Recombinant Human THRSP protein

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

THRSP also known as Spot 14 (S14) is a protein involved in lipid metabolism. It is about 17 kDa in size and shows high expression levels in tissues involved in lipid synthesis such as the liver and adipose tissue. THRSP is a nuclear protein that takes part in the regulation of genes associated with lipogenesis although it does not have known enzymatic activity. Instead its role involves acting as a transcription cofactor influencing which genes get activated during fat production.

Biological function summary

THRSP regulates the expression of genes linked to fatty acid synthesis. It does not function as part of a larger complex but works independently to influence lipid metabolism. Research indicates THRSP interacts with other transcription factors to promote or suppress lipid metabolic processes. This influence on gene expression makes it essential for controlling lipid levels in cells and maintaining energy storage capacity.

Pathways

THRSP participates in the lipid biosynthesis pathway which is critical for storing and generating energy in cells. It is particularly important in the context of the SREBP (sterol regulatory element-binding proteins) pathway. SREBP are transcription factors that are key regulators of cholesterol and fatty acid synthesis. THRSP modulates the activity of this pathway working alongside proteins such as FASN (fatty acid synthase) to adjust the cellular environments' lipid composition.

THRSP has implications in metabolic diseases like obesity and certain types of cancer including breast cancer. Its role in lipid metabolism connects it to conditions where lipid balance and storage are disrupted. THRSP expression levels correlate with lipid accumulation in tumorous tissues indicating its involvement in cancer metabolism. Additionally there are connections to well-known cancer-related proteins like PPARγ which play roles in cell differentiation development and metabolism of fat.