Recombinant Human Thyrotropin Releasing Hormone (TRH) protein is a Human Full Length protein, in the 1 to 242 aa range, expressed in Wheat germ and suitable for ELISA, WB.
Images
Key facts
- Expression system
- Wheat germ
- Tags
- GST tag N-Terminus
- Applications
- ELISA, WB
- Biologically active
- No
Amino acid sequence
M P G P W L L L A L A L T L N L T G V P G G R A Q P E A A Q Q E A V T A A E H P G L D D F L R Q V E R L L F L R E N I Q R L Q G D Q G E H S A S Q I F Q S D W L S K R Q H P G K R E E E E E E G V E E E E E E E G G A V G P H K R Q H P G R R E D E A S W S V D V T Q H K R Q H P G R R S P W L A Y A V P K R Q H P G R R L A D P K A Q R S W E E E E E E E E R E E D L M P E K R Q H P G K R A L G G P C G P Q G A Y G Q A G L L L G L L D D L S R S Q G A E E K R Q H P G R R A A W V R E P L E E
Reactivity data
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application ELISA | Reactivity Reacts | Dilution info - | Notes - |
Application WB | Reactivity Reacts | Dilution info - | Notes - |
Target data
Function
As a component of the hypothalamic-pituitary-thyroid axis, it controls the secretion of thyroid-stimulating hormone (TSH) and is involved in thyroid hormone synthesis regulation. It also operates as modulator of hair growth. It promotes hair-shaft elongation, prolongs the hair cycle growth phase (anagen) and antagonizes its termination (catagen) by TGFB2. It stimulates proliferation and inhibits apoptosis of hair matrix keratinocytes.
Additional Targets
Thyrotropin Releasing Hormone (TRH)
Alternative names
Pro-thyrotropin-releasing hormone, Pro-TRH, Prothyroliberin, TRH
Recommended products
Recombinant Human Thyrotropin Releasing Hormone (TRH) protein is a Human Full Length protein, in the 1 to 242 aa range, expressed in Wheat germ and suitable for ELISA, WB.
Key facts
- Expression system
- Wheat germ
- Tags
- GST tag N-Terminus
- Applications
- ELISA, WB
- Biologically active
- No
- Accession
- P20396-1
- Animal free
- No
- Species
- Human
- Concentration
- Storage buffer
pH: 8
Constituents: 0.79% Tris HCl, 0.31% Glutathione
Sequence info
Amino acid sequence
- M P G P W L L L A L A L T L N L T G V P G G R A Q P E A A Q Q E A V T A A E H P G L D D F L R Q V E R L L F L R E N I Q R L Q G D Q G E H S A S Q I F Q S D W L S K R Q H P G K R E E E E E E G V E E E E E E E G G A V G P H K R Q H P G R R E D E A S W S V D V T Q H K R Q H P G R R S P W L A Y A V P K R Q H P G R R L A D P K A Q R S W E E E E E E E E R E E D L M P E K R Q H P G K R A L G G P C G P Q G A Y G Q A G L L L G L L D D L S R S Q G A E E K R Q H P G R R A A W V R E P L E E
- Accession
- P20396
- Protein length
- Full Length
- Amino acids
- 1 to 242
- Nature
- Recombinant
- Tags
- GST tag N-Terminus
Specifications
- Form
- Liquid
General info
- Function
As a component of the hypothalamic-pituitary-thyroid axis, it controls the secretion of thyroid-stimulating hormone (TSH) and is involved in thyroid hormone synthesis regulation. It also operates as modulator of hair growth. It promotes hair-shaft elongation, prolongs the hair cycle growth phase (anagen) and antagonizes its termination (catagen) by TGFB2. It stimulates proliferation and inhibits apoptosis of hair matrix keratinocytes.
- Sequence similarities
Belongs to the TRH family.
Storage
- Shipped at conditions
- Dry Ice
- Appropriate short-term storage conditions
- -80°C
- Appropriate long-term storage conditions
- -80°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
Thyrotropin Releasing Hormone (TRH) also known as thyroliberin is a tripeptide hormone with a molecular mass of approximately 362.4 Da. This hormone mainly expresses in the hypothalamus of the brain. TRH plays an important role in the regulation of the thyroid axis by stimulating the secretion of thyroid-stimulating hormone (TSH) from the anterior pituitary gland. Additionally it influences the release of prolactin another pituitary hormone.
- Biological function summary
TRH serves important regulatory functions within the endocrine system. Notably TRH is an initiator in the hypothalamic-pituitary-thyroid (HPT) axis. It does not form part of a larger complex but acts as a standalone signaling molecule. This hormone facilitates communication between the central nervous system and the endocrine system influencing metabolic processes and affecting growth and development via its role in TSH and prolactin secretion.
- Pathways
TRH activates specific cell surface receptors linked to G-protein coupled signaling which increases the production of intracellular second messengers such as inositol triphosphate (IP3) and calcium ions. One significant pathway is the HPT axis which integrates TRH into a feedback cycle with thyroid hormones like thyroxine (T4) and triiodothyronine (T3). Proteins related to TRH within this signaling pathway include its target TSH which in turn regulates the biosynthesis of T3 and T4 in the thyroid gland.
- Associated diseases and disorders
TRH has been implicated in conditions such as hypothyroidism and major depressive disorder. In hypothyroidism insufficient production of TRH can result in decreased levels of TSH leading to reduced production of thyroid hormones and subsequent metabolic dysregulation. In major depressive disorder alterations in the HPT axis involving TRH may affect mood and cause other psychiatric symptoms. The function of TRH in these disorders highlights its interconnectedness with both TSH and the broader hormonal regulation within the body.
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1 product image
SDS-PAGE - Recombinant Human Thyrotropin Releasing Hormone (TRH) protein (ab159747)
ab159747 on a 12.5% SDS-PAGE stained with Coomassie Blue.
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