Recombinant Human TCEAL2 protein (His tag) is a Human Full Length protein, in the 1 to 227 aa range, expressed in Escherichia coli, with >70% purity and suitable for SDS-PAGE, WB, MS.
Images
Key facts
- Purity
- >70% SDS-PAGE
- Expression system
- Escherichia coli
- Tags
- His tag C-Terminus
- Applications
- SDS-PAGE, WB, MS
- Biologically active
- No
Amino acid sequence
M E K L F N E N E G M P S N Q G K I D N E E Q P P H E G K P E V A C I L E D K K L E N E G N T E N T G K R V E E P L K D K E K P E S A G K A K G E G K S E R K G K S E M Q G G S K T E G K P E R G G R A E G E G E P D S E R E P E S E G E P E S E T R A A G K R P A E D D I P R K A K R K T N K G L A Q Y L K Q Y K E A I H D M N F S N E D M I R E F D N M A R V E D K R R K S K Q K L G A F L W M Q R N L Q D P F Y P R G P R E F R G G C R A P R R D T E D I P Y V
Reactivity data
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
Application WB | Reactivity Reacts | Dilution info - | Notes - |
Application MS | Reactivity Reacts | Dilution info - | Notes - |
Target data
Function
May be involved in transcriptional regulation.
Alternative names
My048, MY0876G0, TCEAL2, Transcription elongation factor A protein-like 2, TCEA-like protein 2, Transcription elongation factor S-II protein-like 2
Recommended products
Recombinant Human TCEAL2 protein (His tag) is a Human Full Length protein, in the 1 to 227 aa range, expressed in Escherichia coli, with >70% purity and suitable for SDS-PAGE, WB, MS.
Key facts
- Purity
- >70% SDS-PAGE
- Expression system
- Escherichia coli
- Tags
- His tag C-Terminus
- Applications
- SDS-PAGE, WB, MS
- Biologically active
- No
- Accession
- Q9H3H9-1
- Animal free
- No
- Species
- Human
- Concentration
- Storage buffer
pH: 7.3
Constituents: 0.87% DL-Arginine, 0.87% Sodium chloride, 0.5% Sucrose, 0.24% Sodium dihydrogen phosphate, 0.015% (R*,R*)-1,4-Dimercaptobutan-2,3-diol
Sequence info
Amino acid sequence
- M E K L F N E N E G M P S N Q G K I D N E E Q P P H E G K P E V A C I L E D K K L E N E G N T E N T G K R V E E P L K D K E K P E S A G K A K G E G K S E R K G K S E M Q G G S K T E G K P E R G G R A E G E G E P D S E R E P E S E G E P E S E T R A A G K R P A E D D I P R K A K R K T N K G L A Q Y L K Q Y K E A I H D M N F S N E D M I R E F D N M A R V E D K R R K S K Q K L G A F L W M Q R N L Q D P F Y P R G P R E F R G G C R A P R R D T E D I P Y V
- Accession
- Q9H3H9
- Protein length
- Full Length
- Predicted molecular weight
- 26.67 kDa
- Amino acids
- 1 to 227
- Nature
- Recombinant
- Tags
- His tag C-Terminus
Specifications
- Form
- Liquid
- Additional notes
ab204770 was purified by 6xHis tag / Immobilized-metal affinity chromatography (IMAC).
General info
- Function
May be involved in transcriptional regulation.
- Sequence similarities
Belongs to the TFS-II family. TFA subfamily.
- Subcellular localisation
- Nucleus
Storage
- Shipped at conditions
- Dry Ice
- Appropriate short-term storage duration
- 1-2 weeks
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -80°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
TCEAL2 also known as Transcription Elongation Factor A (SII)-Like 2 is a protein that plays a role in transcriptional regulation. It has a molecular mass of approximately 20 kDa. Researchers have observed TCEAL2 expression in various tissues including the brain and testis but its highest expression seems in certain cancerous tissues. The protein exists predominantly in the nucleus due to its involvement in controlling DNA-related processes.
- Biological function summary
Scientists believe this protein influences the transcriptional elongation phase of gene expression. TCEAL2 belongs to the TCEAL (Transcription Elongation Factor A) family known for their role in modulating transcription efficiency. While TCEAL2 does not appear to be part of a larger complex it might interact with other transcription factors to regulate the expression of specific genes. This regulation function plays an important role in cellular responses to various signaling events.
- Pathways
TCEAL2 has been associated with the transcriptional regulation pathway which influences a wide range of genes. It is potentially linked to the pathway involving cell growth and differentiation though details remain under investigation. The interaction of TCEAL2 with transcription factors like NF-kB implies a role in broader signaling cascades that mediate diverse cellular responses impacting cellular homeostasis and stress response mechanisms.
- Associated diseases and disorders
Scientific studies have explored TCEAL2’s association with certain cancers such as prostate cancer and glioblastoma. Changes in its expression levels may contribute to the progression or suppression of these cancers. Moreover TCEAL2 interacts with tumor suppressor proteins like p53 suggesting its involvement in pathways affecting cellular proliferation and apoptosis ultimately influencing cancer biology. Understanding these interactions can help in developing potential therapeutic interventions.
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2 product images
Western blot - Recombinant Human TCEAL2 protein (His tag) (ab204770)
Western blot analysis of ab204770.
All lanes: Western blot - Recombinant Human TCEAL2 protein (His tag) (ab204770)
SDS-PAGE - Recombinant Human TCEAL2 protein (His tag) (ab204770)
10% SDS-PAGE analysis of ab204770 stained with Coomassie Blue.
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