Recombinant Human TCTP protein

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

TCTP also known as Translationally Controlled Tumor Protein or histamine-releasing factor (HRF) is a multifunctional protein with a molecular mass of approximately 19 kDa. It is found in a variety of tissues and cell types including cytoplasm and extracellular environments. The protein engages in cellular processes such as cell growth development and apoptosis. TCTP regulates microtubule stability cell cycle progression and protein synthesis reflecting its broad mechanical roles within cells.

Biological function summary

In both animal and human cells TCTP acts as a prosurvival factor by inhibiting apoptosis. It binds with proteins like Bcl-2 and Bax playing a role in the regulation of cell death. Furthermore TCTP appears to mediate immune responses through its histamine-releasing factor activity. It interacts within protein complexes that manage cytoskeletal dynamics and stress responses contributing to cellular adaptability.

Pathways

The protein interacts in critical pathways such as the MAPK signaling pathway and the apoptosis pathway. In the MAPK pathway TCTP modulates cell growth and proliferation by interacting with proteins like ERK1/2. In the apoptosis pathway TCTP's interaction with Bcl-xL and Bax highlights its role in the fine-tuning of cell survival and death processes. These pathways highlight its participation in essential cellular functions and disease progression.

TCTP has implications in cancer and allergy. Altered expression and function of TCTP have been linked to tumor growth and resistance to cancer therapies often regulated through complex interactions with proteins like p53. In allergies its role in histamine release positions it as a mediator in allergic asthma and other hypersensitivity reactions. These associations emphasize the clinical relevance of TCTP and its potential as a therapeutic target.