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AB98233

Recombinant Human THTPA protein

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Recombinant Human THTPA protein is a Human Full Length protein, in the 1 to 230 aa range, expressed in Escherichia coli, with >90%, suitable for SDS-PAGE, Mass Spec.

View Alternative Names

Thiamine-triphosphatase, ThTPase, THTPA

1 Images
SDS-PAGE - Recombinant Human THTPA protein (AB98233)
  • SDS-PAGE

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SDS-PAGE - Recombinant Human THTPA protein (AB98233)

15% SDS-PAGE analysis of 3μg ab98233

Key facts

Purity

>90% SDS-PAGE

Expression system

Escherichia coli

Tags

His tag N-Terminus

Applications

SDS-PAGE, Mass Spec

applications

Biologically active

No

Accession

Q9BU02

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 10% Glycerol (glycerin, glycerine), 0.316% Tris HCl, 0.0154% (R*,R*)-1,4-Dimercaptobutan-2,3-diol

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "Mass Spec": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MGSSHHHHHHSSGLVPRGSHMAQGLIEVERKFLPGPGTEERLQELGGTLEYRVTFRDTYYDTPELSLMQADHWLRRREDSGWELKCPGAAGVLGPHTEYKELTAEPTIVAQLCKVLRADGLGAGDVAAVLGPLGLQEVASFVTKRSAWKLVLLGADEEEPQLRVDLDTADFGYAVGEVEALVHEEAEVPTALEKIHRLSSMLGVPAQETAPAKLIVYLQRFRPQDYQRLLEVNSSRERPQETEDPDHCLG","proteinLength":"Full Length","predictedMolecularWeight":"27.7 kDa","actualMolecularWeight":null,"aminoAcidEnd":230,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q9BU02","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The target THTPA also known as thiamine-triphosphatase is an enzyme involved in hydrolyzing thiamine triphosphate (ThTP) to thiamine diphosphate (ThDP). THTPA has a molecular mass of approximately 33 kDa. High expression levels are found in human brain and liver tissues suggesting a role in these organ systems. The enzyme's precise action helps control levels of ThTP a molecule with potential signaling functions in cells.
Biological function summary

THTPA converts thiamine triphosphate to thiamine diphosphate playing an important role in the management of cellular energy processes. THTPA functions independently without being a part of a larger multi-protein complex. The regulation of thiamine phosphate derivatives including ThDP is essential for proper metabolic functions and cellular energy homeostasis.

Pathways

The action of THTPA connects to the thiamine metabolism pathway. This pathway includes interactions with other enzymes like thiamine pyrophosphokinase which assists in the conversion of thiamine to ThDP. Another associated pathway is the biosynthesis of cofactors where thiamine derivatives serve as coenzymes in several enzymatic reactions influencing the activity of proteins such as pyruvate dehydrogenase.

Alterations in THTPA activity are linked to neurological conditions like Wernicke-Korsakoff syndrome and other thiamine deficiency disorders. This connection arises because thiamine is an essential nutrient important for neural function. Reduced THTPA activity may disturb thiamine phosphate levels paired with protein ThDP potentially leading to metabolic distress and contributing to disease development.
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Specifications

Form

Liquid

Additional notes

ab98233 was purified using conventional chromatography techniques.

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General info

Function

Hydrolase highly specific for thiamine triphosphate (ThTP).

Sequence similarities

Belongs to the ThTPase family.

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Product protocols

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Target data

Hydrolase highly specific for thiamine triphosphate (ThTP).
See full target information THTPA
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