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AB159663

Recombinant Human TEAD3 protein (GST tag N-Terminus)

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Recombinant Human TEAD3 protein (GST tag N-Terminus) is a Human Full Length protein, in the 1 to 324 aa range, expressed in Wheat germ, suitable for ELISA, WB.

View Alternative Names

TEAD5, TEF5, TEAD3, Transcriptional enhancer factor TEF-5, DTEF-1, TEA domain family member 3, TEAD-3

1 Images
SDS-PAGE - Recombinant Human TEAD3 protein (GST tag N-Terminus) (AB159663)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human TEAD3 protein (GST tag N-Terminus) (AB159663)

ab159663 on a 12.5% SDS-PAGE stained with Coomassie Blue.

Key facts

Expression system

Wheat germ

Tags

GST tag N-Terminus

Applications

WB, ELISA

applications

Biologically active

No

Accession

Q99594

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 0.79% Tris HCl, 0.31% Glutathione

storage-buffer

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Proteins & Peptides

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Recombinant Human TEAD4 protein (His tag)

SDS-PAGE - Recombinant Human TEAD4 protein (His tag) (AB238222)

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Primary Antibodies

AB205270

Anti-active YAP1 antibody [EPR19812]

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Western blot - Anti-active YAP1 antibody [EPR19812] (AB205270)

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Primary Antibodies

AB222512

Anti-Claudin 18.2 antibody [EPR19202]

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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Claudin 18.2 antibody [EPR19202] (AB222512)

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Primary Antibodies

AB52946

Anti-Histone H3 (acetyl K14) antibody [EP964Y] - ChIP Grade

BOND RX™ Validated|RabMAb|Recombinant|Advanced Validation

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Histone H3 (acetyl K14) antibody [EP964Y] - ChIP Grade (AB52946)

  • 5
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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MNLDQVSKDKALQSMASMSSAQIVSASVLQNKFSPPSPLPQAVFSTSSRFWSSPPLLGQQPGPSQDIKPFAQPAYPIQPPLPPTLSSYEPLAPLPSAAASVPVWQDRTIASSRLRLLEYSAFMEVQRDPDTYSKHLFVHIGQTNPAFSDPPLEAVDVRQIYDKFPEKKGGLKELYEKGPPNAFFLVKFWADLNSTIQEGPGAFYGVSSQYSSADSMTISVSTKVCSFGKQVVEKVETEYARLENGRFVYRIHRSPMCEYMINFIHKLKHLPEKYMMNSVLENFTILQVVTSRDSQETLLVIAFVFEVSTSEHGAQHHVYKLVKD","proteinLength":"Full Length","predictedMolecularWeight":null,"actualMolecularWeight":null,"aminoAcidEnd":324,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Wheat germ","accessionNumber":"Q99594","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Dry Ice
Appropriate short-term storage conditions
-80°C
Appropriate long-term storage conditions
-80°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

TEAD3 also known as TEF-5 is a transcription factor that plays an important role in regulating gene expression. It belongs to the TEA/ATTS domain family and has a molecular mass of around 47 kDa. This protein is expressed in several tissues including the heart liver and skeletal muscle suggesting its involvement in various cellular functions across different organ systems. The mechanical action of TEAD3 involves binding to DNA sequences within the nucleus to modulate transcription of target genes.
Biological function summary

TEA/ATTS domain family members like TEAD3 activate transcription of genes involved in proliferation and differentiation. TEAD3 partners with co-factors such as YAP (Yes-associated protein) to form a complex that influences gene expression patterns critical for cellular growth and development. The interactions between TEAD3 and its co-factors play a significant role in mediating pathways that sustain normal tissue function and adaptation.

Pathways

Numerous cellular functions hinge on the YAP-TEAD3 interaction a focal point of the Hippo signaling pathway which governs cell growth apoptosis and the stem cell population. In addition TEAD3 features in the Wnt signaling pathway thereby affecting processes of embryogenesis and tissue regeneration. Through these pathways TEAD3 connects with other proteins like TAZ (transcriptional coactivator with PDZ-binding motif) and β-catenin to mediate signal transduction and cellular response.

TEAD3's deregulation links to various cancers and fibrotic diseases. Aberrant activity in the Hippo pathway involving TEAD3 and YAP has been observed in hepatocellular carcinoma contributing to unchecked cellular proliferation and survival. Similarly in renal fibrosis altered TEAD3 activity impacts the expression of fibrotic markers often observed with changes in the TGF-β (transforming growth factor-beta) signaling pathway. Understanding these relationships can offer insights into developing therapeutic strategies targeting TEAD3 interactions in disease contexts.
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Specifications

Form

Liquid

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General info

Function

Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds to multiple functional elements of the human chorionic somatomammotropin-B gene enhancer.

Subcellular localisation

Nucleus

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Product protocols

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Target data

Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds to multiple functional elements of the human chorionic somatomammotropin-B gene enhancer.
See full target information TEAD3
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Product promise

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