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AB276633

Recombinant Human TMED9 protein (His tag)

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Recombinant Human TMED9 protein (His tag) is a Human Fragment protein, in the 1 to 202 aa range, expressed in HEK 293 cells, with >90%, < 1 EU/µg endotoxin level, suitable for SDS-PAGE.

View Alternative Names

GP25L2, TMED9, Transmembrane emp24 domain-containing protein 9, GMP25, Glycoprotein 25L2, p24 family protein alpha-2, p25, p24alpha2

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SDS-PAGE - Recombinant Human TMED9 protein (His tag) (AB276633)
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Supplier Data

SDS-PAGE - Recombinant Human TMED9 protein (His tag) (AB276633)

SDS-PAGE analysis of ab276633

Key facts

Purity

>90% SDS-PAGE

Endotoxin level

< 1 EU/µg

Expression system

HEK 293 cells

Tags

His tag C-Terminus

Applications

SDS-PAGE

applications

Biologically active

No

Accession

Q9BVK6

Animal free

No

Carrier free

No

Species

Human

Storage buffer

pH: 7.4 Constituents: 100% PBS

storage-buffer

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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Sequence info

[{"sequence":"MAVELGVLLVRPRPGTGLGRVMRTLLLVLWLATRGSALYFHIGETEKKCFIEEIPDETMVIGNYRTQLYDKQREEYQPATPGLGMFVEVKDPEDKVILARQYGSEGRFTFTSHTPGEHQICLHSNSTKFSLFAGGMLRVHLDIQVGEHANDYAEIAAKDKLSELQLRVRQLVEQVEQIQKEQNYQRWREERFRQTSESTNQR","proteinLength":"Fragment","predictedMolecularWeight":"20.8 kDa","actualMolecularWeight":null,"aminoAcidEnd":202,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"HEK 293 cells","accessionNumber":"Q9BVK6","tags":[{"tag":"His","terminus":"C-Terminus"}]}]
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Properties and storage information

Shipped at conditions
Ambient - Can Ship with Ice
Appropriate short-term storage conditions
-20°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
False
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

TMED9 also known as Transmembrane Emp24 Domain-Containing Protein 9 carries out important mechanical roles in cellular processes. TMED9 has a mass of about 25 kDa. It functions as a part of the p24 family of proteins known to help in the transportation of proteins between the endoplasmic reticulum and the Golgi apparatus. TMED9 contains domains that are typical for vesicular transport proteins. This protein expresses largely in various tissues including the liver and kidney where protein transport demands are high.
Biological function summary

The TMED9 protein engages in the regulation of protein transport and maturation within cells. It associates with other p24 proteins to form a complex that modulates trafficking of cargo molecules to their correct destinations. This complex plays a role in ensuring accurate membrane formation and lipid metabolism affecting cellular homeostasis. The interaction of TMED9 with other proteins especially within the p24 family is essential for its functional roles in the secretory pathway.

Pathways

TMED9 engages in the endoplasmic reticulum to Golgi transport pathway. This pathway is responsible for the precise delivery of proteins to the Golgi where they undergo further modification. Its interactions with other p24 family members like TMED2 support its role in vesicular transport. Additionally TMED9 might play roles in lipid metabolism intersecting with pathways where proteins such as apolipoproteins participate influencing cellular lipid balance and energy storage.

TMED9 involvement has been observed in conditions like liver diseases and certain types of cancer. TMED9 dysregulation impacts protein transport pathways contributing to cellular dysfunctions seen in liver cirrhosis. Also in certain cancers TMED9 interacts with proteins like TMED10 potentially affecting cell proliferation and migration. Understanding its role could help in developing therapeutic strategies targeting these pathways in disease contexts.
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Specifications

Form

Lyophilized

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General info

Function

Appears to be involved in vesicular protein trafficking, mainly in the early secretory pathway. In COPI vesicle-mediated retrograde transport involved in the coatomer recruitment to membranes of the early secretory pathway. Increases coatomer-dependent activity of ARFGAP2. Thought to play a crucial role in the specific retention of p24 complexes in cis-Golgi membranes; specifically contributes to the coupled localization of TMED2 and TMED10 in the cis-Golgi network. May be involved in organization of intracellular membranes, such as of the ER-Golgi intermediate compartment and the Golgi apparatus. Involved in ER localization of PTPN2 isoform PTPB.

Sequence similarities

Belongs to the EMP24/GP25L family.

Post-translational modifications

N-linked glycosylated containing high mannose.

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Product protocols

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Target data

Appears to be involved in vesicular protein trafficking, mainly in the early secretory pathway. In COPI vesicle-mediated retrograde transport involved in the coatomer recruitment to membranes of the early secretory pathway. Increases coatomer-dependent activity of ARFGAP2. Thought to play a crucial role in the specific retention of p24 complexes in cis-Golgi membranes; specifically contributes to the coupled localization of TMED2 and TMED10 in the cis-Golgi network. May be involved in organization of intracellular membranes, such as of the ER-Golgi intermediate compartment and the Golgi apparatus. Involved in ER localization of PTPN2 isoform PTPB.
See full target information TMED9
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