JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB164147

Recombinant Human THSD4 protein

Be the first to review this product! Submit a review

|

(0 Publication)

Recombinant Human THSD4 protein is a Human Full Length protein, in the 1 to 490 aa range, expressed in Wheat germ, suitable for ELISA, WB.

View Alternative Names

UNQ9334/PRO34005, THSD4, Thrombospondin type-1 domain-containing protein 4, A disintegrin and metalloproteinase with thrombospondin motifs-like protein 6, ADAMTS-like protein 6, ADAMTSL-6

1 Images
SDS-PAGE - Recombinant Human THSD4 protein (AB164147)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human THSD4 protein (AB164147)

ab164147 on a 12.5% SDS-PAGE stained with Coomassie Blue.

Key facts

Expression system

Wheat germ

Tags

GST tag N-Terminus

Applications

ELISA, WB

applications

Biologically active

No

Accession

Q6ZMP0

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 0.79% Tris HCl, 0.31% Glutathione

storage-buffer

style
left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
style
left-column
style
left-column

Sequence info

[{"sequence":"MYKSNNYLALRSRSGRSIINGNWAIDRPGKYEGGGTMFTYKRPNEISSTAGESFLAEGPTNEILDVYMIHQQPNPGVHYEYVIMGTNAISPQVPPHRRPGEPFNGQMVTEGRSQEEGEQKGRNEEKEDLRGEAPEMFTSESAQTFPVRHPDRFSPHRPDNLVPPAPQPPRRSRDHNWKQLGTTECSTTCGKGSQYPIFRCVHRSTHEEAPESYCDSSMKPTPEEEPCNIFPCPAFWDIGEWSECSKTCGLGMQHRQVLCRQVYANRSLTVQPYRCQHLEKPETTSTCQLKICSEWQIRTDWTSCSVPCGVGQRTRDVKCVSNIGDVVDDEECNMKLRPNDIENCDMGPCAKSWFLTEWSERCSAECGAGVRTRSVVCMTNHVSSLPLEGCGNNRPAEATPCDNGPCTGKVEWFAGSWSQCSIECGSGTQQREVICVRKNADTFEVLDPSECSFLEKPPSQQSCHLKPCGAKWFSTEWSMSLQRAMLTRPS","proteinLength":"Full Length","predictedMolecularWeight":null,"actualMolecularWeight":null,"aminoAcidEnd":490,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Wheat germ","accessionNumber":"Q6ZMP0","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]
style
left-column

Properties and storage information

Shipped at conditions
Dry Ice
Appropriate short-term storage conditions
-80°C
Appropriate long-term storage conditions
-80°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
style
left-column

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

THSD4 also known as Thrombospondin Type 1 Domain-Containing Protein 4 or ADAMTSL6 is a protein involved in extracellular matrix interactions. It has a molecular mass of approximately 120 kDa. The protein is expressed in various tissues including connective tissues and the heart. THSD4 plays a role in forming and maintaining the structure of the extracellular matrix influencing tissue integrity and function.
Biological function summary

This protein interacts with components of the extracellular matrix contributing to its stability and elasticity. It participates in the formation of a larger protein complex cooperating with fibrillin and fibulin family proteins. By integrating into these complexes THSD4 contributes to the structural network that supports cellular functions and tissue resilience under mechanical stress.

Pathways

THSD4 influences extracellular matrix organization pathways and connective tissue development. It interacts with other ECM proteins such as fibrillin-1 and fibulin-2 contributing to the structural integrity of tissues. Through these interactions THSD4 ensures proper assembly and function within tissues impacting cell signaling and mechanical properties of the matrix.

THSD4 relates to connective tissue diseases and cardiovascular disorders. Mutations or dysfunctions in this protein can lead to conditions like Marfan syndrome and thoracic aortic aneurysms which compromise tissue elasticity and strength. The protein shares functional connections with fibrillin-1 and elastin both of which are significant in the maintenance of vascular and connective tissue integrity.
style
left-column

Specifications

Form

Liquid

style
left-column

General info

Function

Promotes FBN1 matrix assembly. Attenuates TGFB signaling, possibly by accelerating the sequestration of large latent complexes of TGFB or active TGFB by FBN1 microfibril assembly, thereby negatively regulating the expression of TGFB regulatory targets, such as POSTN.

style
left-column

Product protocols

style
left-column

Target data

Promotes FBN1 matrix assembly. Attenuates TGFB signaling, possibly by accelerating the sequestration of large latent complexes of TGFB or active TGFB by FBN1 microfibril assembly, thereby negatively regulating the expression of TGFB regulatory targets, such as POSTN.
See full target information THSD4
style
left-column
style
left-column
style
right-column

Complementary Products

Proteins & Peptides

AB164034

Recombinant Human GCC1 protein

SDS-PAGE - Recombinant Human GCC1 protein (AB164034)

  • 0
  • 0
Proteins & Peptides

AB163782

Recombinant Human VISTA protein

SDS-PAGE - Recombinant Human VISTA protein (AB163782)

  • 0
  • 0
Proteins & Peptides

AB164178

Recombinant Human Dock5 protein

SDS-PAGE - Recombinant Human Dock5 protein (AB164178)

  • 0
  • 0
Proteins & Peptides

AB316418

Recombinant Human GSDMD Protein Standard (His tag)

Sandwich ELISA - Recombinant Human GSDMD Protein Standard (His tag) (AB316418)

  • 0
  • 0

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com