JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB276695

Recombinant Human TECTB protein (His tag)

Be the first to review this product! Submit a review

|

(0 Publication)

Recombinant Human TECTB protein (His tag) is a Human Fragment protein, in the 1 to 304 aa range, expressed in HEK 293 cells, with >95%, < 1 EU/µg endotoxin level, suitable for SDS-PAGE.

View Alternative Names

Beta-tectorin, TECTB

1 Images
SDS-PAGE - Recombinant Human TECTB protein (His tag) (AB276695)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human TECTB protein (His tag) (AB276695)

SDS-PAGE analysis of ab276695

Key facts

Purity

>95% SDS-PAGE

Endotoxin level

< 1 EU/µg

Expression system

HEK 293 cells

Tags

His tag C-Terminus

Applications

SDS-PAGE

applications

Biologically active

No

Accession

Q96PL2

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 7.4 Constituents: PBS

storage-buffer

style
left-column

Complementary Products

Proteins & Peptides

AB183259

Recombinant Human TSR2 protein (His tag N-Terminus)

SDS-PAGE - Recombinant Human TSR2 protein (His tag N-Terminus) (AB183259)

  • 0
  • 0
Proteins & Peptides

AB181920

Recombinant Human TRBP protein (denatured) (Tag Free)

SDS-PAGE - Recombinant Human TRBP protein (denatured) (Tag Free) (AB181920)

  • 0
  • 0
Proteins & Peptides

AB181931

Recombinant Human THAP7 protein (denatured) (His tag N-Terminus)

SDS-PAGE - Recombinant Human THAP7 protein (denatured) (His tag N-Terminus) (AB181931)

  • 0
  • 0
Proteins & Peptides

AB181934

Recombinant Human ZNF32 protein (denatured) (His tag N-Terminus)

SDS-PAGE - Recombinant Human ZNF32 protein (denatured) (His tag N-Terminus) (AB181934)

  • 0
  • 0
style
left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
style
left-column
style
left-column

Sequence info

[{"linker":null,"sequence":"MVTKAFVLLAIFAEASAKSCAPNKADVILVFCYPKTIITKIPECPYGWEVHQLALGGLCYNGVHEGGYYQFVIPDLSPKNKSYCGTQSEYKPPIYHFYSHIVSNDTTVIVKNQPVNYSFSCTYHSTYLVNQAAFDQRVATVHVKNGSMGTFESQLSLNFYTNAKFSIKKEAPFVLEASEIGSDLFAGVEAKGLSIRFKVVLNSCWATPSADFMYPLQWQLINKGCPTDETVLVHENGRDHRATFQFNAFRFQNIPKLSKVWLHCETFICDSEKLSCPVTCDKRKRLLRDQTGGVLVVELSLRSR","proteinLength":"Fragment","predictedMolecularWeight":"33.9 kDa","actualMolecularWeight":null,"aminoAcidEnd":304,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"HEK 293 cells","accessionNumber":"Q96PL2","tags":[{"tag":"His","terminus":"C-Terminus"}]}]
style
left-column

Properties and storage information

Form
Lyophilized
Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
style
left-column

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

TECTB also known as tectorin beta is a protein with a mass of approximately 63.5 kDa. It plays a structural role in the inner ear particularly within the tectorial membrane which is an important component of the cochlea. TECTB is expressed primarily in the cochlear hair cells. This protein contributes to the mechanical properties of the tectorial membrane by forming a network with other associated proteins enabling sound-induced vibration detection.
Biological function summary

The tectorial membrane's function depends on the structural integrity provided by TECTB. It is part of a complex that includes alpha tectorin (TECTA) and other non-collagenous components. Together these proteins form an intricate matrix that maintains the membrane's mechanical properties essential for proper auditory transduction. The complex's ability to transmit sound energy effectively depends on the arrangement of its protein components which TECTB helps stabilize.

Pathways

TECTB plays a role in the mechanotransduction pathway within the auditory system. This pathway involves the conversion of mechanical stimuli into neural signals a process closely associated with proteins such as prestin and myosin VIIA. TECTB's interaction with these proteins ensures the efficient transmission of sound-induced oscillations to the sensory hair cells contributing to hearing function.

Mutations or malfunctions in TECTB can lead to hearing impairment specifically non-syndromic hearing loss. Defects in the TECTB-related tectorial membrane complex may affect sound wave transmission and result in auditory pathology. TECTA another protein within the complex also associates with similar hearing disorders. These connections highlight TECTB's critical role in auditory health and the potential consequences when its function is compromised.
style
left-column

General info

Function

One of the major non-collagenous components of the tectorial membrane (By similarity). The tectorial membrane is an extracellular matrix of the inner ear that covers the neuroepithelium of the cochlea and contacts the stereocilia bundles of specialized sensory hair cells. Sound induces movement of these hair cells relative to the tectorial membrane, deflects the stereocilia and leads to fluctuations in hair-cell membrane potential, transducing sound into electrical signals.

Post-translational modifications

The presence of a hydrophobic C-terminus preceded by a potential cleavage site strongly suggests that tectorins are synthesized as glycosylphosphatidylinositol-linked, membrane-bound precursors. Tectorins are targeted to the apical surface of the inner ear epithelia by the lipid and proteolytically released into the extracellular compartment.

style
left-column

Product protocols

style
left-column

Target data

One of the major non-collagenous components of the tectorial membrane (By similarity). The tectorial membrane is an extracellular matrix of the inner ear that covers the neuroepithelium of the cochlea and contacts the stereocilia bundles of specialized sensory hair cells. Sound induces movement of these hair cells relative to the tectorial membrane, deflects the stereocilia and leads to fluctuations in hair-cell membrane potential, transducing sound into electrical signals.
See full target information TECTB
style
left-column
style
left-column
style
right-column

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com