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AB236331

Recombinant Human TCN1 protein (Tagged)

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(1 Publication)

Recombinant Human TCN1 protein (Tagged) is a Human Full Length protein, in the 24 to 433 aa range, expressed in Escherichia coli, with >90%, suitable for SDS-PAGE.

View Alternative Names

TC1, TCN1, Transcobalamin-1, TC-1, Haptocorrin, Protein R, Transcobalamin I, HC, TC I, TCI

1 Images
SDS-PAGE - Recombinant Human TCN1 protein (Tagged) (AB236331)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human TCN1 protein (Tagged) (AB236331)

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) analysis with 5% enrichment gel and 15% separation gel of ab236331.

Key facts

Purity

>90% SDS-PAGE

Expression system

Escherichia coli

Tags

6x His tag N-Terminus SUMO tag N-Terminus

Applications

SDS-PAGE

applications

Biologically active

No

Accession

P20061

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 7.2 - 7.4 Constituents: Tris buffer, 50% Glycerol (glycerin, glycerine)

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"EICEVSEENYIRLKPLLNTMIQSNYNRGTSAVNVVLSLKLVGIQIQTLMQKMIQQIKYNVKSRLSDVSSGELALIILALGVCRNAEENLIYDYHLIDKLENKFQAEIENMEAHNGTPLTNYYQLSLDVLALCLFNGNYSTAEVVNHFTPENKNYYFGSQFSVDTGAMAVLALTCVKKSLINGQIKADEGSLKNISIYTKSLVEKILSEKKENGLIGNTFSTGEAMQALFVSSDYYNENDWNCQQTLNTVLTEISQGAFSNPNAAAQVLPALMGKTFLDINKDSSCVSASGNFNISADEPITVTPPDSQSYISVNYSVRINETYFTNVTVLNGSVFLSVMEKAQKMNDTIFGFTMEERSWGPYITCIQGLCANNNDRTYWELLSGGEPLSQGAGSYVVRNGENLEVRWSKY","proteinLength":"Full Length","predictedMolecularWeight":"61.6 kDa","actualMolecularWeight":null,"aminoAcidEnd":433,"aminoAcidStart":24,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"P20061","tags":[{"tag":"6x His","terminus":"N-Terminus"},{"tag":"SUMO","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The TCN1 protein also known as transcobalamin I (or haptocorrin) functions as a glycoprotein responsible for binding vitamin B12 (cobalamin) within the body. TCN1 facilitates the protection and transport of vitamin B12 from degradation by gastric acid. The mass of TCN1 is about 50-60 kDa. It is mainly expressed in secretory tissues especially the salivary glands but can also be found in leukocytes and other tissues involved in the synthesis of vitamin B12 binding proteins.
Biological function summary

TCN1 plays an integral role in the storage and metabolism of vitamin B12 acting as a carrier within the circulatory system. While TCN1 itself is not a part of a complex it binds tightly to cobalamin to form a complex essential for the stability and availability of this vitamin. Vitamin B12 is important for DNA synthesis as well as fatty acid and amino acid metabolism highlighting the importance of TCN1 in cellular processes and overall metabolic health.

Pathways

The storage and transport of vitamin B12 involving TCN1 intersect significantly with metabolic pathways such as the one-carbon metabolism. This pathway is intimately connected with DNA synthesis and methylation activities and involves related proteins like methylmalonyl-CoA mutase and methionine synthase. Disruptions in these pathways may potentially affect protein synthesis and cell replication impacting various biological functions.

TCN1 is associated with conditions such as vitamin B12 deficiency and pernicious anemia. Vitamin B12 deficiency can occur due to improper cobalamin transport which TCN1 along with other proteins like intrinsic factor (an important protein in vitamin B12 absorption) helps mitigate. In pernicious anemia autoantibodies may affect intrinsic factor or gastric parietal cells highlighting a link with TCN1-mediated processes potentially disrupted which could impact hematological and neurological health.
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Specifications

Form

Liquid

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General info

Function

Binds vitamin B12 with femtomolar affinity and protects it from the acidic environment of the stomach.

Sequence similarities

Belongs to the eukaryotic cobalamin transport proteins family.

Post-translational modifications

Contains about 30% carbohydrates.

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Product protocols

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Target data

Binds vitamin B12 with femtomolar affinity and protects it from the acidic environment of the stomach.
See full target information TCN1
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Cell reports 43:114863 PubMed39396234

2024

OLFM4 regulates the antimicrobial and DNA binding activity of neutrophil cationic proteins.

Applications

Unspecified application

Species

Unspecified reactive species

Sophie Vandenberghe-Dürr,Michel Gilliet,Jeremy Di Domizio
View all publications
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