Recombinant Human Thyroid Hormone Receptor alpha 1 protein is a Human Full Length protein, expressed in Escherichia coli, with >95% purity and suitable for SDS-PAGE, FuncS.
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
Application FuncS | Reactivity Reacts | Dilution info - | Notes ab81885 has been applied in DNA and protein-protein interaction assays. 100 ng is sufficient for a protein-protein interaction assay. 1 unit equals 1 nanogram of purified protein. |
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Isoform Alpha-1. Nuclear hormone receptor that can act as a repressor or activator of transcription. High affinity receptor for thyroid hormones, including triiodothyronine and thyroxine. Isoform Alpha-2. Does not bind thyroid hormone and functions as a weak dominant negative inhibitor of thyroid hormone action.
EAR7, ERBA1, NR1A1, THRA1, THRA2, THRA, Thyroid hormone receptor alpha, Nuclear receptor subfamily 1 group A member 1, V-erbA-related protein 7, c-erbA-1, c-erbA-alpha, EAR-7
Recombinant Human Thyroid Hormone Receptor alpha 1 protein is a Human Full Length protein, expressed in Escherichia coli, with >95% purity and suitable for SDS-PAGE, FuncS.
pH: 7.9
Constituents: 20% Glycerol (glycerin, glycerine), 0.75% Potassium chloride, 0.316% Tris HCl, 0.0154% (R*,R*)-1,4-Dimercaptobutan-2,3-diol, 0.00584% EDTA
ab81885 is purified by a combination of affinity and gel filtration chromatography.
Isoform Alpha-1
Belongs to the nuclear hormone receptor family. NR1 subfamily.
The Thyroid Hormone Receptor alpha 1 also known as THRA or NR1A1 is a nuclear hormone receptor with a molecular mass of approximately 48 kDa. Mechanically it functions as a transcription factor that binds to specific DNA sequences to regulate gene expression. THRA typically forms heterodimers with the retinoid X receptor and binds to thyroid hormone response elements in the promoter region of target genes. It is expressed widely in the body with notable presence in tissues such as liver heart and brain.
The receptor influences multiple physiological processes. It plays an important role in regulating metabolism growth and development by controlling the expression of thyroid hormone-responsive genes. When thyroid hormones such as triiodothyronine (T3) bind to THRA they induce conformational changes that enable interaction with coactivators or corepressors facilitating transcriptional regulation. THRA does not usually act alone; it partners with various cofactors to form a functional complex that fine-tunes hormonal responses as needed.
THRA plays an integral role in the thyroid hormone signaling pathway and influences lipid metabolism. It regulates genes involved in energy utilization and lipid synthesis by interacting with other proteins like peroxisome proliferator-activated receptors (PPARs) and sterol regulatory element-binding proteins (SREBPs). These interactions help maintain homeostasis and adapt metabolic responses according to environmental cues and cellular needs.
Mutations or aberrations in THRA are linked to rare conditions such as resistance to thyroid hormone alpha (RTHα) and possibly certain metabolic disorders. RTHα is characterized by impaired growth and development among other symptoms. In these conditions altered THRA function disrupts normal thyroid hormone signaling which can affect related proteins such as thyroid hormone receptor beta (THRB). Understanding these associations helps in the development of targeted therapies that address specific dysfunctions in these pathways.
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