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AB181931

Recombinant Human THAP7 protein (denatured) (His tag N-Terminus)

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Recombinant Human THAP7 protein (denatured) (His tag N-Terminus) is a Human Full Length protein, in the 1 to 309 aa range, expressed in Escherichia coli, with >85%, suitable for SDS-PAGE.

View Alternative Names

THAP domain-containing protein 7, THAP7

1 Images
SDS-PAGE - Recombinant Human THAP7 protein (denatured) (His tag N-Terminus) (AB181931)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human THAP7 protein (denatured) (His tag N-Terminus) (AB181931)

15% SDS-PAGE analysis of 3 μg ab181931.

Key facts

Purity

>85% SDS-PAGE

Expression system

Escherichia coli

Tags

His tag N-Terminus

Applications

SDS-PAGE

applications

Biologically active

No

Accession

Q9BT49

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 10% Glycerol (glycerin, glycerine), 2.4% Urea, 0.32% Tris HCl

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MGSSHHHHHHSSGLVPRGSHMGSMPRHCSAAGCCTRDTRETRNRGISFHRLPKKDNPRRGLWLANCQRLDPSGQGLWDPASEYIYFCSKHFEEDCFELVGISGYHRLKEGAVPTIFESFSKLRRTTKTKGHSYPPGPAEVSRLRRCRKRCSEGRGPTTPFSPPPPADVTCFPVEEASAPATLPASPAGRLEPGLSSPFSDLLGPLGAQADEAGCSAQPSPERQPSPLEPRPVSPSAYMLRLPPPAGAYIQNEHSYQVGSALLWKRRAEAALDALDKAQRQLQACKRREQRLRLRLTKLQQERAREKRAQADARQTLKEHVQDFAMQLSSSMA","proteinLength":"Full Length","predictedMolecularWeight":"36.8 kDa","actualMolecularWeight":null,"aminoAcidEnd":309,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q9BT49","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

THAP7 also known as THAP domain-containing protein 7 functions mechanically as a transcriptional repressor. It is a part of the THAP domain protein family which has a conserved zinc finger DNA-binding domain. THAP7 has a molecular mass of approximately 66 kDa. It is expressed in several tissues with notable presence in the heart and testis. The presence of THAP7 in various tissues suggests it may have diverse roles in cellular processes.
Biological function summary

The actions of THAP7 involve regulating gene expression and cell cycle control. It interacts with other proteins to form transcriptional repressor complexes impacting gene silencing. These activities play roles in cell proliferation and differentiation. THAP7's involvement in these fundamental processes indicates its importance in maintaining cellular homeostasis.

Pathways

THAP7 participates in cell cycle regulation and transcription pathways. It has associations with the retinoblastoma pathway collaborating with proteins like E2F transcription factors to influence cell cycle progression. These interactions show that THAP7 contributes to the control of cellular division and proliferation impacting the transition through cell cycle phases.

THAP7 has links to cancer and cardiovascular diseases. Dysregulation of THAP7 expression or function may disrupt normal cell cycle control potentially leading to tumorigenesis. In cardiovascular diseases its expression in cardiac tissues associates with proteins involved in heart function. Understanding THAP7's roles could provide insights into therapeutic targets for these diseases.
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Specifications

Form

Liquid

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General info

Function

Chromatin-associated, histone tail-binding protein that represses transcription via recruitment of HDAC3 and nuclear hormone receptor corepressors.

Subcellular localisation

Nucleus

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Product protocols

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Target data

Chromatin-associated, histone tail-binding protein that represses transcription via recruitment of HDAC3 and nuclear hormone receptor corepressors.
See full target information THAP7
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