Sample Prep & Detection Kits
Conjugation kitsPurification kitsSample preparation kitsChromogen kitsIHC kitsChIP kitsAccessory Reagents & Controls
Accessory reagents & controlsBiochemicals
BiochemicalsProteins and Peptides
Proteins and peptidesOur latest ELISA kit: Human Tau (phospho T217) - Intracellular
Highly sensitive kit offering the most promising biomarkers for Alzheimer’s disease diagnostics. Learn about all product ranges with our product overviews.
Featured events
Make new connections at our global events.
Our programs
New Lab Program
Get a head start with our exclusive new lab discount. Enjoy 20% off and free shipping for three months.
New Biotech Program
Just starting out? Get 15% off and free shipping to your lab for six months.
Product promise
Peace of mind that all products perform as stated.
Product reviews
Leave reviews, get rewarded and help your community.
Trial program
Try untested species and applications to earn money off your next order.
Recombinant human Tissue Plasminogen Activator protein, Two Chain (Active) is a Human Full Length protein, in the 36 to 562 aa range, expressed in CHO, with >95% purity and suitable for SDS-PAGE, FuncS.
Alternative names=Tissue-type plasminogen activator, t-PA, t-plasminogen activator, tPA
>95% SDS-PAGE
CHO cells
Tag free
SDS-PAGE, FuncS
Yes
S Y Q V I C R D E K T Q M I Y Q Q H Q S W L R P V L R S N R V E Y C W C N S G R A Q C H S V P V K S C S E P R C F N G G T C Q Q A L Y F S D F V C Q C P E G F A G K C C E I D T R A T C Y E D Q G I S Y R G T W S T A E S G A E C T N W N S S A L A Q K P Y S G R R P D A I R L G L G N H N Y C R N P D R D S K P W C Y V F K A G K Y S S E F C S T P A C S E G N S D C Y F G N G S A Y R G T H S L T E S G A S C L P W N S M I L I G K V Y T A Q N P S A Q A L G L G K H N Y C R N P D G D A K P W C H V L K N R R L T W E Y C D V P S C S T C G L R Q Y S Q P Q F R I K G G L F A D I A S H P W Q A A I F A K H R R S P G E R F L C G G I L I S S C W I L S A A H C F Q E R F P P H H L T V I L G R T Y R V V P G E E E Q K F E V E K Y I V H K E F D D D T Y D N D I A L L Q L K S D S S R C A Q E S S V V R T V C L P P A D L Q L P D W T E C E L S G Y G K H E A L S P F Y S E R L K E A H V R L Y P S S R C T S Q H L L N R T V T D N M L C A G D T R S G G P Q A N L H D A C Q G D S G G P L V C L N D G R M T L V G I I S W G L G C G Q K D V P G V Y T K V T N Y L D W I R D N M R P
Application | Reactivity | Dilution info | Notes |
---|---|---|---|
Application SDS-PAGE | Reactivity Reacts | Dilution info - | Notes - |
Application FuncS | Reactivity Reacts | Dilution info - | Notes - |
Recombinant human Tissue Plasminogen Activator protein, Two Chain (Active) is a Human Full Length protein, in the 36 to 562 aa range, expressed in CHO, with >95% purity and suitable for SDS-PAGE, FuncS.
Alternative names=Tissue-type plasminogen activator, t-PA, t-plasminogen activator, tPA
>95% SDS-PAGE
CHO cells
Tag free
SDS-PAGE, FuncS
Yes
3,147,288 IU/mg (Relative to WHO International Standard for Human Recombinant Tissue Plasminogen Activator, NIBSC 98/714).
59.04 kDa
36 to 562
S Y Q V I C R D E K T Q M I Y Q Q H Q S W L R P V L R S N R V E Y C W C N S G R A Q C H S V P V K S C S E P R C F N G G T C Q Q A L Y F S D F V C Q C P E G F A G K C C E I D T R A T C Y E D Q G I S Y R G T W S T A E S G A E C T N W N S S A L A Q K P Y S G R R P D A I R L G L G N H N Y C R N P D R D S K P W C Y V F K A G K Y S S E F C S T P A C S E G N S D C Y F G N G S A Y R G T H S L T E S G A S C L P W N S M I L I G K V Y T A Q N P S A Q A L G L G K H N Y C R N P D G D A K P W C H V L K N R R L T W E Y C D V P S C S T C G L R Q Y S Q P Q F R I K G G L F A D I A S H P W Q A A I F A K H R R S P G E R F L C G G I L I S S C W I L S A A H C F Q E R F P P H H L T V I L G R T Y R V V P G E E E Q K F E V E K Y I V H K E F D D D T Y D N D I A L L Q L K S D S S R C A Q E S S V V R T V C L P P A D L Q L P D W T E C E L S G Y G K H E A L S P F Y S E R L K E A H V R L Y P S S R C T S Q H L L N R T V T D N M L C A G D T R S G G P Q A N L H D A C Q G D S G G P L V C L N D G R M T L V G I I S W G L G C G Q K D V P G V Y T K V T N Y L D W I R D N M R P
Full Length
No
Recombinant
Human
pH: 7.4
Constituents: 9.52% HEPES, 0.58% Sodium chloride
Liquid
Activated from single-chain form with immobilized plasmin. 100% complex formation with Human PAI1.
Converts the abundant, but inactive, zymogen plasminogen to plasmin by hydrolyzing a single Arg-Val bond in plasminogen. By controlling plasmin-mediated proteolysis, it plays an important role in tissue remodeling and degradation, in cell migration and many other physiopathological events. During oocyte activation, plays a role in cortical granule reaction in the zona reaction, which contributes to the block to polyspermy (By similarity).
Belongs to the peptidase S1 family.
The single chain, almost fully active enzyme, can be further processed into a two-chain fully active form by a cleavage after Arg-310 catalyzed by plasmin, tissue kallikrein or factor Xa.
Dry Ice
-80°C
Upon delivery aliquot
Avoid freeze / thaw cycle
This product is an active protein and may elicit a biological response in vivo, handle with caution.
Extinction Coefficient: 1.9
We are dedicated to supporting your work with high quality reagents and we are here for you every step of the way should you need us.
In the unlikely event of one of our products not working as expected, you are covered by our product promise.
Full details and terms and conditions can be found here:
Terms & Conditions.
Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.
For licensing inquiries, please contact partnerships@abcam.com