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AB169918

Recombinant Human THAP11 protein

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(1 Publication)

Recombinant Human THAP11 protein is a Human Full Length protein, in the 1 to 314 aa range, expressed in Escherichia coli, with >90%, suitable for SDS-PAGE.

View Alternative Names

HRIHFB2206, THAP11, THAP domain-containing protein 11

Key facts

Purity

>90% SDS-PAGE

Expression system

Escherichia coli

Tags

Proprietary tag C-Terminus

Applications

SDS-PAGE

applications

Biologically active

No

Accession

Q96EK4

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 0.32% Tris HCl

storage-buffer

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Complementary Products

Primary Antibodies

AB154942

Anti-THAP11 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-THAP11 antibody (AB154942)

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Recombinant Human POLR1C protein

SDS-PAGE - Recombinant Human POLR1C protein (AB180317)

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Primary Antibodies

AB216347

Anti-SNAIL antibody [EPR21043]

20ul selling size|KO Validated|RabMAb|Recombinant

Western blot - Anti-SNAIL antibody [EPR21043] (AB216347)

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  • 1
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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Product details

Buffer contains NaCl, KCl, EDTA, arginine, DTT and Glycerol.
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Sequence info

[{"sequence":"GEFPGFTCCVPGCYNNSHRDKALHFYTFPKDAELRRLWLKNVSRAGVSGCFSTFQPTTGHRLCSVHFQGGRKTYTVRVPTIFPLRGVNERKVARRPAGAAAARRRQQQQQQQQQQQQQQQQQQQQQQQQQQQQQSSPSASTAQTAQLQPNLVSASAAVLLTLQATVDSSQAPGSVQPAPITPTGEDVKPIDLTVQVEFAAAEGAAAAAAASELQAATAGLEAAECPMGPQLVVVGEEGFPDTGSDHSYSLSSGTTEEELLRKLNEQRDILALMEVKMKEMKGSIRHLRLTEAKLREELREKDRLLAMAVIRKKHGMLEESGGGGSPGRRRRRRRRRRR","proteinLength":"Full Length","predictedMolecularWeight":"37.32 kDa","actualMolecularWeight":null,"aminoAcidEnd":314,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q96EK4","tags":[{"tag":"Proprietary","terminus":"C-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
-80°C
Appropriate long-term storage conditions
-80°C
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

THAP11 also known as THAP domain-containing protein 11 is a DNA-binding transcription factor with a mass of approximately 27 kDa. This protein is widely expressed in various tissues suggesting its role in fundamental cellular processes. It contains a THAP domain a zinc finger-like domain which allows it to bind to specific DNA sequences and regulate gene expression. The structure of THAP11 enables it to participate in transcriptional repression by interacting with other cofactors. Researchers have identified its presence in the nucleus indicating its function in the regulation of the genetic material.
Biological function summary

THAP11 plays a significant role in gene regulation and transcriptional control. It acts as part of a transcriptional repressor complex influencing cell proliferation and differentiation. THAP11 modulates the expression of genes that are important for maintaining cellular homeostasis and development. It interacts with other proteins and genetic elements to ensure proper cellular functioning. By controlling the expression of target genes THAP11 guides essential cellular processes impacting normal and pathological states.

Pathways

THAP11 is involved in multiple biological processes especially those related to stem cell maintenance and embryonic development. It is actively engaged in pathways like the Wnt signaling pathway where it regulates genes important for cell growth and division. THAP11 also interacts with proteins such as beta-catenin and TCF7L2 within these pathways modulating their activities to direct cell fate decisions. Its functional integration into these pathways highlights the importance of THAP11 in regulating developmental and cellular diversification processes.

THAP11 has associations with certain types of cancer such as colon cancer. Dysregulation of THAP11 expression or function can contribute to oncogenesis by disrupting normal patterns of cell growth and differentiation. It interacts with proteins like c-Myc in cancer pathways influencing tumor development and progression. Beyond cancer THAP11 mutations or malfunctions may also impact neurodevelopmental disorders where misregulation can affect normal neural differentiation and function. Understanding the role of THAP11 in these disease contexts is critical for developing therapeutic strategies.
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Specifications

Form

Liquid

Additional notes

ab169918 was expressed in E.coli as inclusion bodies then refolded using “temperature shift inclusion body refolding” technology and chromatographically purified.

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General info

Function

Transcription factor, which has both transcriptional activation and repression activities (PubMed : 31905202). Also modulates chromatin accessibility (PubMed : 38361031). In complex with HCFC1 and ZNF143, regulates the expression of several genes, including AP2S1, ESCO2, OPHN1, RBL1, UBXN8 and ZNF32 (PubMed : 26416877). May regulate the expression of genes that encode both cytoplasmic and mitochondrial ribosomal proteins (By similarity). Required for normal mitochondrial development and function. Regulates mitochondrial gene expression, including that of components of the electron transport chain (By similarity). Involved in the maintainance of pluripotency in early embryonic cells, possibly through its action on mitochondrial maturation which is required to meet high energy demands of these cells (By similarity). Required for early development of retina, preventing premature exit of retinal progenitor cells from the cell cycle. This effect may also be mediated by its action on mitochondria (By similarity). Through the regulation of MMACHC gene expression, controls cobalamin metabolism (PubMed : 28449119, PubMed : 31905202). Required for normal brain development and neural precursor differentiation (By similarity). Involved in cell growth (PubMed : 31905202).

Sequence similarities

Belongs to the THAP11 family.

Subcellular localisation

Nucleus

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Product protocols

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Target data

Transcription factor, which has both transcriptional activation and repression activities (PubMed : 31905202). Also modulates chromatin accessibility (PubMed : 38361031). In complex with HCFC1 and ZNF143, regulates the expression of several genes, including AP2S1, ESCO2, OPHN1, RBL1, UBXN8 and ZNF32 (PubMed : 26416877). May regulate the expression of genes that encode both cytoplasmic and mitochondrial ribosomal proteins (By similarity). Required for normal mitochondrial development and function. Regulates mitochondrial gene expression, including that of components of the electron transport chain (By similarity). Involved in the maintainance of pluripotency in early embryonic cells, possibly through its action on mitochondrial maturation which is required to meet high energy demands of these cells (By similarity). Required for early development of retina, preventing premature exit of retinal progenitor cells from the cell cycle. This effect may also be mediated by its action on mitochondria (By similarity). Through the regulation of MMACHC gene expression, controls cobalamin metabolism (PubMed : 28449119, PubMed : 31905202). Required for normal brain development and neural precursor differentiation (By similarity). Involved in cell growth (PubMed : 31905202).
See full target information THAP11
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Cell reports 42:112505 PubMed37182209

2023

Regulatory architecture of housekeeping genes is driven by promoter assemblies.

Applications

Unspecified application

Species

Unspecified reactive species

Marion Dejosez,Alessandra Dall'Agnese,Mahesh Ramamoorthy,Jesse Platt,Xing Yin,Megan Hogan,Ran Brosh,Abraham S Weintraub,Denes Hnisz,Brian J Abraham,Richard A Young,Thomas P Zwaka
View all publications
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Product promise

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