Recombinant Human THAP3 protein (His tag N-Terminus)

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

THAP3 also known as Thanatos-associated protein domain-containing protein 3 is a nuclear protein with a molecular mass of approximately 34 kDa. It contains a THAP domain which is a conserved DNA-binding motif. THAP3 is expressed in various tissues including the heart and skeletal muscle indicating its importance in muscle function. The protein is involved in gene regulation interacting with DNA sequences and possibly influencing the transcriptional process.

Biological function summary

THAP3 modulates transcriptional activities by either activating or repressing the transcription of target genes. It associates with other protein complexes to exert its regulatory effects. In the nuclear environment THAP3 may play a role in maintaining chromatin structure therefore influencing gene accessibility for transcription machinery. These interactions position THAP3 as an important player in cellular processes that depend on precise gene regulation.

Pathways

THAP3 integrates into key signaling pathways including the apoptosis and transcriptional regulation pathways. It interacts with other transcription factors and regulators such as p53 in apoptosis regulation. By doing so THAP3 impacts the decision-making process of cells undergoing stress or damage. THAP3 also influences the PI3K/Akt signaling pathway associating with proteins like PTEN which are involved in controlling cell proliferation and survival.

THAP3 has implications in certain cardiac conditions and cancers. Mutations or dysregulation of THAP3 expression might contribute to cardiomyopathy due to its role in cardiac muscle function. THAP3 is also linked to tumorigenesis where it can influence cancer progression through its interaction with oncogenic pathways. Its association with p53 highlights its potential role in cancer biology as p53 mutations are widely implicated in various forms of cancer. Understanding this relationship could help in developing strategies for therapeutic interventions.