Recombinant Human TMIGD1 protein (His tag)

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

TMIGD1 also known as Transmembrane and Immunoglobulin Domain Containing Protein 1 has a mass of approximately 34 kDa. This protein is localized to the plasma membrane and exhibits high expression in renal tissues including kidney epithelial cells. TMIGD1 may act as a cell surface receptor playing roles in cellular adhesion and signal transduction processes. Its structure involves an immunoglobulin-like domain suggesting a function in mediating interactions between cells or with the extracellular matrix.

Biological function summary

TMIGD1 contributes to maintaining cell integrity and supporting epithelial cell adherence. It seems to be involved in forming complexes with other cellular receptors or proteins that facilitate these cellular functions. This interaction is important for maintaining tissue structure and cellular communication within the renal system. Disruptions in TMIGD1 activity could lead to impaired cell adhesion and structural disarray.

Pathways

TMIGD1 shows involvement in pathways linked to cell adhesion and signal transduction. It collaborates with proteins like integrins and cadherins which are key players in the cellular adhesion machinery. Through these interactions TMIGD1 influences pathways that are important for cellular communication and adhesion directly impacting epithelial cell stability and kidney function.

TMIGD1 has shown associations with kidney-related conditions particularly renal carcinomas. Disruptions or mutations in TMIGD1 could interfere with normal kidney epithelial cell function contributing to the progression of renal cancer. Furthermore its relationship with integrins in this context points to its role in maintaining cellular adhesion which when compromised can influence cancer metastasis and progression.