Recombinant Human Thymosin beta 10 protein (GST tag N-Terminus)

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Thymosin beta 10 also known as TMSB10 is a small protein that plays a role in the dynamics of the cytoskeleton. It has a mass of approximately 5 kDa. TMSB10 is found in various tissues with high expression levels in the brain kidney and heart. Its function involves binding to actin monomers preventing polymerization and consequently regulating actin filament assembly in cells.

Biological function summary

TMSB10 significantly influences cell movement and proliferation. It serves as an actin-sequestering protein and is not generally part of a larger protein complex. TMSB10 promotes cell motility and plays an essential part in processes like wound healing and angiogenesis. Through these actions it helps in tissue regeneration and repair influencing the cell's structural organization and signaling.

Pathways

TMSB10 is involved in the actin cytoskeleton pathway and cellular signaling pathways that govern movement and shape changes in cells. Its interaction with actin places it in relation to actin-related protein (ARP) complexes such as Arp2/3 which facilitate actin filament branching. In addition TMSB10's regulation of actin dynamics links it to pathways involving proteins like cofilin which modulates actin filament turnover.

TMSB10 shows a connection to cancer and cardiovascular disorders. Elevated levels of TMSB10 have been associated with tumor progression due to its role in enhancing cell movement and metastasis. In cardiovascular disorders changes in TMSB10 expression can impact cardiac function due to its influence on actin dynamics. Proteins such as vascular endothelial growth factor (VEGF) interact with TMSB10 during pathological conditions further illustrating its role in disease mechanisms.