Recombinant Human TIP-1 protein

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

TIP-1 also known as Tax-interacting protein-1 or glutaminase-interacting protein (GIP) is a small protein with a mass of approximately 14.5 kDa. It functions mechanically by binding to PDZ domains found in a wide range of cellular proteins. TIP-1 expression occurs in various tissues with notable presence in the brain liver and kidney. Its ability to interact with PDZ domain-containing proteins plays an important role in cellular maintenance and signaling.

Biological function summary

TIP-1 functions as a regulator of cellular signaling pathways through its interaction with PDZ-domain proteins. It does not typically form part of a larger protein complex but rather acts as an independent modulator. TIP-1 influences cellular signaling by affecting the spatial arrangement of proteins in cells thereby impacting signal transduction mechanisms. This regulation can affect various biological processes including cell proliferation and apoptosis.

Pathways

TIP-1 plays a role in the Wnt signaling pathway where it interacts with proteins such as Dishevelled which is important for transducing Wnt signals. TIP-1 also has implications in the glutamate metabolic pathway by interacting with proteins like glutaminase. These pathways are essential for cellular growth processes and energy metabolism regulation showing the interconnectivity of TIP-1 with key cellular functions.

TIP-1 implicates itself in cancer and neurological disorders. Overexpression of TIP-1 has been associated with certain types of cancer where it may interact with proteins like β-catenin to impact cell proliferation and migration. In neurological disorders dysfunction in TIP-1's interactions within signaling pathways may contribute to diseases such as schizophrenia closely linked with disturbed glutamate signaling and TIP-1's PDZ domain interactions.