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AB165536

Recombinant Human TMED6 protein (GST tag N-Terminus)

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(1 Publication)

Recombinant Human TMED6 protein (GST tag N-Terminus) is a Human Full Length protein, in the 1 to 240 aa range, expressed in Wheat germ, suitable for ELISA, WB.

View Alternative Names

UNQ9146/PRO34237, TMED6, Transmembrane emp24 domain-containing protein 6, p24 family protein gamma-5, p24gamma5

1 Images
SDS-PAGE - Recombinant Human TMED6 protein (GST tag N-Terminus) (AB165536)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human TMED6 protein (GST tag N-Terminus) (AB165536)

ab165536 on a 12.5% SDS-PAGE stained with Coomassie Blue.

Key facts

Expression system

Wheat germ

Tags

GST tag N-Terminus

Applications

ELISA, WB

applications

Biologically active

No

Accession

Q8WW62

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 8 Constituents: 0.79% Tris HCl, 0.31% Glutathione

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MSPLLFGAGLVVLNLVTSARSQKTEPLSGSGDQPLFRGADRYDFAIMIPPGGTECFWQFAHQTGYFYFSCEVQRTVGMSHDRHVAATAHNPQGFLIDTSQGVRGQINFSTQETGFYQLCLSNQHNHFGSVQVYLNFGVFYEGPETDHKQKERKQLNDTLDAIEDGTQKVQNNIFHMWRYYNFARMRKMADFFLIQSNYNYVNWWSTAQSLVIILSGILQLYFLKRLFNVPTTTDTKKPRC","proteinLength":"Full Length","predictedMolecularWeight":null,"actualMolecularWeight":null,"aminoAcidEnd":240,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Wheat germ","accessionNumber":"Q8WW62","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Dry Ice
Appropriate short-term storage conditions
-80°C
Appropriate long-term storage conditions
-80°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

TMED6 also known as Transmembrane Emp24 domain-containing protein 6 plays a role in cellular transport processes. It is a protein with a mass of about 29 kDa. TMED6 is involved in the trafficking of proteins between the endoplasmic reticulum and the Golgi apparatus. Expression of TMED6 is seen in various tissues including liver heart and brain highlighting its broad relevance in different physiological processes.
Biological function summary

TMED6 participates in maintaining the integrity of the secretory pathway. It is part of the p24 family which contributes to the coat protein complex (COPI and COPII) vesicles responsible for shuttling proteins between cellular compartments. This role facilitates the correct sorting and modification of proteins ensuring they reach their intended cellular destinations.

Pathways

TMED6 has an integral part in the secretory pathway and the vesicular transport process. It interacts with proteins like COPI and COPII which are important for vesicle budding from the endoplasmic reticulum. The secretory pathway is essential for protein processing and trafficking affecting how cells respond to various stimuli and maintain homeostasis.

Researchers have investigated TMED6's connection to conditions such as Alzheimer's disease and cardiovascular issues. Alzheimer's disease shows altered endoplasmic reticulum and Golgi function where TMED6's interactions with proteins such as gamma-secretase suggest a potential role in pathogenesis. Additionally cardiovascular disorders involve disruptions in protein transport pathways wherein TMED6's function in vesicular traffic could influence disease states.
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Specifications

Form

Liquid

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General info

Sequence similarities

Belongs to the EMP24/GP25L family.

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Product protocols

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Target data

See full target information TMED6
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Nature communications 13:1815 PubMed35383192

2022

RNA aptamers specific for transmembrane p24 trafficking protein 6 and Clusterin for the targeted delivery of imaging reagents and RNA therapeutics to human β cells.

Applications

Unspecified application

Species

Unspecified reactive species

Dimitri Van Simaeys,Adriana De La Fuente,Serena Zilio,Alessia Zoso,Victoria Kuznetsova,Oscar Alcazar,Peter Buchwald,Andrea Grilli,Jimmy Caroli,Silvio Bicciato,Paolo Serafini
View all publications
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Product promise

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