Recombinant Human TMED6 protein is a Human Full Length protein, in the 1 to 240 aa range, expressed in Wheat germ and suitable for ELISA, WB.
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- Nature communications 13:18152022RNA aptamers specific for transmembrane p24 trafficking protein 6 and Clusterin for the targeted delivery of imaging reagents and RNA therapeutics to human β cells.Applications:Unspecified applicationReactive species:Unspecified reactive speciesDimitri Van Simaeys,Adriana De La Fuente,Serena Zilio,Alessia Zoso,Victoria Kuznetsova,Oscar Alcazar,Peter Buchwald,Andrea Grilli,Jimmy Caroli,Silvio Bicciato,Paolo SerafiniPubMed 35383192
Key facts
- Expression system
- Wheat germ
- Tags
- GST tag N-Terminus
- Applications
- ELISA, WB
- Biologically active
- No
Amino acid sequence
M S P L L F G A G L V V L N L V T S A R S Q K T E P L S G S G D Q P L F R G A D R Y D F A I M I P P G G T E C F W Q F A H Q T G Y F Y F S C E V Q R T V G M S H D R H V A A T A H N P Q G F L I D T S Q G V R G Q I N F S T Q E T G F Y Q L C L S N Q H N H F G S V Q V Y L N F G V F Y E G P E T D H K Q K E R K Q L N D T L D A I E D G T Q K V Q N N I F H M W R Y Y N F A R M R K M A D F F L I Q S N Y N Y V N W W S T A Q S L V I I L S G I L Q L Y F L K R L F N V P T T T D T K K P R C
Reactivity data
| Application | Reactivity | Dilution info | Notes |
|---|---|---|---|
Application ELISA | Reactivity Reacts | Dilution info - | Notes - |
Application WB | Reactivity Reacts | Dilution info - | Notes - |
Target data
Alternative names
UNQ9146/PRO34237, TMED6, Transmembrane emp24 domain-containing protein 6, p24 family protein gamma-5, p24gamma5
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Recombinant Human TMED6 protein is a Human Full Length protein, in the 1 to 240 aa range, expressed in Wheat germ and suitable for ELISA, WB.
Key facts
- Expression system
- Wheat germ
- Tags
- GST tag N-Terminus
- Applications
- ELISA, WB
- Biologically active
- No
- Accession
- Q8WW62-1
- Animal free
- No
- Species
- Human
- Concentration
- Storage buffer
pH: 8
Constituents: 0.79% Tris HCl, 0.31% Glutathione
Sequence info
Amino acid sequence
- M S P L L F G A G L V V L N L V T S A R S Q K T E P L S G S G D Q P L F R G A D R Y D F A I M I P P G G T E C F W Q F A H Q T G Y F Y F S C E V Q R T V G M S H D R H V A A T A H N P Q G F L I D T S Q G V R G Q I N F S T Q E T G F Y Q L C L S N Q H N H F G S V Q V Y L N F G V F Y E G P E T D H K Q K E R K Q L N D T L D A I E D G T Q K V Q N N I F H M W R Y Y N F A R M R K M A D F F L I Q S N Y N Y V N W W S T A Q S L V I I L S G I L Q L Y F L K R L F N V P T T T D T K K P R C
- Accession
- Q8WW62
- Protein length
- Full Length
- Amino acids
- 1 to 240
- Nature
- Recombinant
- Tags
- GST tag N-Terminus
Specifications
- Form
- Liquid
General info
- Sequence similarities
Belongs to the EMP24/GP25L family.
Storage
- Shipped at conditions
- Dry Ice
- Appropriate short-term storage conditions
- -80°C
- Appropriate long-term storage conditions
- -80°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
TMED6 also known as Transmembrane Emp24 domain-containing protein 6 plays a role in cellular transport processes. It is a protein with a mass of about 29 kDa. TMED6 is involved in the trafficking of proteins between the endoplasmic reticulum and the Golgi apparatus. Expression of TMED6 is seen in various tissues including liver heart and brain highlighting its broad relevance in different physiological processes.
- Biological function summary
TMED6 participates in maintaining the integrity of the secretory pathway. It is part of the p24 family which contributes to the coat protein complex (COPI and COPII) vesicles responsible for shuttling proteins between cellular compartments. This role facilitates the correct sorting and modification of proteins ensuring they reach their intended cellular destinations.
- Pathways
TMED6 has an integral part in the secretory pathway and the vesicular transport process. It interacts with proteins like COPI and COPII which are important for vesicle budding from the endoplasmic reticulum. The secretory pathway is essential for protein processing and trafficking affecting how cells respond to various stimuli and maintain homeostasis.
- Associated diseases and disorders
Researchers have investigated TMED6's connection to conditions such as Alzheimer's disease and cardiovascular issues. Alzheimer's disease shows altered endoplasmic reticulum and Golgi function where TMED6's interactions with proteins such as gamma-secretase suggest a potential role in pathogenesis. Additionally cardiovascular disorders involve disruptions in protein transport pathways wherein TMED6's function in vesicular traffic could influence disease states.
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1 product image
SDS-PAGE - Recombinant Human TMED6 protein (ab165536)
ab165536 on a 12.5% SDS-PAGE stained with Coomassie Blue.
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