Recombinant Human Tmem27 protein (Fc Chimera)
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Recombinant Human Tmem27 protein (Fc Chimera) is a Human Fragment protein, in the 1 to 141 aa range, expressed in HEK 293 cells, with >95%, < 1 EU/µg endotoxin level, suitable for SDS-PAGE.
View Alternative Names
TMEM27, UNQ679/PRO1312, CLTRN, Collectrin, Transmembrane protein 27
- SDS-PAGE
Supplier Data
SDS-PAGE - Recombinant Human Tmem27 protein (Fc Chimera) (AB276528)
SDS-PAGE analysis of ab276528
Reactivity data
Sequence info
Properties and storage information
Shipped at conditions
Appropriate short-term storage conditions
Appropriate long-term storage conditions
Aliquoting information
Storage information
Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
The involvement of Tmem27 extends to the regulation of amino acid transport and insulin exocytosis. It associates with the γ-aminobutyric acid type B receptor (GABBR) complex contributing to the modulation of nutrient uptake. Tmem27 influences the processing and trafficking of small neutral amino acids enhancing their absorption across epithelial barriers which is important for maintaining cellular homeostasis and metabolic activities.
Pathways
The function of Tmem27 is significant in the renin-angiotensin system and the insulin signaling pathway. In the renin-angiotensin system Tmem27 operates alongside the angiotensin-converting enzyme (ACE) to precisely regulate blood pressure homeostasis. It also acts within the insulin signaling pathway by modulating insulin secretion potentially working closely with glucose transporter type 4 (GLUT4) to ensure efficient glucose uptake by cells.
Specifications
Form
Lyophilized
General info
Function
Plays an important role in amino acid transport by acting as binding partner of amino acid transporters SLC6A18 and SLC6A19, regulating their trafficking on the cell surface and their amino acid transporter activity (By similarity). May also play a role in trafficking of amino acid transporters SLC3A1 and SLC7A9 to the renal cortical cell membrane (By similarity). Regulator of SNARE complex function (PubMed : 16330323). Stimulator of beta cell replication (PubMed : 16330323).
Sequence similarities
Belongs to the CLTRN family.
Post-translational modifications
Glycosylated. Glycosylation is required for plasma membrane localization and for its cleavage by BACE2.. Proteolytically processed in pancreatic beta cells by BACE2 leading to the generation and extracellular release of soluble CLTRN, and a corresponding cell-associated C-terminal fragment which is later cleaved by gamma-secretase. This shedding process inactivates CLTRN (By similarity). Three cleavage sites have been identified for BACE2, two clustered sites after Phe-116 and Leu-118 and a more membrane proximal site at Phe-125; the preferred BACE2 cleavage site seems to be between Phe-125 and Leu-126, Phe-116 and Leu-118 act as alternative sites (PubMed:21907142, PubMed:22628310).
Target data
Complementary Products
![Western blot - Anti-Tmem27 antibody [EPR17748] (AB200664)](https://content.abcam.com/products/images/tmem27-antibody-epr17748-ab200664--western-blot-img24911.jpg)
Product promise
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