Recombinant Human Tetranectin protein (His tag) is a Human Full Length protein, in the 1 to 202 aa range, expressed in HEK 293, with >90% purity, < 1 EU/µg endotoxin level and suitable for SDS-PAGE.
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Key facts
- Purity
- >90% SDS-PAGE
- Endotoxin level
- < 1 EU/µg
- Expression system
- HEK 293 cells
- Tags
- His tag C-Terminus
- Applications
- SDS-PAGE
- Biologically active
- No
Amino acid sequence
M E L W G A Y L L L C L F S L L T Q V T T E P P T Q K P K K I V N A K K D V V N T K M F E E L K S R L D T L A Q E V A L L K E Q Q A L Q T V C L K G T K V H M K C F L A F T Q T K T F H E A S E D C I S R G G T L G T P Q T G S E N D A L Y E Y L R Q S V G N E A E I W L G L N D M A A E G T W V D M T G A R I A Y K N W E T E I T A Q P D G G K T E N C A V L S G A A N G K W F D K R C R D Q L P Y I C Q F G I V
Reactivity data
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
Target data
Function
Tetranectin binds to plasminogen and to isolated kringle 4. May be involved in the packaging of molecules destined for exocytosis. Plays a role in retinal function (PubMed:35331648).
Alternative names
TNA, CLEC3B, Tetranectin, TN, C-type lectin domain family 3 member B, Plasminogen kringle 4-binding protein
Recommended products
Recombinant Human Tetranectin protein (His tag) is a Human Full Length protein, in the 1 to 202 aa range, expressed in HEK 293, with >90% purity, < 1 EU/µg endotoxin level and suitable for SDS-PAGE.
Key facts
- Purity
- >90% SDS-PAGE
- Endotoxin level
- < 1 EU/µg
- Expression system
- HEK 293 cells
- Tags
- His tag C-Terminus
- Applications
- SDS-PAGE
- Biologically active
- No
- Accession
- P05452-1
- Animal free
- No
- Species
- Human
- Concentration
- Storage buffer
pH: 7.4
Constituents: 100% PBS
Sequence info
Amino acid sequence
- M E L W G A Y L L L C L F S L L T Q V T T E P P T Q K P K K I V N A K K D V V N T K M F E E L K S R L D T L A Q E V A L L K E Q Q A L Q T V C L K G T K V H M K C F L A F T Q T K T F H E A S E D C I S R G G T L G T P Q T G S E N D A L Y E Y L R Q S V G N E A E I W L G L N D M A A E G T W V D M T G A R I A Y K N W E T E I T A Q P D G G K T E N C A V L S G A A N G K W F D K R C R D Q L P Y I C Q F G I V
- Accession
- P05452
- Protein length
- Full Length
- Predicted molecular weight
- 21.5 kDa
- Amino acids
- 1 to 202
- Nature
- Recombinant
- Tags
- His tag C-Terminus
Specifications
- Form
- Lyophilized
General info
- Function
Tetranectin binds to plasminogen and to isolated kringle 4. May be involved in the packaging of molecules destined for exocytosis. Plays a role in retinal function (PubMed:35331648).
Storage
- Shipped at conditions
- Ambient - Can Ship with Ice
- Appropriate short-term storage conditions
- -20°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
Tetranectin also known as C-type lectin domain family 3 member B (CLEC3B) is a glycoprotein with a molecular mass of about 20 kDa. It primarily exists in the bloodstream where it acts in various physiological processes. This protein expresses itself in other tissues such as liver and lungs suggesting a broad functional role across different biological systems. Its intuitive structure and function mark it for various protein-protein interactions.
- Biological function summary
Tetranectin binds specifically to plasminogen a proenzyme which plays a role in breaking down fibrin in blood clots. It is known to be a part of the fibrinolytic system where it aids in tissue remodeling and repair by promoting the activation of plasminogen to plasmin. These activities suggest an integral role in maintaining vascular health and tissue dynamics. Moreover its involvement in these processes highlights the multifunctional attributes of this protein within human biology.
- Pathways
Tetranectin is a component within coagulation and fibrinolytic pathways. Its interaction with plasminogen highlights its importance in the conversion pathway of plasminogen to plasmin which is essential in dissolving fibrin clots. Additionally Tetranectin’s contributions in the extracellular matrix further connect it with other proteins such as fibronectin and vitronectin facilitating cellular infrastructure and wound healing.
- Associated diseases and disorders
Researchers have linked alterations in Tetranectin levels with various conditions particularly cancer and osteoporosis. In cancer it associates with tumor growth and metastasis due to its role in tissue remodeling and plasminogen activation. In osteoporosis diminished levels of Tetranectin correlate with impaired bone density and integrative functions. Its interaction with plasminogen within these diseases illustrates not only its importance in fibrinolytic pathways but also its potential as a biomarker for pathological conditions.
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1 product image
SDS-PAGE - Recombinant Human Tetranectin protein (His tag) (ab276491)
SDS-PAGE analysis of ab276491
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