK 293, with >90% purity, < 1 EU/µg endotoxin level and suitable for SDS-PAGE.
Key facts
- Purity
- >90% SDS-PAGE
- Endotoxin level
- < 1 EU/µg
- Expression system
- HEK 293 cells
- Tags
- His tag C-Terminus
- Applications
- SDS-PAGE
- Biologically active
- No
- Accession
- P20062-1
- Animal free
- No
- Carrier free
- Yes
- Species
- Human
- Concentration
- Storage buffer
pH: 7.4
Constituents: 100% PBS
Sequence info
Amino acid sequence
- M R H L G A F L F L L G V L G A L T E M C E I P E M D S H L V E K L G Q H L L P W M D R L S L E H L N P S I Y V G L R L S S L Q A G T K E D L Y L H S L K L G Y Q Q C L L G S A F S E D D G D C Q G K P S M G Q L A L Y L L A L R A N C E F V R G H K G D R L V S Q L K W F L E D E K R A I G H D H K G H P H T S Y Y Q Y G L G I L A L C L H Q K R V H D S V V D K L L Y A V E P F H Q G H H S V D T A A M A G L A F T C L K R S N F N P G R R Q R I T M A I R T V R E E I L K A Q T P E G H F G N V Y S T P L A L Q F L M T S P M R G A E L G T A C L K A R V A L L A S L Q D G A F Q N A L M I S Q L L P V L N H K T Y I D L I F P D C L A P R V M L E P A A E T I P Q T Q E I I S V T L Q V L S L L P P Y R Q S I S V L A G S T V E D V L K K A H E L G G F T Y E T Q A S L S G P Y L T S V M G K A A G E R E F W Q L L R D P N T P L L Q G I A D Y R P K D G E T I E L R L V S W
- Accession
- P20062
- Protein length
- Full Length
- Predicted molecular weight
- 46.7 kDa
- Amino acids
- 1 to 427
- Nature
- Recombinant
- Tags
- His tag C-Terminus
Specifications
- Form
- Lyophilized
General info
- Function
Primary vitamin B12-binding and transport protein. Delivers cobalamin to cells.
- Sequence similarities
Belongs to the eukaryotic cobalamin transport proteins family.
Storage
- Shipped at conditions
- Ambient - Can Ship with Ice
- Appropriate short-term storage conditions
- -20°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
TC-2 also known as Transcription Complex 2 is a protein with a molecular mass of approximately 45 kDa. It is widely expressed in the nucleus of various cell types especially in tissues with high transcriptional activity such as the liver and brain. As part of the transcription machinery TC-2 interacts with DNA influencing the expression of specific genes critical for cellular function.
- Biological function summary
This protein facilitates the assembly of transcriptional pre-initiation complexes. TC-2 serves as a scaffolding component connecting different transcription factors and RNA polymerase II essential for gene initiation. It operates as part of a larger multi-protein complex which synchronizes the gene transcription process integrating signals that impact gene expression.
- Pathways
TC-2 interacts extensively with gene regulation pathways such as the RNA polymerase II transcription pathway and the nuclear receptor signaling pathway. It is closely related to the protein transcription factor TBP in these pathways coordinating the transcription initiation process. These interactions highlight TC-2's role in the orchestration of gene expression through precise pathway integrations.
- Associated diseases and disorders
Abnormalities in TC-2 expression or function have been linked to certain cancers and neurological disorders. Aberrant expression of TC-2 can affect gene regulation contributing to the development of hepatocellular carcinoma and schizophrenia. It often involves other proteins like the p53 tumor suppressor in cancer progression and neural activity modulators in brain-related diseases.
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1 product image
SDS-PAGE - Recombinant Human TC-2 protein (His tag) (ab276296)
SDS-PAGE analysis of ab276296
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