Recombinant Human TMEM116 protein

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

TMEM116 also known as Transmembrane Protein 116 is a protein with a molecular weight of approximately 23 kDa. It is a membrane-spanning protein typically found in tissues such as the liver lung and kidney. Its primary function involves maintaining cellular processes linked to membrane dynamics and intracellular signaling. Researchers have observed that TMEM116 may play a role in managing ion transport across cell membranes suggesting its involvement in cellular homeostasis.

Biological function summary

TMEM116 assists in regulating channels and transporters indicating its participation in essential cellular processes that affect ion gradient maintenance. TMEM116 does not function alone; it may associate with other transmembrane proteins to form a functional complex which helps regulate the passage of molecules across the cell membrane. This functional grouping suggests TMEM116 plays a considerable role in the broader context of cell signaling and metabolic regulation.

Pathways

TMEM116 associates with pathways like the sodium ion transport pathway and the cellular response to stress pathway. In the sodium ion transport pathway TMEM116 interacts with proteins such as the Na+/K+ ATPase pump which is essential for maintaining the electrolyte balance within cells. Meanwhile its role in stress response pathways hints at its contribution to cellular processes that protect cells from environmental changes or damage.

TMEM116 shows association with diseases like cystic fibrosis and certain types of cardiovascular diseases. In cystic fibrosis mutations or dysregulation of TMEM116 may disrupt normal ion transport further impacting respiratory function. Its connection to proteins like CFTR (Cystic Fibrosis Transmembrane Conductance Regulator) highlights its significance in this disease context. With cardiovascular diseases TMEM116's influence on ion channel function could contribute to abnormalities in heart muscle function showing its potential role in cardiac health.