Recombinant Human Tetranectin protein (His tag)

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Tetranectin also known as C-type lectin domain family 3 member B (CLEC3B) is a glycoprotein with a molecular mass of about 20 kDa. It primarily exists in the bloodstream where it acts in various physiological processes. This protein expresses itself in other tissues such as liver and lungs suggesting a broad functional role across different biological systems. Its intuitive structure and function mark it for various protein-protein interactions.

Biological function summary

Tetranectin binds specifically to plasminogen a proenzyme which plays a role in breaking down fibrin in blood clots. It is known to be a part of the fibrinolytic system where it aids in tissue remodeling and repair by promoting the activation of plasminogen to plasmin. These activities suggest an integral role in maintaining vascular health and tissue dynamics. Moreover its involvement in these processes highlights the multifunctional attributes of this protein within human biology.

Pathways

Tetranectin is a component within coagulation and fibrinolytic pathways. Its interaction with plasminogen highlights its importance in the conversion pathway of plasminogen to plasmin which is essential in dissolving fibrin clots. Additionally Tetranectin’s contributions in the extracellular matrix further connect it with other proteins such as fibronectin and vitronectin facilitating cellular infrastructure and wound healing.

Researchers have linked alterations in Tetranectin levels with various conditions particularly cancer and osteoporosis. In cancer it associates with tumor growth and metastasis due to its role in tissue remodeling and plasminogen activation. In osteoporosis diminished levels of Tetranectin correlate with impaired bone density and integrative functions. Its interaction with plasminogen within these diseases illustrates not only its importance in fibrinolytic pathways but also its potential as a biomarker for pathological conditions.