Recombinant Human TIGD5 protein (His-DHFR tag N-Terminus)

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

TIGD5 also known as tigger transposable element derived protein 5 is a protein involved in several cellular functions. It is encoded by the TIGD5 gene in humans and has a calculated molecular mass of approximately 71 kDa. TIGD5 shows expression in various tissues with higher levels in the testis and brain. Its mechanical role includes involvement in transcriptional regulation impacting gene expression through chromatin remodeling or interaction with other regulatory proteins.

Biological function summary

The protein plays a significant role in genomic stability and cellular development. TIGD5 is considered part of the protein families related to the tigger transposable element. It acts as a regulator in processes requiring precise gene expression and may also be involved in DNA repair due to its structural similarity with other protein coding genes. Its activity in these processes suggests an importance in maintaining cellular homeostasis and responding to environmental changes.

Pathways

TIGD5 interacts within networks that regulate cell cycle and DNA repair pathways. Notably it functions alongside proteins like p53 an important regulator of the cell cycle ensuring that cells properly respond to genomic stress. Additionally TIGD5 engagement in chromatin modification pathways supports its role in regulating access to genomic DNA during replication and transcription cycles.

TIGD5 variations have been associated with certain cancers and neurological conditions. Alterations in its expression or function may contribute to tumorigenesis through disrupted cell cycle control where defects in DNA repair mechanisms involving proteins like BRCA1 often play a part. Furthermore the abnormal function of TIGD5 in neural tissues may link to neurodegenerative diseases indicating a potential impact on neural health and recovery processes.