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AB153274

Recombinant Human Tin2 protein (GST tag N-Terminus)

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Recombinant Human Tin2 protein (GST tag N-Terminus) is a Human Fragment protein, in the 256 to 354 aa range, expressed in Wheat germ, suitable for ELISA, WB.

View Alternative Names

TIN2, TINF2, TERF1-interacting nuclear factor 2, TRF1-interacting nuclear protein 2

1 Images
SDS-PAGE - Recombinant Human Tin2 protein (GST tag N-Terminus) (AB153274)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human Tin2 protein (GST tag N-Terminus) (AB153274)

ab153274 on a 12.5% SDS-PAGE stained with Coomassie Blue.

Key facts

Expression system

Wheat germ

Tags

GST tag N-Terminus

Applications

WB, ELISA

applications

Biologically active

No

Accession

Q9BSI4

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 0.79% Tris HCl, 0.31% Glutathione

storage-buffer

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Complementary Products

Primary Antibodies

AB197894

Anti-Tin2 antibody [EPR15319]

RabMAb|Recombinant

Western blot - Anti-Tin2 antibody [EPR15319] (AB197894)

  • 0
  • 0
Secondary Antibodies

AB150077

Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488)

Immunocytochemistry/ Immunofluorescence - Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (AB150077)

  • 5
  • 20
Proteins & Peptides

AB152335

Recombinant Human DKC1/Dyskerin protein (GST tag N-Terminus)

SDS-PAGE - Recombinant Human DKC1/Dyskerin protein (GST tag N-Terminus) (AB152335)

  • 0
  • 0
Proteins & Peptides

AB235678

Recombinant Human ENOX2/tNOX protein (Tagged)

SDS-PAGE - Recombinant Human ENOX2/tNOX protein (Tagged) (AB235678)

  • 0
  • 0
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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"RHFNLAPLGRRRVQSQWASTRGGHKERPTVMLFPFRNLGSPTQVISNPESKEEHAIYTADLAMGTRAPSNGKYKGPYQTLGGRALKENPVDLPATEQKE","proteinLength":"Fragment","predictedMolecularWeight":null,"actualMolecularWeight":null,"aminoAcidEnd":354,"aminoAcidStart":256,"nature":"Recombinant","expressionSystem":"Wheat germ","accessionNumber":"Q9BSI4","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Dry Ice
Appropriate short-term storage conditions
-80°C
Appropriate long-term storage conditions
-80°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

TIN2 also known as TERF1-interacting nuclear factor 2 is a pivotal protein involved in telomere maintenance. It has a molecular mass of approximately 50 kDa. This protein is expressed in the nucleus where it plays an integral role in structuring chromosome ends. TIN2 specifically associates with telomeric regions to regulate their length and integrity. It forms connections with other proteins to facilitate its function in telomers' structural configuration.
Biological function summary

TIN2 integrates into the shelterin complex a group of six proteins that protect telomeres from being recognized as DNA damage. It acts as a stabilizer within this complex and helps maintain telomere integrity. In doing so TIN2 modulates the actions of telomerase and other telomere-binding proteins to ensure proper chromosome end function. This responsibility makes it essential for preventing excessive telomere shortening which can lead to genomic instability.

Pathways

The involvement of TIN2 is significant in telomere length regulation and DNA damage response mechanisms. TIN2 operates within these pathways to manage telomerase activity and interaction with telomere ends. It collaborates with other shelterin proteins like TRF1 and TRF2 which also participate in maintaining telomere function. TIN2's role in these pathways highlights its contribution to chromosome end protection and preventive response against DNA damage.

TIN2 dysfunction is linked to conditions like dyskeratosis congenita and aplastic anemia. These disorders are marked by defective telomere maintenance leading to progressive bone marrow failure and other cellular deficiencies. Mutations in TIN2 can perturb the function of shelterin proteins including TRF1 contributing to the compromised telomere integrity seen in these diseases. Understanding TIN2's role offers insights into therapeutic targets for managing telomere-associated disorders.
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Specifications

Form

Liquid

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General info

Function

Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Plays a role in shelterin complex assembly. Isoform 1 may have additional role in tethering telomeres to the nuclear matrix.

Subcellular localisation

Nucleus

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Product protocols

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Target data

Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Plays a role in shelterin complex assembly. Isoform 1 may have additional role in tethering telomeres to the nuclear matrix.
See full target information TINF2
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Product promise

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