Recombinant Human TM2D3 protein

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

TM2D3 also known as BRI3BP is a transmembrane protein with a mass of approximately 37 kDa. It is expressed in various tissues including the brain heart and skeletal muscle. TM2D3 is embedded in cellular membranes and is thought to participate in molecular signaling. It interacts with other proteins through its transmembrane domains and contributes to signal transduction pathways.

Biological function summary

TM2D3 has roles in cellular communication and regulation. It is part of a protein complex involved in modulating cellular responses to external stimuli. TM2D3 may affect processes such as cell adhesion and migration by interacting with other membrane proteins influencing cellular dynamics. Researchers continue to determine exact biological mechanisms due to its significant presence in critical tissues.

Pathways

TM2D3 integrates into the Notch signaling pathway an important pathway for cell differentiation and proliferation. Its interaction with the Notch receptor and related components influences developmental processes. Additionally TM2D3 has connections with the MAPK signaling pathway where it may modulate responses to growth factors through interactions with proteins like MEK and ERK.

TM2D3 shows relevance to Alzheimer's disease and cancer. Studies suggest that TM2D3 may interact with APP (Amyloid precursor protein) related to Alzheimer's disease affecting amyloid plaque formation. In cancer alterations in TM2D3 expression have links with tumor progression possibly involving interactions with proteins like beta-catenin that can influence cell cycle regulation and metastasis. Ongoing research aims to clarify these associations and their implications for therapeutic strategies.