Recombinant Human ThB protein (Fc Chimera)

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

ThB also known as Thyroid Hormone Receptor Beta is a nuclear receptor with a molecular mass of approximately 55 kDa. ThB is mainly expressed in the liver kidney heart brain and skeletal muscle tissues. It functions as a transcription factor regulating gene expression by binding to thyroid hormone response elements in DNA upon thyroid hormone binding. As a nuclear receptor ThB plays an important role in controlling the transcription of target genes influenced by thyroid hormones.

Biological function summary

ThB modulates metabolism heart rate and body temperature by influencing genes related to these processes. It is not known to form part of any larger protein complexes but interacts directly with thyroid hormones such as thyroxine (T4) and triiodothyronine (T3). This interaction promotes gene expression changes mediating thyroid hormone effects on development differentiation and metabolic homeostasis.

Pathways

The target is central in the thyroid hormone signaling and regulation pathways. These pathways involve interactions with proteins such as retinoid X receptor (RXR) forming dimers that bind to specific DNA sequences allowing the regulation of gene expression. ThB is also involved in pathways affecting lipid metabolism and thermogenesis providing regulation through its interaction with thyroid hormones and associated proteins.

ThB has been linked to thyroid hormone resistance and certain metabolic syndromes. For thyroid hormone resistance mutations or malfunction in ThB disrupts normal thyroid hormone activity leading to altered feedback mechanisms and unintended metabolic outcomes. ThB’s role in metabolic syndromes involves interactions with proteins like peroxisome proliferator-activated receptors (PPAR) influencing lipid and glucose metabolism that when dysregulated can lead to disorders such as non-alcoholic fatty liver disease (NAFLD).