Recombinant Human TIM 4 protein (Tagged)
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Recombinant Human TIM 4 protein (Tagged) is a Human Fragment protein, in the 25 to 315 aa range, expressed in HEK 293 cells, with >90%, suitable for WB, SDS-PAGE.
View Alternative Names
TIM4, TIMD4, T-cell immunoglobulin and mucin domain-containing protein 4, TIMD-4, T-cell immunoglobulin mucin receptor 4, T-cell membrane protein 4, TIM-4
- SDS-PAGE
Supplier Data
SDS-PAGE - Recombinant Human TIM 4 protein (Tagged) (AB271767)
SDS-PAGE analysis of 4 μg ab271767.
This protein runs at a higher MW by SDS-PAGE due to glycosylation.
- WB
Supplier Data
Western blot - Recombinant Human TIM 4 protein (Tagged) (AB271767)
All lanes:
Western blot - Recombinant Human TIM 4 protein (Tagged) (ab271767) at 4 µg
false
Reactivity data
Sequence info
Properties and storage information
Shipped at conditions
Appropriate short-term storage conditions
Appropriate long-term storage conditions
Storage information
Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
The function of TIM 4 extends to regulating immune homeostasis and tolerance. TIM 4 does not possess signaling motifs itself but often associates with other adaptor proteins to exert its biological effects. It acts independently or forms part of complexes that modulate cell signaling events influencing the outcome of immune responses. The protein plays important roles in maintaining the delicate balance of immune activation and suppression which is critical to preventing autoimmunity.
Pathways
TIM 4 interaction occurs in pathways like the phosphatidylserine-mediated phagocytosis pathway which involves clearance of apoptotic cells. TIM 4 engages with phosphatidylserine a process important to maintaining tissue homeostasis and preventing inflammation. It works alongside other proteins in similar pathways including TIM 3 where together they mediate distinct and overlapping cellular processes involved in immune regulation.
Specifications
Form
Liquid
General info
Function
Phosphatidylserine receptor that plays different role in immune response including phagocytosis of apoptotic cells and T-cell regulation. Controls T-cell activation in a bimodal fashion, decreasing the activation of naive T-cells by inducing cell cycle arrest, while increasing proliferation of activated T-cells by activating AKT1 and ERK1/2 phosphorylations and subsequent signaling pathways (By similarity). Also plays a role in efferocytosis which is the process by which apoptotic cells are removed by phagocytic cells (PubMed : 32703939, PubMed : 34067457). Mechanistically, promotes the engulfment of apoptotic cells or exogenous particles by securing them to phagocytes through direct binding to phosphatidylserine present on apoptotic cells, while other engulfment receptors such as MERTK efficiently recognize apoptotic cells and mediate their ingestion (PubMed : 32640697). Additionally, promotes autophagy process by suppressing NLRP3 inflammasome activity via activation of LKB1/PRKAA1 pathway in a phosphatidylserine-dependent mechanism (By similarity).. (Microbial infection) Plays a positive role in exosome-mediated trafficking of HIV-1 virus and its entry into immune cells.
Sequence similarities
Belongs to the immunoglobulin superfamily. TIM family.
Target data
Complementary Products
Product promise
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