Recombinant Human TIM 1 protein (denatured)
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Recombinant Human TIM 1 protein (denatured) is a Human Fragment protein, in the 21 to 295 aa range, expressed in Escherichia coli, with >85%, suitable for SDS-PAGE.
View Alternative Names
CD365, KIM1, TIM1, TIMD1, HAVCR1, Hepatitis A virus cellular receptor 1, HAVcr-1, Kidney injury molecule 1, T-cell immunoglobulin and mucin domain-containing protein 1, T-cell immunoglobulin mucin receptor 1, T-cell membrane protein 1, KIM-1, TIMD-1, TIM, TIM-1
- SDS-PAGE
Supplier Data
SDS-PAGE - Recombinant Human TIM 1 protein (denatured) (AB203537)
15% SDS-PAGE analysis of ab203537 (3 μg).
Reactivity data
Sequence info
Properties and storage information
Shipped at conditions
Appropriate short-term storage duration
Appropriate short-term storage conditions
Appropriate long-term storage conditions
Aliquoting information
Storage information
Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
The TIM 1 protein functions as a receptor involved in T cell activity modulation and innate immune response regulation. It is known to bind phosphatidylserine on apoptotic cells which fosters communication between dying cells and phagocytes. TIM 1 does not typically exist as part of a larger complex but its interactions with other molecules is important for its role in the immune system. The protein’s activity influences cytokine production and this can affect inflammation processes.
Pathways
TIM 1 is involved in key immune response pathways like the signaling pathways of T cells and the broader adaptive immune response. This protein has been linked with the enhancement of Th2 cytokine production impacting allergic response signaling. It interacts with related proteins like TIM 3 and TIM 4 which together contribute to the fine-tuning of immune responses. Understanding TIM 1 within these pathways helps in grasping its regulatory potential in T-cell mediated immunity.
Specifications
Form
Liquid
General info
Function
Phosphatidylserine receptor that plays an important functional role in regulatory B-cells homeostasis including generation, expansion and suppressor functions (By similarity). As P-selectin/SELPLG ligand, plays a specialized role in activated but not naive T-cell trafficking during inflammatory responses (PubMed : 24703780). Controls thereby T-cell accumulation in the inflamed central nervous system (CNS) and the induction of autoimmune disease (PubMed : 24703780). Regulates also expression of various anti-inflammatory cytokines and co-inhibitory ligands including IL10 (By similarity). Acts as a regulator of T-cell proliferation (By similarity). May play a role in kidney injury and repair (PubMed : 17471468).. (Microbial infection) Acts as a receptor for Hepatitis A virus.. (Microbial infection) Acts as a receptor for Ebolavirus and Marburg virus by binding exposed phosphatidyl-serine at the surface of virion membrane (PubMed : 21536871). Serves as a dual receptor for Ebolavirus by also interacting with envelope glycoprotein GP (PubMed : 26487564).. (Microbial infection) Acts as a receptor for Dengue virus by binding exposed phosphatidyl-serine at the surface of virion membrane (PubMed : 23084921). TIM1 and Dengue virus are co-internalized during virus entry (PubMed : 29742433).. (Microbial infection) Acts as a receptor for Zika virus by binding to envelope protein E.. (Microbial infection) Plays a positive role in Chikungunya virus cell entry.
Sequence similarities
Belongs to the immunoglobulin superfamily. TIM family.
Post-translational modifications
Ubiquitinated at two lysine residues Lys-338 and Lys-346 on its cytoplasmic domain. Ubiquitination promotes receptor endocytosis and target receptors for lysosomal degradation and termination of receptor signaling.. (Microbial infection) Ubiquitination is required for Dengue virus endocytosis.
Target data
Complementary Products
![Western blot - Anti-TIM 1 antibody [3D9F5] (AB233720)](https://content.abcam.com/products/images/tim-1-antibody-3d9f5-ab233720--western-blot-img113125.jpg)
Product promise
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