Recombinant Human THAP11 protein (denatured) is a Human Full Length protein, in the 1 to 314 aa range, expressed in Escherichia coli, with >80% purity and suitable for SDS-PAGE.
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Key facts
- Purity
- >80% SDS-PAGE
- Expression system
- Escherichia coli
- Tags
- His tag N-Terminus
- Applications
- SDS-PAGE
- Biologically active
- No
Amino acid sequence
M G S S H H H H H H S S G L V P R G S H M G S M P G F T C C V P G C Y N N S H R D K A L H F Y T F P K D A E L R R L W L K N V S R A G V S G C F S T F Q P T T G H R L C S V H F Q G G R K T Y T V R V P T I F P L R G V N E R K V A R R P A G A A A A R R R Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q S S P S A S T A Q T A Q L Q P N L V S A S A A V L L T L Q A T V D S S Q A P G S V Q P A P I T P T G E D V K P I D L T V Q V E F A A A E G A A A A A A A S E L Q A A T A G L E A A E C P M G P Q L V V V G E E G F P D T G S D H S Y S L S S G T T E E E L L R K L N E Q R D I L A L M E V K M K E M K G S I R H L R L T E A K L R E E L R E K D R L L A M A V I R K K H G M
Reactivity data
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
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Target data
Function
Transcriptional repressor that plays a central role for embryogenesis and the pluripotency of embryonic stem (ES) cells. Sequence-specific DNA-binding factor that represses gene expression in pluripotent ES cells by directly binding to key genetic loci and recruiting epigenetic modifiers (By similarity).
Alternative names
HRIHFB2206, THAP11, THAP domain-containing protein 11
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Recombinant Human THAP11 protein (denatured) is a Human Full Length protein, in the 1 to 314 aa range, expressed in Escherichia coli, with >80% purity and suitable for SDS-PAGE.
Key facts
- Purity
- >80% SDS-PAGE
- Expression system
- Escherichia coli
- Tags
- His tag N-Terminus
- Applications
- SDS-PAGE
- Biologically active
- No
- Accession
- Q96EK4-1
- Animal free
- No
- Species
- Human
- Concentration
- Storage buffer
pH: 8
Constituents: 10% Glycerol (glycerin, glycerine), 2.4% Urea, 0.32% Tris HCl
Sequence info
Amino acid sequence
- M G S S H H H H H H S S G L V P R G S H M G S M P G F T C C V P G C Y N N S H R D K A L H F Y T F P K D A E L R R L W L K N V S R A G V S G C F S T F Q P T T G H R L C S V H F Q G G R K T Y T V R V P T I F P L R G V N E R K V A R R P A G A A A A R R R Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q Q S S P S A S T A Q T A Q L Q P N L V S A S A A V L L T L Q A T V D S S Q A P G S V Q P A P I T P T G E D V K P I D L T V Q V E F A A A E G A A A A A A A S E L Q A A T A G L E A A E C P M G P Q L V V V G E E G F P D T G S D H S Y S L S S G T T E E E L L R K L N E Q R D I L A L M E V K M K E M K G S I R H L R L T E A K L R E E L R E K D R L L A M A V I R K K H G M
- Accession
- Q96EK4
- Protein length
- Full Length
- Predicted molecular weight
- 36.8 kDa
- Amino acids
- 1 to 314
- Nature
- Recombinant
- Tags
- His tag N-Terminus
Specifications
- Form
- Liquid
General info
- Function
Transcriptional repressor that plays a central role for embryogenesis and the pluripotency of embryonic stem (ES) cells. Sequence-specific DNA-binding factor that represses gene expression in pluripotent ES cells by directly binding to key genetic loci and recruiting epigenetic modifiers (By similarity).
- Sequence similarities
Belongs to the THAP11 family.
- Subcellular localisation
- Nucleus
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage duration
- 1-2 weeks
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
THAP11 also known as THAP domain-containing protein 11 is a DNA-binding transcription factor with a mass of approximately 27 kDa. This protein is widely expressed in various tissues suggesting its role in fundamental cellular processes. It contains a THAP domain a zinc finger-like domain which allows it to bind to specific DNA sequences and regulate gene expression. The structure of THAP11 enables it to participate in transcriptional repression by interacting with other cofactors. Researchers have identified its presence in the nucleus indicating its function in the regulation of the genetic material.
- Biological function summary
THAP11 plays a significant role in gene regulation and transcriptional control. It acts as part of a transcriptional repressor complex influencing cell proliferation and differentiation. THAP11 modulates the expression of genes that are important for maintaining cellular homeostasis and development. It interacts with other proteins and genetic elements to ensure proper cellular functioning. By controlling the expression of target genes THAP11 guides essential cellular processes impacting normal and pathological states.
- Pathways
THAP11 is involved in multiple biological processes especially those related to stem cell maintenance and embryonic development. It is actively engaged in pathways like the Wnt signaling pathway where it regulates genes important for cell growth and division. THAP11 also interacts with proteins such as beta-catenin and TCF7L2 within these pathways modulating their activities to direct cell fate decisions. Its functional integration into these pathways highlights the importance of THAP11 in regulating developmental and cellular diversification processes.
- Associated diseases and disorders
THAP11 has associations with certain types of cancer such as colon cancer. Dysregulation of THAP11 expression or function can contribute to oncogenesis by disrupting normal patterns of cell growth and differentiation. It interacts with proteins like c-Myc in cancer pathways influencing tumor development and progression. Beyond cancer THAP11 mutations or malfunctions may also impact neurodevelopmental disorders where misregulation can affect normal neural differentiation and function. Understanding the role of THAP11 in these disease contexts is critical for developing therapeutic strategies.
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1 product image
SDS-PAGE - Recombinant Human THAP11 protein (denatured) (ab180329)
15% SDS-PAGE analysis of 3μg ab180329.
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